Andrew Darrell Krystal
Professor Emeritus of Psychiatry and Behavioral Sciences
Overview
Selected Grants
Obstructive Sleep Apnea Screening in Pregnant Women with Chronic Hypertension awarded by Society for Obstetric Anesthesia and Perinatology (Significant Contributor). 2017 to 2020
KOR Phase 2A Study - Mod 3 (Advanced Understanding) awarded by National Institutes of Health (Principal Investigator). 2014 to 2017
Modified KOR Phase 2A Study awarded by National Institutes of Health (Principal Investigator). 2014 to 2017
Study to Evaulate the Kappa Opioid Receptor as a Target for the Treatment of Mood and Anxiety Spectrum Disorders by Evaluating Whether LY2456302 Engages Reward-related Neural Circuitry. awarded by National Institutes of Health (Principal Investigator). 2013 to 2017
Janssen OBSERVEMDD0001 awarded by Janssen Research & Development, LLC (Principal Investigator). 2015 to 2017
2/3 Reducing Suicide Ideation Through Insomnia Treatment (REST-IT) awarded by National Institutes of Health (Principal Investigator). 2012 to 2017
Multicenter Study of the Safety and Efficacy of JZP-110 awarded by Jazz Pharmaceuticals (Principal Investigator). 2015 to 2017
Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear awarded by National Institutes of Health (Principal Investigator). 2015 to 2017
The Duke Multidisciplinary Training Program in Pediatric Lung Disease awarded by National Institutes of Health (Faculty Member). 2010 to 2016
An Open-Label and Double-Blind Study to Investigate Evoked Potentials as Markers of Ketamine-Induced Cortical Plasticity awarded by Janssen Research & Development, LLC (Principal Investigator). 2013 to 2015
Pages
Krystal, A. D. “Benzodiazepine receptor agonists: Indications, efficacy, and outcome.” Insomnia: Diagnosis and Treatment, 2016, pp. 375–86.
Krystal, A. D. “Psychiatric disorders and EEG.” Niedermeyer’s Electroencephalography: Basic Principles, Clinical Applications, and Related Fields: Sixth Edition, 2012, pp. 1113–27.
Krystal, A. D. “Sleep and psychiatric disorders.” Handbook of Sleep Medicine, 2011.
Low, Y., and A. D. Krystal. “Daytime sleepiness in insomnia patients.” Sleepiness: Causes, Consequences and Treatment, 2011, pp. 168–75. Scopus, doi:10.1017/CBO9780511762697.018. Full Text
Krystal, A. D. “Pharmacologic Treatment: Other Medications.” Principles and Practice of Sleep Medicine: Fifth Edition, 2010, pp. 916–30. Scopus, doi:10.1016/B978-1-4160-6645-3.00082-7. Full Text
Krystal, A. D. “Geriatric psychopharmacology: An overview.” Principles and Practice of Geriatric Sleep Medicine, 2009, pp. 327–31. Scopus, doi:10.1017/CBO9780511770661.034. Full Text
Richey, S. M., and A. D. Krystal. “Sleep medications: When to prescribe and rationale for use.” Sleep Disorders: Diagnosis and Therapeutics, 2008, pp. 268–80.
