Ute Hochgeschwender, M.D.

Photo of Ute Hochgeschwender

Phone: (919) 668-3705

221 Bryan Research Building
BOX 3209
Durham, NC 27710

Email: ute AT neuro DOT duke DOT edu

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Associate Research Professor; Director, Neurotransgenic Laboratory

Neurobiology, School of Medicine

DIBS Faculty

Research Description

My research interests are currently centered on combining optogenetics with bioluminescence, i.e. the activation of light-sensing opsins by biologically produced light through luciferases. Such bioluminescent opsins, luminopsins, might be used as tools for the in vivo manipulation and analysis of neuronal circuits.


Postdoctoral Fellow, The Scripps Research Institute, Molecular Neurobiology, 1986-1989

Postdoctoral Fellow, Max Planck Institute for Immunobiology, Cellular & Molecular Immunology, 1984-1986

M.D., Medical School, Free University of Berlin (Germany), 1983

M.A., Free University of Berlin (Germany), Philosophy, 1983

Recent Publications

Berglund K, Birkner E, Augustine GJ, Hochgeschwender U. Light-Emitting Channelrhodopsins for Combined Optogenetic and Chemical-Genetic Control of Neurons. PLoS ONE 8(3): e59759.doi:10.1371/journal.pone.0059759, 2013.

Costa JL, Forbes S, Brennan MB, Hochgeschwender U. Genetic modifications of mouse proopiomelanocortin peptide processing. Mol Cell Endocrinol 336, 14-22, 2011.

Zeyda T, Hochgeschwender U. Null mutant mouse models of somatostatin and cortistatin, and their receptors. Mol Cell Endocrinol 286, 18-25, 2008.

Research Areas

Research Topics

  • Genetically encoded neural effectors
  • Mouse models of neurological and psychiatric diseases
  • Genetic engineering of animal models