Ruth K. Broad Seminar
Duke Neurobiology welcomes Richard Tsien, PhD, Chair of New York University's Department of Neuroscience and Physiology and Director of NYU's Neuroscience Institute. Dr. Tsien will present "Homeostatically retuning synapses and spikes using "Hebbian" mechanisms." For connection info, email email@example.com. Partial abstract: There is no question that synaptic homeostasis exists and is important to keep circuits in tune in the face of activity deprivation (think stroke) or overactivity (think epilepsy). The prevailing view is that synaptic homeostasis is a slow, negative feedback system, quite distinct from LTP and other forms of Hebbian plasticity. This talk will present provocative data that challenges some of these ideas. We'll share unpublished evidence that synapses undergo a damped oscillatory response to homeostatic interventions that calls on spine depolarization, voltage-sensitive calcium entry and CaM kinases. The result is a faster, functionally powerful and potentially synapse-specific adjustment in strength.