Allison Elizabeth Ashley-Koch
Professor in Medicine
Overview
Selected Grants
Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health (Preceptor). 1975 to 2026
Genetic and Genomics Training Grant awarded by National Institutes of Health (Principal Investigator). 2020 to 2025
NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health (Mentor). 2009 to 2025
Untangling the diversity in the genetic architecture of late-onset Alzheimer's disease using single cell multi-omics awarded by National Institutes of Health (Co Investigator). 2022 to 2025
Epigenetic Age Acceleration and Psychoneurological Symptoms in Sickle Cell Disease awarded by National Institutes of Health (Co-Principal Investigator). 2022 to 2024
Identifying novel clinical, genetic and proteomic risk factors for sickle cell nephropathy. awarded by National Institutes of Health (Principal Investigator). 2021 to 2023
A Phase II trial of topical sodium nitrite in patients with sickle cell disease and leg ulcers Cost Reimbursable awarded by Food and Drug Administration (Collaborator). 2017 to 2022
Trauma and Genomics Modulate Brain Structure across Common Psychiatric Disorders awarded by National Institutes of Health (Co Investigator). 2017 to 2022
RPE Exosomes in Age-related Macular Degeneration awarded by National Institutes of Health (Collaborator). 2021 to 2022
Eyes of Africa: The Genetics of Blindness awarded by University of Ibadan (Investigator). 2017 to 2022
Pages
Markunas, C. A., et al. “Genetics of the chiari I and II malformations.” The Chiari Malformations, 2020, pp. 289–97. Scopus, doi:10.1007/978-3-030-44862-2_23. Full Text
Markunas, C. A., et al. “Genetics of the Chiari i and II malformations.” The Chiari Malformations, vol. 9781461463696, 2013, pp. 93–101. Scopus, doi:10.1007/978-1-4614-6369-6_7. Full Text
Kimbrel, Nathan A., et al. “A genome-wide association study of suicide attempts in the million veterans program identifies evidence of pan-ancestry and ancestry-specific risk loci.” Mol Psychiatry, vol. 27, no. 4, Apr. 2022, pp. 2264–72. Pubmed, doi:10.1038/s41380-022-01472-3. Full Text
Liggett, L. Alexander, et al. “Clonal hematopoiesis in sickle cell disease.” J Clin Invest, vol. 132, no. 4, Feb. 2022. Pubmed, doi:10.1172/JCI156060. Full Text
Zheng, Yuanchao, et al. “Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.” Transl Psychiatry, vol. 11, no. 1, Dec. 2021, p. 637. Pubmed, doi:10.1038/s41398-021-01707-x. Full Text
Gamache, J., et al. “Parallel single-nucleus chromatin accessibility and transcriptomic profiling of human late-onset Alzheimer's disease brains.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association, vol. 17, Dec. 2021, p. e057261. Scopus, doi:10.1002/alz.057261. Full Text
Luo, Yang, et al. “Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet, vol. 53, no. 12, Dec. 2021, p. 1722. Pubmed, doi:10.1038/s41588-021-00979-9. Full Text
Luo, Yang, et al. “A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.” Nat Genet, vol. 53, no. 10, Oct. 2021, pp. 1504–16. Pubmed, doi:10.1038/s41588-021-00935-7. Full Text
Cade, Brian E., et al. “Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.” Genome Med, vol. 13, no. 1, Aug. 2021, p. 136. Pubmed, doi:10.1186/s13073-021-00917-8. Full Text
Barrera, Julio, et al. “Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains.” Mol Neurodegener, vol. 16, no. 1, Aug. 2021, p. 58. Pubmed, doi:10.1186/s13024-021-00481-0. Full Text
Liang, Dan, et al. “Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation.” Nat Neurosci, vol. 24, no. 7, July 2021, pp. 941–53. Pubmed, doi:10.1038/s41593-021-00858-w. Full Text
Hu, Benxia, et al. “Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders.” Nat Commun, vol. 12, no. 1, June 2021, p. 3968. Pubmed, doi:10.1038/s41467-021-24243-0. Full Text
Pages
Wen, Fayuan, et al. “Genome Wide Association Analysis of Iron Overload in the Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Cohorts.” Blood, vol. 136, no. Supplement 1, American Society of Hematology, 2020, pp. 52–52. Crossref, doi:10.1182/blood-2020-142809. Full Text
Baker, C., et al. “IDENTIFICATION OF NOVEL CANDIDATE RISK GENES FOR MYELOMENINGOCELE WITHIN THE GLUCOSE HOMEOSTASIS AND FOLATE AND ONE CARBON METABOLISM NETWORKS.” Journal of Investigative Medicine, vol. 68, BMJ PUBLISHING GROUP, 2020, pp. A145–46. Wos, doi:10.1136/jim-2019-WMRC.336. Full Text
Kachroo, Priyadarshini, et al. “Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.” Chest, vol. 156, no. 6, 2019, pp. 1068–79. Pubmed, doi:10.1016/j.chest.2019.08.2202. Full Text
Bundy, Joseph L., et al. “RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes.” Plos One, vol. 14, no. 6, 2019, p. e0217042. Pubmed, doi:10.1371/journal.pone.0217042. Full Text
Gelineau-Van Waes, J., et al. “Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure.” Birth Defects Research, vol. 110, no. 9, WILEY, 2018, pp. 730–730.
Smith, Alicia, et al. “Meta-Analysis of DNA Methylation and PTSD in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup.” Neuropsychopharmacology, vol. 42, NATURE PUBLISHING GROUP, 2017, pp. S120–21.
Grotegut, Chad A., et al. “27: Single nucleotide polymorphisms in the oxytocin receptor and GRK6 are associated with oxytocin dosing requirements and labor outcomes.” American Journal of Obstetrics and Gynecology, vol. 216, no. 1, Elsevier BV, 2017, pp. S19–S19. Crossref, doi:10.1016/j.ajog.2016.11.918. Full Text
Jacob, Seethal A., et al. “Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 2491–2491. Crossref, doi:10.1182/blood.v128.22.2491.2491. Full Text
Xu, Julia Z., et al. “Factors Related to the Progression of Sickle Cell Disease Nephropathy.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 9–9. Crossref, doi:10.1182/blood.v128.22.9.9. Full Text
Anderson, Blair R., et al. “GWAS Meta-Analysis of Glomerular Filtration Rate in Three Cohorts of Sickle Cell Disease Patients and In Vivo Functional Analysis Reveals Potential Nephropathy Candidate Genes.” Blood, vol. 128, no. 22, American Society of Hematology, 2016, pp. 269–269. Crossref, doi:10.1182/blood.v128.22.269.269. Full Text
Pages
Aung, Tin, et al. “Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.” Nat Genet, vol. 47, no. 6, June 2015, p. 689. Pubmed, doi:10.1038/ng0615-689c. Full Text