Anne Elizabeth West

Anne Elizabeth West

Professor of Neurobiology

External Address: 
Bryan Research Building, 311 Research Drive Room 301D, Durham, NC 27710
Internal Office Address: 
Box 3209, Durham, NC 27710
Phone: 
919.681.1909

Overview

The long term goal of our laboratory is to understand at a cellular/molecular level how neuronal activity regulates the formation and maturation of synapses during brain development, and ultimately to use genetic model systems to understand how defects in this developmental process lead to cognitive dysfunction.

Education & Training

  • Ph.D., Harvard University 1998

  • M.D., Harvard University 1998

  • B.A., Cornell University 1989

Selected Grants

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Pharmacological Sciences Training Grant awarded by National Institutes of Health (Preceptor). 2020 to 2025

Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Psychostimulant-Induced Plasticity of Nucleus Accumbens Interneurons awarded by National Institutes of Health (Principal Investigator). 2019 to 2024

Modulation of the Perineuronal Net Protein Brevican in the Nucleus Accumbens, and its Impact on Addiction-like Behavior awarded by National Institutes of Health (Principal Investigator). 2020 to 2023

Epigenomic modulation of psychostimulant-inducible Fosb in the nucleus accumbens awarded by National Institutes of Health (Principal Investigator). 2020 to 2023

Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse awarded by National Institutes of Health (Collaborating Investigator). 2018 to 2023

The Role of the Lysine-Specific Histone Demethylase 6b, Kdm6b In Synapse Maturation awarded by National Institutes of Health (Principal Investigator). 2019 to 2022

Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022

IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation (Mentor). 2019 to 2022

Pages

Chen, Liang-Fu, et al. “The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription.J Biol Chem, vol. 295, no. 25, June 2020, pp. 8613–27. Pubmed, doi:10.1074/jbc.RA119.010266. Full Text Open Access Copy

Nord, Alex S., and Anne E. West. “Neurobiological functions of transcriptional enhancers.Nat Neurosci, vol. 23, no. 1, Jan. 2020, pp. 5–14. Pubmed, doi:10.1038/s41593-019-0538-5. Full Text

Swahari, Vijay, and Anne E. West. “Histone demethylases in neuronal differentiation, plasticity, and disease.Curr Opin Neurobiol, vol. 59, Dec. 2019, pp. 9–15. Pubmed, doi:10.1016/j.conb.2019.02.009. Full Text

West, Anne E. “Activity-Dependent Transcription Collaborates with Local Dendritic Translation to Encode Stimulus-Specificity in the Genome Binding of NPAS4.Neuron, vol. 104, no. 4, Nov. 2019, pp. 634–36. Pubmed, doi:10.1016/j.neuron.2019.10.022. Full Text

Tonn Eisinger, Katherine R., and Anne E. West. “Transcribing Memories in Genome Architecture.Trends Neurosci, vol. 42, no. 9, Sept. 2019, pp. 565–66. Pubmed, doi:10.1016/j.tins.2019.06.002. Full Text

Kim, Namsoo, et al. “A striatal interneuron circuit for continuous target pursuit.Nat Commun, vol. 10, no. 1, June 2019, p. 2715. Pubmed, doi:10.1038/s41467-019-10716-w. Full Text

Chen, Liang-Fu, et al. “Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.Cell Rep, vol. 26, no. 5, Jan. 2019, pp. 1174-1188.e5. Pubmed, doi:10.1016/j.celrep.2019.01.032. Full Text

Gallegos, David A., et al. “Chromatin Regulation of Neuronal Maturation and Plasticity.Trends Neurosci, vol. 41, no. 5, May 2018, pp. 311–24. Pubmed, doi:10.1016/j.tins.2018.02.009. Full Text

Wang, Xiaoting, et al. “Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference.Neuropsychopharmacology, vol. 43, no. 5, Apr. 2018, pp. 953–63. Pubmed, doi:10.1038/npp.2017.178. Full Text

Wijayatunge, Ranjula, et al. “The histone demethylase Kdm6b regulates a mature gene expression program in differentiating cerebellar granule neurons.Mol Cell Neurosci, vol. 87, Mar. 2018, pp. 4–17. Pubmed, doi:10.1016/j.mcn.2017.11.005. Full Text

Pages

West, Anne E. “Insights into the Roles of the Methyl-DNA Binding Protein MeCP2 in Addictive-like Behaviors.” Neuropsychopharmacology, vol. 38, NATURE PUBLISHING GROUP, 2013, pp. S59–60.

Zannas, Anthony S., et al. “Phosphorylation of MeCP2 in Reward-Related Circuits is Required for Amphetamine-Induced Conditioned Place Preference in Mice.” Biological Psychiatry, vol. 73, no. 9, ELSEVIER SCIENCE INC, 2013, pp. 285S-285S.