Allen Wuming Song
Professor in Radiology
Overview
The research in our lab is concerned with advancing structural and functional MRI methodologies (e.g. fast and high-resolution imaging techniques) for human brain imaging. We also aim to improve our understanding of functional brain signals, including spatiotemporal characterizations of the blood oxygenation level dependent contrast and alternative contrast mechanisms that are more directly linked to the neuronal activities. Additional effort is invested in applying and validating the developed methods to study human functional neuroanatomy.
Selected Grants
A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation in patients with Subacute Thoracic Spinal Cord Injury to improve Pain and augment Rehabilitation awarded by National Institutes of Health (Collaborating Investigator). 2020 to 2025
Integrative modeling and dynamic prediction of Alzheimer's disease awarded by National Institutes of Health (Co Investigator). 2020 to 2025
Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024
Duke Resident Physician-Scientist Program in Radiation Oncology and Radiology awarded by National Institutes of Health (Preceptor). 2020 to 2024
Role of cannabis on HIV-related cognitive impairment: a brain connectomics study awarded by National Institutes of Health (Co Investigator). 2018 to 2023
Neuroimaging of Visual Attention in Aging awarded by National Institutes of Health (Co Investigator). 2011 to 2023
MRI data fusion to investigate effects of drug abuse on HIV neurological complications awarded by National Institutes of Health (Co Investigator). 2018 to 2023
NCANDA Research Project Site: Duke awarded by National Institutes of Health (Collaborator). 2012 to 2022
High Fidelity Diffusion MRI for Children with Cerebral Palsy in Stem Cell Therapy awarded by National Institutes of Health (Principal Investigator). 2012 to 2022
Next-generation high-resolution diffusion MRI resolving cortical columns and layers in vivo awarded by National Institutes of Health (Principal Investigator). 2019 to 2021
Pages
Zhang, Lijia, et al. “DTI Tract-Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients During Autologous Cord Blood Cell Therapy Using a Rotationally-Invariant Quantitative Measure.” J Magn Reson Imaging, vol. 53, no. 1, Jan. 2021, pp. 251–58. Pubmed, doi:10.1002/jmri.27286. Full Text
Simhal, Anish K., et al. “Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature.” Sci Rep, vol. 10, no. 1, July 2020, p. 10819. Pubmed, doi:10.1038/s41598-020-67474-9. Full Text
Dawson, Geraldine, et al. “A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.” J Pediatr, vol. 222, July 2020, pp. 164-173.e5. Pubmed, doi:10.1016/j.jpeds.2020.03.011. Full Text
Ghusayni, Ryan, et al. “Magnetic resonance imaging volumetric analysis in patients with Alternating hemiplegia of childhood: A pilot study.” Eur J Paediatr Neurol, vol. 26, May 2020, pp. 15–19. Pubmed, doi:10.1016/j.ejpn.2020.02.001. Full Text
Krystal, Andrew D., et al. “A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.” Nat Med, vol. 26, no. 5, May 2020, pp. 760–68. Pubmed, doi:10.1038/s41591-020-0806-7. Full Text
Truong, Trong-Kha, et al. “Toward direct MRI of neuro-electro-magnetic oscillations in the human brain.” Magn Reson Med, vol. 81, no. 6, June 2019, pp. 3462–75. Pubmed, doi:10.1002/mrm.27654. Full Text
Darnell, Dean, et al. “Integrated radio-frequency/wireless coil design for simultaneous MR image acquisition and wireless communication.” Magn Reson Med, vol. 81, no. 3, Mar. 2019, pp. 2176–83. Pubmed, doi:10.1002/mrm.27513. Full Text
Carpenter, Kimberly L. H., et al. “White Matter Tract Changes Associated with Clinical Improvement in an Open-Label Trial Assessing Autologous Umbilical Cord Blood for Treatment of Young Children with Autism.” Stem Cells Transl Med, vol. 8, no. 2, Feb. 2019, pp. 138–47. Pubmed, doi:10.1002/sctm.18-0251. Full Text
Krystal, Andrew D., et al. “The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.” Nat Rev Drug Discov, vol. 18, no. 1, Dec. 2018, pp. 82–84. Pubmed, doi:10.1038/nrd.2018.222. Full Text
Bruce, Iain P., et al. “Simultaneous and inherent correction of B0 and eddy-current induced distortions in high-resolution diffusion MRI using reversed polarity gradients and multiplexed sensitivity encoding (RPG-MUSE).” Neuroimage, vol. 183, Dec. 2018, pp. 985–93. Epmc, doi:10.1016/j.neuroimage.2018.09.055. Full Text
Pages
Helmer, K. G., et al. “Multi-site Study of Diffusion Metric Variability: Characterizing the Effects of Site, Vendor, Field Strength, and Echo Time using the Histogram Distance.” Proc Spie Int Soc Opt Eng, vol. 9788, 2016. Pubmed, doi:10.1117/12.2217449. Full Text
Helmer, K. G., et al. “Multi-site study of diffusion metric variability: effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses.” Proceedings of Spie the International Society for Optical Engineering, vol. 9788, 2016. Epmc, doi:10.1117/12.2217445. Full Text