Anne Elizabeth West

Anne Elizabeth West

Professor of Neurobiology

External Address: 
Bryan Research Building, 311 Research Drive Room 301D, Durham, NC 27710
Internal Office Address: 
Box 3209, Durham, NC 27710
Phone: 
919.681.1909

Overview

The long term goal of our laboratory is to understand at a cellular/molecular level how neuronal activity regulates the formation and maturation of synapses during brain development, and ultimately to use genetic model systems to understand how defects in this developmental process lead to cognitive dysfunction.

Education & Training

  • Ph.D., Harvard University 1998

  • M.D., Harvard University 1998

  • B.A., Cornell University 1989

Selected Grants

Cell and Molecular Biology Training Program awarded by National Institutes of Health (Mentor). 2021 to 2026

Pharmacological Sciences Training Grant awarded by National Institutes of Health (Preceptor). 2020 to 2025

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Noncoding regulation of gene transcription in human neurons awarded by Ruth K. Broad Biomedical Research Foundation (Principal Investigator). 2021 to 2024

Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Functional and Mechanistic Dissection of GPCR Endosomal Signaling Dynamics awarded by National Institutes of Health (Collaborator). 2021 to 2024

Psychostimulant-Induced Plasticity of Nucleus Accumbens Interneurons awarded by National Institutes of Health (Principal Investigator). 2019 to 2024

Modulation of the Perineuronal Net Protein Brevican in the Nucleus Accumbens, and its Impact on Addiction-like Behavior awarded by National Institutes of Health (Principal Investigator). 2020 to 2023

Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse awarded by National Institutes of Health (Collaborating Investigator). 2018 to 2023

The Role of the Lysine-Specific Histone Demethylase 6b, Kdm6b In Synapse Maturation awarded by National Institutes of Health (Principal Investigator). 2019 to 2022

Pages

Gemberling, Matthew P., et al. “Transgenic mice for in vivo epigenome editing with CRISPR-based systems.Nat Methods, vol. 18, no. 8, Aug. 2021, pp. 965–74. Pubmed, doi:10.1038/s41592-021-01207-2. Full Text

Chan, Urann, et al. “Utilizing In Vivo Postnatal Electroporation to Study Cerebellar Granule Neuron Morphology and Synapse Development.J Vis Exp, no. 172, June 2021. Pubmed, doi:10.3791/62568. Full Text

Green, Matthew V., and Anne E. West. “TRPing into excitotoxic neuronal death.Cell Calcium, vol. 93, Jan. 2021, p. 102331. Pubmed, doi:10.1016/j.ceca.2020.102331. Full Text

Chen, Liang-Fu, et al. “The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription.J Biol Chem, vol. 295, no. 25, June 2020, pp. 8613–27. Pubmed, doi:10.1074/jbc.RA119.010266. Full Text Open Access Copy

Nord, Alex S., and Anne E. West. “Neurobiological functions of transcriptional enhancers.Nat Neurosci, vol. 23, no. 1, Jan. 2020, pp. 5–14. Pubmed, doi:10.1038/s41593-019-0538-5. Full Text

Swahari, Vijay, and Anne E. West. “Histone demethylases in neuronal differentiation, plasticity, and disease.Curr Opin Neurobiol, vol. 59, Dec. 2019, pp. 9–15. Pubmed, doi:10.1016/j.conb.2019.02.009. Full Text

West, Anne E. “Activity-Dependent Transcription Collaborates with Local Dendritic Translation to Encode Stimulus-Specificity in the Genome Binding of NPAS4.Neuron, vol. 104, no. 4, Nov. 2019, pp. 634–36. Pubmed, doi:10.1016/j.neuron.2019.10.022. Full Text

Tonn Eisinger, Katherine R., and Anne E. West. “Transcribing Memories in Genome Architecture.Trends Neurosci, vol. 42, no. 9, Sept. 2019, pp. 565–66. Pubmed, doi:10.1016/j.tins.2019.06.002. Full Text

Kim, Namsoo, et al. “A striatal interneuron circuit for continuous target pursuit.Nat Commun, vol. 10, no. 1, June 2019, p. 2715. Pubmed, doi:10.1038/s41467-019-10716-w. Full Text

Chen, Liang-Fu, et al. “Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.Cell Rep, vol. 26, no. 5, Jan. 2019, pp. 1174-1188.e5. Pubmed, doi:10.1016/j.celrep.2019.01.032. Full Text

Pages

West, Anne E. “Insights into the Roles of the Methyl-DNA Binding Protein MeCP2 in Addictive-like Behaviors.” Neuropsychopharmacology, vol. 38, NATURE PUBLISHING GROUP, 2013, pp. S59–60.

Zannas, Anthony S., et al. “Phosphorylation of MeCP2 in Reward-Related Circuits is Required for Amphetamine-Induced Conditioned Place Preference in Mice.” Biological Psychiatry, vol. 73, no. 9, ELSEVIER SCIENCE INC, 2013, pp. 285S-285S.