Andrew Darrell Krystal
Professor Emeritus of Psychiatry and Behavioral Sciences
Obstructive Sleep Apnea Screening in Pregnant Women with Chronic Hypertension awarded by Society for Obstetric Anesthesia and Perinatology (Significant Contributor). 2017 to 2020
KOR Phase 2A Study - Mod 3 (Advanced Understanding) awarded by National Institutes of Health (Principal Investigator). 2014 to 2017
Modified KOR Phase 2A Study awarded by National Institutes of Health (Principal Investigator). 2014 to 2017
Study to Evaulate the Kappa Opioid Receptor as a Target for the Treatment of Mood and Anxiety Spectrum Disorders by Evaluating Whether LY2456302 Engages Reward-related Neural Circuitry. awarded by National Institutes of Health (Principal Investigator). 2013 to 2017
Janssen OBSERVEMDD0001 awarded by Janssen Research & Development, LLC (Principal Investigator). 2015 to 2017
2/3 Reducing Suicide Ideation Through Insomnia Treatment (REST-IT) awarded by National Institutes of Health (Principal Investigator). 2012 to 2017
Multicenter Study of the Safety and Efficacy of JZP-110 awarded by Jazz Pharmaceuticals (Principal Investigator). 2015 to 2017
Transcranial Direct Current Stimulation (tDCS) as a Treatment for Acute Fear awarded by National Institutes of Health (Principal Investigator). 2015 to 2017
The Duke Multidisciplinary Training Program in Pediatric Lung Disease awarded by National Institutes of Health (Faculty Member). 2010 to 2016
An Open-Label and Double-Blind Study to Investigate Evoked Potentials as Markers of Ketamine-Induced Cortical Plasticity awarded by Janssen Research & Development, LLC (Principal Investigator). 2013 to 2015
Krystal, A. D. “Benzodiazepine receptor agonists: Indications, efficacy, and outcome.” Insomnia: Diagnosis and Treatment, 2016, pp. 375–86.
Krystal, A. D. “Psychiatric disorders and EEG.” Niedermeyer’s Electroencephalography: Basic Principles, Clinical Applications, and Related Fields: Sixth Edition, 2012, pp. 1113–27.
Krystal, A. D. “Sleep and psychiatric disorders.” Handbook of Sleep Medicine, 2011.
Richey, S. M., and A. D. Krystal. “Sleep medications: When to prescribe and rationale for use.” Sleep Disorders: Diagnosis and Therapeutics, 2008, pp. 268–80.
Hatch, Guy M., et al. “Is cellular energy monitoring more responsive to hypoxia than pulse oximetry?” Sleep Breath, vol. 24, no. 4, Dec. 2020, pp. 1633–43. Pubmed, doi:10.1007/s11325-020-02104-2. Full Text
Shi, Guangsen, et al. “Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait.” Curr Biol, Oct. 2020. Pubmed, doi:10.1016/j.cub.2020.09.071. Full Text
Lunsford-Avery, Jessica R., et al. “Feasibility and Acceptability of Wearable Sleep Electroencephalogram Device Use in Adolescents: Observational Study.” Jmir Mhealth Uhealth, vol. 8, no. 10, Oct. 2020, p. e20590. Pubmed, doi:10.2196/20590. Full Text
Krystal, Andrew D., et al. “Chronobiologic parameter changes in patients with major depressive disorder and sleep disturbance treated with adjunctive brexpiprazole: An open-label, flexible-dose, exploratory substudy.” J Affect Disord, vol. 278, Sept. 2020, pp. 288–95. Pubmed, doi:10.1016/j.jad.2020.09.026. Full Text
Pizzagalli, Diego A., et al. “Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).” Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 45, no. 10, Sept. 2020, pp. 1656–63. Epmc, doi:10.1038/s41386-020-0738-4. Full Text
Rumble, Meredith E., et al. “An exploratory analysis of the association of circadian rhythm dysregulation and insomnia with suicidal ideation over the course of treatment in individuals with depression, insomnia, and suicidal ideation.” Journal of Clinical Sleep Medicine : Jcsm : Official Publication of the American Academy of Sleep Medicine, vol. 16, no. 8, Aug. 2020, pp. 1311–19. Epmc, doi:10.5664/jcsm.8508. Full Text
Morin, Charles M., et al. “Effectiveness of Sequential Psychological and Medication Therapies for Insomnia Disorder: A Randomized Clinical Trial.” Jama Psychiatry, July 2020. Pubmed, doi:10.1001/jamapsychiatry.2020.1767. Full Text
Krystal, Andrew D., et al. “A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.” Nat Med, vol. 26, no. 5, May 2020, pp. 760–68. Pubmed, doi:10.1038/s41591-020-0806-7. Full Text
Doghramji, Karl, et al. “PITOLISANT IN COMBINATION WITH OTHER MEDICATIONS FOR THE MANAGEMENT OF NARCOLEPSY.” Sleep, vol. 42, OXFORD UNIV PRESS INC, 2019.
