Allison Elizabeth Ashley-Koch

Allison Elizabeth Ashley-Koch

Professor in Medicine

External Address: 
300 N Duke St., Durham, NC 27701
Internal Office Address: 
Duke Box 104775, Durham, NC 27701


One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Education & Training

  • Ph.D., Emory University 1997

Selected Grants

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health (Mentor). 2009 to 2025

IPA-Allison Ashley-Koch, MIRECC awarded by Durham Veterans Affairs Medical Center (Biostatistician Investigator). 2020 to 2022

IPA-Ashley-Koch, MVP awarded by Durham Veterans Affairs Medical Center (Biostatistician Investigator). 2020 to 2022

Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders awarded by National Institutes of Health (Co Investigator). 2017 to 2021

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

Transfusion Medicine and Hematology awarded by National Institutes of Health (Preceptor). 1975 to 2021

Sharing Comprehensive 'Omics in Sickle Cell Disease Through the NHLBI TOPMed Network awarded by Doris Duke Charitable Foundation, Inc. (Co Investigator). 2019 to 2020

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Transcriptomic, therapeutic and genetic investigations of sickle cell nephropathy awarded by National Institutes of Health (Principal Investigator). 2016 to 2020


Markunas, C. A., et al. “Genetics of the chiari I and II malformations.” The Chiari Malformations, 2020, pp. 289–97. Scopus, doi:10.1007/978-3-030-44862-2_23. Full Text

Markunas, C. A., et al. “Genetics of the Chiari i and II malformations.” The Chiari Malformations, vol. 9781461463696, 2013, pp. 93–101. Scopus, doi:10.1007/978-1-4614-6369-6_7. Full Text

Hillman, Paul, et al. “Identification of novel candidate risk genes for myelomeningocele within the glucose homeostasis/oxidative stress and folate/one-carbon metabolism networks.Molecular Genetics & Genomic Medicine, vol. 8, no. 11, Nov. 2020, p. e1495. Epmc, doi:10.1002/mgg3.1495. Full Text

Ilboudo, Yann, et al. “Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis.Blood Cells Mol Dis, vol. 86, Sept. 2020, p. 102504. Pubmed, doi:10.1016/j.bcmd.2020.102504. Full Text

Li, Xihao, et al. “Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.Nature Genetics, vol. 52, no. 9, Sept. 2020, pp. 969–83. Epmc, doi:10.1038/s41588-020-0676-4. Full Text

Morey, Rajendra A., et al. “Genetic predictors of hippocampal subfield volume in PTSD cases and trauma-exposed controls.Eur J Psychotraumatol, vol. 11, no. 1, July 2020, p. 1785994. Pubmed, doi:10.1080/20008198.2020.1785994. Full Text

Steffens, D. C., et al. “Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.Int Psychogeriatr, July 2020, pp. 1–9. Pubmed, doi:10.1017/S1041610220001143. Full Text

Worley, Gordon, et al. “Genetic variation in dopamine neurotransmission and motor development of infants born extremely-low-birthweight.Dev Med Child Neurol, vol. 62, no. 6, June 2020, pp. 750–57. Pubmed, doi:10.1111/dmcn.14383. Full Text

Logue, Mark W., et al. “An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.Clinical Epigenetics, vol. 12, no. 1, Mar. 2020, p. 46. Epmc, doi:10.1186/s13148-020-0820-0. Full Text

Grasby, Katrina L., et al. “The genetic architecture of the human cerebral cortex.Science (New York, N.Y.), vol. 367, no. 6484, Mar. 2020. Epmc, doi:10.1126/science.aay6690. Full Text Open Access Copy

Hebert, Luke, et al. “Burden of rare deleterious variants in WNT signaling genes among 511 myelomeningocele patients.Plos One, vol. 15, no. 9, 2020, p. e0239083. Pubmed, doi:10.1371/journal.pone.0239083. Full Text

Nouraie, Mehdi, et al. “Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts.Plos One, vol. 15, no. 8, 2020, p. e0237543. Pubmed, doi:10.1371/journal.pone.0237543. Full Text


Kachroo, Priyadarshini, et al. “Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.Chest, vol. 156, no. 6, 2019, pp. 1068–79. Pubmed, doi:10.1016/j.chest.2019.08.2202. Full Text

Bundy, Joseph L., et al. “RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes.Plos One, vol. 14, no. 6, 2019, p. e0217042. Pubmed, doi:10.1371/journal.pone.0217042. Full Text

Gelineau-Van Waes, J., et al. “Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure.” Birth Defects Research, vol. 110, no. 9, WILEY, 2018, pp. 730–730.

Smith, Alicia, et al. “Meta-Analysis of DNA Methylation and PTSD in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup.” Neuropsychopharmacology, vol. 42, NATURE PUBLISHING GROUP, 2017, pp. S120–21.

Grotegut, Chad A., et al. “Single nucleotide polymorphisms in the oxytocin receptor and GRK6 are associated with oxytocin dosing requirements and labor outcomes.” American Journal of Obstetrics and Gynecology, vol. 216, no. 1, MOSBY-ELSEVIER, 2017, pp. S19–S19.

Jacob, Seethal A., et al. “Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 2491–2491. Crossref, doi:10.1182/blood.v128.22.2491.2491. Full Text

Xu, Julia Z., et al. “Factors Related to the Progression of Sickle Cell Disease Nephropathy.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 9–9. Crossref, doi:10.1182/blood.v128.22.9.9. Full Text

Anderson, Blair R., et al. “GWAS Meta-Analysis of Glomerular Filtration Rate in Three Cohorts of Sickle Cell Disease Patients and In Vivo Functional Analysis Reveals Potential Nephropathy Candidate Genes.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 269–269. Crossref, doi:10.1182/blood.v128.22.269.269. Full Text

Smith, Alicia, et al. “Epigenome-Wide Association of PTSD from Heterogeneous Cohorts with a Common Multi-Site Analysis Pipeline.” Biological Psychiatry, vol. 79, no. 9, ELSEVIER SCIENCE INC, 2016, pp. 164S-165S.

Morey, Rajendra A., et al. “Genome-Wide Association of Neuroimaging Phenotypes in PTSD at Multiple Sites.” Biological Psychiatry, vol. 79, no. 9, ELSEVIER SCIENCE INC, 2016, pp. 165S-165S.


Aung, Tin, et al. “Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.Nat Genet, vol. 47, no. 6, June 2015, p. 689. Pubmed, doi:10.1038/ng0615-689c. Full Text