Allison Elizabeth Ashley-Koch

Allison Elizabeth Ashley-Koch

Professor in Medicine

External Address: 
300 N Duke St., Durham, NC 27701
Internal Office Address: 
Duke Box 104775, Durham, NC 27701
Phone: 
919.684.1805

Overview

One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Education & Training

  • Ph.D., Emory University 1997

Selected Grants

Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health (Preceptor). 1975 to 2026

Genetic and Genomics Training Grant awarded by National Institutes of Health (Principal Investigator). 2020 to 2025

NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health (Mentor). 2009 to 2025

Epigenetic Age Acceleration and Psychoneurological Symptoms in Sickle Cell Disease awarded by National Institutes of Health (Co-Principal Investigator). 2022 to 2024

Identifying novel clinical, genetic and proteomic risk factors for sickle cell nephropathy. awarded by National Institutes of Health (Principal Investigator). 2021 to 2023

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders awarded by National Institutes of Health (Co Investigator). 2017 to 2022

RPE Exosomes in Age-related Macular Degeneration awarded by National Institutes of Health (Collaborator). 2021 to 2022

Eyes of Africa: The Genetics of Blindness awarded by University of Ibadan (Investigator). 2017 to 2022

Pages

Markunas, C. A., et al. “Genetics of the chiari I and II malformations.” The Chiari Malformations, 2020, pp. 289–97. Scopus, doi:10.1007/978-3-030-44862-2_23. Full Text

Markunas, C. A., et al. “Genetics of the Chiari i and II malformations.” The Chiari Malformations, vol. 9781461463696, 2013, pp. 93–101. Scopus, doi:10.1007/978-1-4614-6369-6_7. Full Text

Kimbrel, Nathan A., et al. “A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci.Mol Psychiatry, vol. 27, no. 4, Apr. 2022, pp. 2264–72. Pubmed, doi:10.1038/s41380-022-01472-3. Full Text

Liggett, L. Alexander, et al. “Clonal hematopoiesis in sickle cell disease.J Clin Invest, vol. 132, no. 4, Feb. 2022. Pubmed, doi:10.1172/JCI156060. Full Text

Zheng, Yuanchao, et al. “Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.Transl Psychiatry, vol. 11, no. 1, Dec. 2021, p. 637. Pubmed, doi:10.1038/s41398-021-01707-x. Full Text

Gamache, J., et al. “Parallel single-nucleus chromatin accessibility and transcriptomic profiling of human late-onset Alzheimer's disease brains.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association, vol. 17, Dec. 2021, p. e057261. Scopus, doi:10.1002/alz.057261. Full Text

Luo, Yang, et al. “Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.Nat Genet, vol. 53, no. 12, Dec. 2021, p. 1722. Pubmed, doi:10.1038/s41588-021-00979-9. Full Text

Luo, Yang, et al. “A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.Nat Genet, vol. 53, no. 10, Oct. 2021, pp. 1504–16. Pubmed, doi:10.1038/s41588-021-00935-7. Full Text

Cade, Brian E., et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.Genome Med, vol. 13, no. 1, Aug. 2021, p. 136. Pubmed, doi:10.1186/s13073-021-00917-8. Full Text

Barrera, Julio, et al. “Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains.Mol Neurodegener, vol. 16, no. 1, Aug. 2021, p. 58. Pubmed, doi:10.1186/s13024-021-00481-0. Full Text

Liang, Dan, et al. “Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.Nat Neurosci, vol. 24, no. 7, July 2021, pp. 941–53. Pubmed, doi:10.1038/s41593-021-00858-w. Full Text

Hu, Benxia, et al. “Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.Nat Commun, vol. 12, no. 1, June 2021, p. 3968. Pubmed, doi:10.1038/s41467-021-24243-0. Full Text

Pages

Wen, Fayuan, et al. “Genome Wide Association Analysis of Iron Overload in the Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Cohorts.” Blood, vol. 136, no. Supplement 1, American Society of Hematology, 2020, pp. 52–52. Crossref, doi:10.1182/blood-2020-142809. Full Text

Baker, C., et al. “IDENTIFICATION OF NOVEL CANDIDATE RISK GENES FOR MYELOMENINGOCELE WITHIN THE GLUCOSE HOMEOSTASIS AND FOLATE AND ONE CARBON METABOLISM NETWORKS.” Journal of Investigative Medicine, vol. 68, BMJ PUBLISHING GROUP, 2020, pp. A145–46. Wos, doi:10.1136/jim-2019-WMRC.336. Full Text

Kachroo, Priyadarshini, et al. “Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.Chest, vol. 156, no. 6, 2019, pp. 1068–79. Pubmed, doi:10.1016/j.chest.2019.08.2202. Full Text

Bundy, Joseph L., et al. “RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes.Plos One, vol. 14, no. 6, 2019, p. e0217042. Pubmed, doi:10.1371/journal.pone.0217042. Full Text

Gelineau-Van Waes, J., et al. “Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure.” Birth Defects Research, vol. 110, no. 9, WILEY, 2018, pp. 730–730.

Smith, Alicia, et al. “Meta-Analysis of DNA Methylation and PTSD in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup.” Neuropsychopharmacology, vol. 42, NATURE PUBLISHING GROUP, 2017, pp. S120–21.

Grotegut, Chad A., et al. “27: Single nucleotide polymorphisms in the oxytocin receptor and GRK6 are associated with oxytocin dosing requirements and labor outcomes.” American Journal of Obstetrics and Gynecology, vol. 216, no. 1, Elsevier BV, 2017, pp. S19–S19. Crossref, doi:10.1016/j.ajog.2016.11.918. Full Text

Jacob, Seethal A., et al. “Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 2491–2491. Crossref, doi:10.1182/blood.v128.22.2491.2491. Full Text

Xu, Julia Z., et al. “Factors Related to the Progression of Sickle Cell Disease Nephropathy.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 9–9. Crossref, doi:10.1182/blood.v128.22.9.9. Full Text

Anderson, Blair R., et al. “GWAS Meta-Analysis of Glomerular Filtration Rate in Three Cohorts of Sickle Cell Disease Patients and In Vivo Functional Analysis Reveals Potential Nephropathy Candidate Genes.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 269–269. Crossref, doi:10.1182/blood.v128.22.269.269. Full Text

Pages

Aung, Tin, et al. “Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.Nat Genet, vol. 47, no. 6, June 2015, p. 689. Pubmed, doi:10.1038/ng0615-689c. Full Text