Culpepper, Larry, et al. “Post Hoc Analysis of the Impact of Lemborexant on Patient-Reported Sleep and Insomnia Severity in Adults with Insomnia and Depression Histories.” Cns Spectr, vol. 27, no. 2, Apr. 2022, p. 243. Pubmed, doi:10.1017/S1092852922000499. Full Text
Felder, J. N., et al. “Examining Experiences of Poor Sleep During Pregnancy: A Qualitative Study to Inform the Development of a Prenatal Sleep Intervention.” Global Advances in Health and Medicine, vol. 11, Mar. 2022. Scopus, doi:10.1177/2164957X221087655. Full Text
Whitehurst, Lauren N., et al. “Links between the brain and body during sleep: implications for memory processing.” Trends Neurosci, vol. 45, no. 3, Mar. 2022, pp. 212–23. Pubmed, doi:10.1016/j.tins.2021.12.007. Full Text
Sforzini, Luca, et al. “A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials.” Mol Psychiatry, vol. 27, no. 3, Mar. 2022, pp. 1286–99. Pubmed, doi:10.1038/s41380-021-01381-x. Full Text
Felder, Jennifer N., et al. “Randomized controlled trial of digital cognitive behavior therapy for prenatal insomnia symptoms: effects on postpartum insomnia and mental health.” Sleep, vol. 45, no. 2, Feb. 2022. Pubmed, doi:10.1093/sleep/zsab280. Full Text
Arnedt, J. Todd, et al. “Telemedicine-delivered cognitive-behavioral therapy for insomnia in alcohol use disorder (AUD): study protocol for a randomized controlled trial.” Trials, vol. 23, no. 1, Jan. 2022, p. 59. Pubmed, doi:10.1186/s13063-021-05898-y. Full Text
Wickwire, Emerson M., et al. “Trajectories of Insomnia in Adults After Traumatic Brain Injury.” Jama Netw Open, vol. 5, no. 1, Jan. 2022, p. e2145310. Pubmed, doi:10.1001/jamanetworkopen.2021.45310. Full Text
Lunsford-Avery, Jessica R., et al. “Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.” Nat Sci Sleep, vol. 14, 2022, pp. 217–30. Pubmed, doi:10.2147/NSS.S330939. Full Text
Krystal, Andrew D., et al. “What Is Insomnia?” Jama, vol. 326, no. 23, Dec. 2021, p. 2444. Pubmed, doi:10.1001/jama.2021.19283. Full Text
McCall, William V., et al. “Examining suicide assessment measures for research use: Using item response theory to optimize psychometric assessment for research on suicidal ideation in major depressive disorder.” Suicide Life Threat Behav, vol. 51, no. 6, Dec. 2021, pp. 1086–94. Pubmed, doi:10.1111/sltb.12791. Full Text
Pages
Scangos, Katherine, et al. “Corticocortical Evoked Potentials and Patient Response Reveal Networks Underlying Depression.” Biological Psychiatry, vol. 87, no. 9, 2020, pp. S157–S157.
Lunsford-Avery, J. R., et al. “SLEEP ASSOCIATED WITH EXECUTIVE FUNCTIONING AMONG ADOLESCENTS ACROSS THE ADHD CONTINUUM.” Sleep, vol. 43, 2020, pp. A373–A373.
McCall, W. V., et al. “DO THE SUBJECTIVE EFFECTS OF HYPNOTIC MEDICATIONS RESULT IN UNBLINDING OF TREATMENT ASSIGNMENT IN HYPNOTIC RANDOMIZED CLINICAL TRIALS?” Sleep, vol. 43, 2020, pp. A181–A181.
Ohayon, M. M., et al. “FACTORS ASSOCIATED WITH THE CONTINUOUS USE OF PSYCHOTROPIC TREATMENTS FOR NARCOLEPSY.” Sleep, vol. 43, 2020, pp. A294–A294.
Ohayon, M. M., and A. D. Krystal. “SLEEP IMPACTS OF NOCTURIA IN A LONGITUDINAL STUDY.” Sleep Medicine, vol. 64, 2019, pp. S284–85.
Ohayon, Maurice M., et al. “Narcolepsy Symptoms are Highly Persistent over Time Despite Treatment.” Annals of Neurology, vol. 86, WILEY, 2019, pp. S122–S122.
Ohayon, Maurice M., et al. “Longitudinal Assessment of Psychotropic Treatments for Narcolepsy.” Annals of Neurology, vol. 86, WILEY, 2019, pp. S212–S212.
Doghramji, Karl, et al. “PITOLISANT IN COMBINATION WITH OTHER MEDICATIONS FOR THE MANAGEMENT OF NARCOLEPSY.” Sleep, vol. 42, OXFORD UNIV PRESS INC, 2019.
Ohayon, Maurice M., et al. “Longitudinal Evolution of Narcolepsy Symptoms in Simplex and Multiplex Families.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S129–30.
Beaulieu-Bonneau, S., et al. “Weekly changes in sleep and insomnia symptoms during acute treatment of persistent insomnia with behavioural or pharmacological therapy.” Journal of Sleep Research, vol. 27, WILEY, 2018.