Ohayon, Maurice M., et al. “Longitudinal Evolution of Narcolepsy Symptoms in Simplex and Multiplex Families.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S129–30.
Beaulieu-Bonneau, S., et al. “Weekly changes in sleep and insomnia symptoms during acute treatment of persistent insomnia with behavioural or pharmacological therapy.” Journal of Sleep Research, vol. 27, WILEY, 2018.
Lunsford-Avery, J. R., et al. “SLEEPING AT HOME: FEASIBILITY AND TOLERABILITY OF AMBULATORY POLYSOMNOGRAPHY FOR USE WITH ADOLESCENTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER.” Sleep, vol. 41, OXFORD UNIV PRESS INC, 2018, pp. A283–84.
Blanco, Marina B., et al. “To arouse or not to arouse: physiological responses from active thermogenesis versus thermoconforming in hibernating dwarf lemurs.” American Journal of Physical Anthropology, vol. 165, WILEY, 2018, pp. 30–30.
Rumble, M. E., et al. “A PRELIMINARY REPORT FROM THE "REST-IT" STUDY: SELF-REPORTED EVENINGNESS AND ACTIGRAPHIC DELAYED SLEEP TIMING CORRELATE WITH SUICIDAL IDEATION IN INDIVIDUALS WITH DEPRESSION AND INSOMNIA.” Sleep, vol. 41, OXFORD UNIV PRESS INC, 2018, pp. A237–38.
Morin, C. M., et al. “0341 SEQUENTIAL THERAPIES FOR COMORBID AND PRIMARY INSOMNIA: A RANDOMIZED CONTROLLED TRIAL.” Sleep, vol. 40, no. suppl_1, Oxford University Press (OUP), 2017, pp. A127–A127. Crossref, doi:10.1093/sleepj/zsx050.340. Full Text
Edinger, J. D., et al. “0335 DOES OBJECTIVE SLEEP DURATION MODERATE TREATMENT RESPONSE IN PATIENT WITH COMORBID DEPRESSION AND INSOMNIA? A REPORT FROM THE TRIAD STUDY.” Sleep, vol. 40, no. suppl_1, Oxford University Press (OUP), 2017, pp. A124–A124. Crossref, doi:10.1093/sleepj/zsx050.334. Full Text
Sateia, M. J., et al. “0395 CLINICAL PRACTICE GUIDELINE FOR THE PHARMACOLOGIC TREATMENT OF CHRONIC INSOMNIA IN ADULTS: AN AMERICAN ACADEMY OF SLEEP MEDICINE CLINICAL PRACTICE GUIDELINE.” Sleep, vol. 40, no. suppl_1, Oxford University Press (OUP), 2017, pp. A147–A147. Crossref, doi:10.1093/sleepj/zsx050.394. Full Text