Amir H. Rezvani
Professor in Psychiatry and Behavioral Sciences
Alcoholism: I work with "alcoholic" rats with genetic predisposition!" We use selectively-bred alcohol preferring rats as an animal model of human alcoholism for developing better pharmacological treatments for alcoholism. Recently, we are working on several novel promissing "anti-craving" compounds for the treatment of alcoholism. We are also studing the interaction bewteen alcohol drinking and nicotine intake.
Nicotine Addiction: We have been studying age and sex differences in i.v. nicotine self-administration in rats. We have found that pattern of drug intake is both age- and sex-dependent. Our lab is also exploring different neuronal targets for developing better pharmacologic treatment for nicotine addiction.
Sustained Attention: Another aspect of our research is studying the role of the neuronal nicotinic and other neuronal systems in sustained attention using a rodent model. We have shown, nicotine (not smoking!) and nicotinic compounds improve attention in rats. A majority of people with schizophrenia smoke and they smoke heavily. Thus, it is important to understand the interaction of antipsychotic medications and nicotine in sustained attention. This has been another aspect of our research with interesting results. Presently, we are testing novel nicotinic compounds for improving pharmacologically-impaired sustained attention.
Teaching: I love to teach and interact with students. Since arriving at Duke in 1999, I have been team-teaching the popular alcohol course (Psych 206-01R; Alcohol: Brain, Society and Individual). I also enjoy mentoring undergrad students who are interested in science and enjoy working in the lab with cute little creatures!.
Community: I am a member of the Board of Directors of Triangle Residential Options for Substance Abusers (TROSA), a self-supported therapeutic community in Durham. I also give seminars and workshops on addiction around the country.
Reinforcing effect of nicotine alone vs. nicotine plus other chemicals in tobacco awarded by Rose Research Center, LLC (Co Investigator). 2019 to 2020
Paternal Transgenerational Epigenetic Legacy from Use of Cannabis awarded by John Templeton Foundation (Co Investigator). 2017 to 2020
Study of Novel Treatment to Prevent Acquisition of Opiate Self-Administration in Rats awarded by Amygdala Neurosciences Inc. (Principal Investigator). 2017 to 2019
Targeted tobacco regulatory science: Nicotine dose effects in animal models of smoking initiation in vulnerable adolescent subpopulations awarded by Minneapolis Medical Research Foundation (Principal Investigator). 2016 to 2019
Nicotinic Receptor Desensitization to Reduce Drug Self-Administration: Project 2 awarded by Georgetown University (Co Investigator). 2010 to 2015
Adolescence: A Sensitive Period for Nicotine Addiction awarded by National Institutes of Health (Co Investigator). 2004 to 2010
Nicotinic-Antipsychotic Drug Interactions and Cognition awarded by National Institutes of Health (Co Investigator). 2001 to 2006
Rezvani, A. H., et al. “Oral 18-Methoxycoronaridine (18-MC) Decreases Nicotine Self-Administration in Rats.” Neuroscience of Nicotine: Mechanisms and Treatment, 2019, pp. 493–97. Scopus, doi:10.1016/B978-0-12-813035-3.00059-9. Full Text
Rezvani, A. H. “Involvement of the NMDA system in learning and memory.” Animal Models of Cognitive Impairment, 2006, pp. 37–48.
Levin, E. D., and A. H. Rezvani. “Nicotinic involvement in cognitive function of rats.” Nicotinic Receptors in the Nervous System, 2001, pp. 167–78.
Blair, Graham, et al. “Dextromethorphan and bupropion reduces high level remifentanil self-administration in rats.” Pharmacol Biochem Behav, vol. 193, June 2020, p. 172919. Pubmed, doi:10.1016/j.pbb.2020.172919. Full Text Open Access Copy
Levin, Edward D., et al. “Amitifadine, a triple reuptake inhibitor, reduces self-administration of the opiate remifentanil in rats.” Psychopharmacology (Berl), vol. 237, no. 6, June 2020, pp. 1681–89. Pubmed, doi:10.1007/s00213-020-05489-w. Full Text
Levin, Edward D., et al. “Prolonging the Reduction of Nicotine Self-Administration in Rats by Coadministering Chronic Nicotine With Amitifadine, a Triple Monoamine Reuptake Inhibitor With CYP2B6 Inhibitory Actions.” Nicotine Tob Res, vol. 22, no. 2, Feb. 2020, pp. 232–37. Pubmed, doi:10.1093/ntr/ntz054. Full Text Open Access Copy
Willette, Blair K. A., et al. “Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats.” Pharmacol Biochem Behav, vol. 186, Nov. 2019, p. 172766. Pubmed, doi:10.1016/j.pbb.2019.172766. Full Text
Levin, Edward D., et al. “Chronic memantine decreases nicotine self-administration in rats.” Eur J Pharmacol, vol. 861, Oct. 2019, p. 172592. Pubmed, doi:10.1016/j.ejphar.2019.172592. Full Text
Levin, Edward D., et al. “Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.” Neurotoxicol Teratol, vol. 74, July 2019, p. 106806. Pubmed, doi:10.1016/j.ntt.2019.04.003. Full Text
Hawkey, Andrew B., et al. “Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.” Neurotoxicol Teratol, vol. 74, July 2019, p. 106808. Pubmed, doi:10.1016/j.ntt.2019.05.001. Full Text Open Access Copy
Rezvani, Amir H., et al. “Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.” Pharmacol Biochem Behav, vol. 179, Apr. 2019, pp. 109–12. Pubmed, doi:10.1016/j.pbb.2019.02.007. Full Text
Levin, Edward D., et al. “α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.” Eur J Pharmacol, vol. 845, Feb. 2019, pp. 1–7. Pubmed, doi:10.1016/j.ejphar.2018.12.010. Full Text
DiPalma, Devon, et al. “Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin.” Pharmacol Biochem Behav, vol. 176, Jan. 2019, pp. 16–22. Pubmed, doi:10.1016/j.pbb.2018.11.002. Full Text
Rezvani, Amir H., and Edward D. Levin. “Assessment of pregnenolone effects on alcohol intake and preference in male alcohol preferring (P) rats.” Eur J Pharmacol, vol. 740, 2014, pp. 53–57. Pubmed, doi:10.1016/j.ejphar.2014.07.003. Full Text