Accute And Chronic Effect Of Cannabidiol In A NeuroHIV Mouse Model

This seminar investigates the complex relationship between cannabidiol (CBD) and the endocannabinoid system within a specialized HIV-1 Tat mouse model. By comparing one-time acute exposure against a 12-week chronic regimen in aged mice, the study explores how treatment duration influences cognitive and behavioral outcomes. Results highlight a sophisticated restructuring of the endocannabinoid signaling landscape, where receptor expression and metabolic shifts are governed by intricate interactions between sex and genotype.