Christina S. Meade
Associate Professor in Psychiatry and Behavioral Sciences
Overview
Dr. Meade’s domestic research program focuses on predictors of HIV risk behavior in adults with substance use and psychiatric disorders, and the relationship between neuropsychiatric conditions and continued risk behavior in HIV-positive adults. She is particularly interested in how drug addiction and HIV infection impact executive functions, such as decision making, that lead individuals to engage in risky behaviors. Many of her current projects incorporate MRI to isolate the effects of addiction and HIV on both brain function and structure. Dr. Meade is also interested in the development of evidence-based treatments to improve cognitive functioning and reduce risk behaviors among drug users.
Given that most people infected or affected by HIV/AIDS live in Sub-Saharan Africa, Dr. Meade’s international research program is based in South Africa. The Western Cape has experienced a dramatic increase in methamphetamine use since the early 2000s, and there is concern that it may further fuel the HIV epidemic in this country. Current projects focus on characterizing drug addiction and HIV risk behaviors in this understudied group, both in in community and treatment settings, and ultimately increasing uptake of HIV services to improve health outcomes and reduce the continued spread of HIV.
Selected Grants
Modeling the effects of chronic marijuana use on neuroinflammation and HIV-related neuronal injury awarded by National Institutes of Health (Principal Investigator). 2020 to 2025
Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health (Mentor). 2010 to 2025
Role of cannabis on HIV-related cognitive impairment: a brain connectomics study awarded by National Institutes of Health (Principal Investigator). 2018 to 2024
MRI data fusion to investigate effects of drug abuse on HIV neurological complications awarded by National Institutes of Health (Principal Investigator). 2018 to 2023
Mobile health interventions for varenicline adherence among HIV-positive smokers awarded by National Institutes of Health (Co-Mentor). 2017 to 2022
A High-Performance 3T MRI for Brain Imaging awarded by National Institutes of Health (Major User). 2021 to 2022
A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health (Co-Principal Investigator). 2016 to 2021
Decision Making and HIV Risk: New Approaches to neuroAIDS Research in Drug Users awarded by National Institutes of Health (Principal Investigator). 2015 to 2021
Testing a Biopsychosocial Model of Minority Stress and Health for HIV-Positive Men awarded by Research Foundation of The City University of New York (Principal Investigator). 2019 to 2021
Cognitive Training to Reduce Impulsivity in HIV-infected Cocaine Users awarded by National Institutes of Health (Principal Investigator). 2016 to 2019
Pages
Miles, M. S., et al. “Emotional distress in african american women with hiv.” HIV: Issues with Mental Health and Illness, 2014, pp. 35–50. Scopus, doi:10.4324/9781315785509. Full Text
Sikkema, Kathleen J., et al. Community-level HIV prevention for persons with severe mental illness living in supportive housing programs: a pilot intervention study. Vol. 33, 2007, pp. 121–35. Pubmed, doi:10.1300/J005v33n01_10. Full Text
Hall, Shana A., et al. “Strengthened and posterior-shifted structural rich-club organization in people who use cocaine.” Drug Alcohol Depend, vol. 235, June 2022, p. 109436. Pubmed, doi:10.1016/j.drugalcdep.2022.109436. Full Text
Bell, Ryan P., et al. “Principal component analysis denoising improves sensitivity of MR diffusion to detect white matter injury in neuroHIV.” J Neuroimaging, vol. 32, no. 3, May 2022, pp. 544–53. Pubmed, doi:10.1111/jon.12965. Full Text
Baum, Marianna K., et al. “HIV, psychological resilience, and substance misuse during the COVID-19 pandemic: A multi-cohort study.” Drug Alcohol Depend, vol. 231, Feb. 2022, p. 109230. Pubmed, doi:10.1016/j.drugalcdep.2021.109230. Full Text
Xu, Yunan, et al. “Effects of substance use on monetary delay discounting among people who use stimulants with and without HIV: An ecological momentary assessment study.” Exp Clin Psychopharmacol, vol. 30, no. 1, Feb. 2022, pp. 39–50. Pubmed, doi:10.1037/pha0000423. Full Text
Carney, Tara, et al. “Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling.” Plos One, vol. 17, no. 2, 2022, p. e0262440. Pubmed, doi:10.1371/journal.pone.0262440. Full Text
Hall, Shana A., et al. “Human immunodeficiency virus-related decreases in corpus callosal integrity and corresponding increases in functional connectivity.” Hum Brain Mapp, vol. 42, no. 15, Oct. 2021, pp. 4958–72. Pubmed, doi:10.1002/hbm.25592. Full Text
Sui, Jing, et al. “Structural and Functional Brain Abnormalities in Human Immunodeficiency Virus Disease Revealed by Multimodal Magnetic Resonance Imaging Fusion: Association With Cognitive Function.” Clin Infect Dis, vol. 73, no. 7, Oct. 2021, pp. e2287–93. Pubmed, doi:10.1093/cid/ciaa1415. Full Text
Chen, Nan-Kuei, et al. “On the down-sampling of diffusion MRI data along the angular dimension.” Magn Reson Imaging, vol. 82, Oct. 2021, pp. 104–10. Pubmed, doi:10.1016/j.mri.2021.06.012. Full Text
Meade, Christina S., et al. “Brain multimodal co-alterations related to delay discounting: a multimodal MRI fusion analysis in persons with and without cocaine use disorder.” Bmc Neurosci, vol. 22, no. 1, Aug. 2021, p. 51. Pubmed, doi:10.1186/s12868-021-00654-z. Full Text
Xu, Yunan, et al. “Using mobile health technologies to test the association of cocaine use with sexual desire and risky sexual behaviors among people with and without HIV who use illicit stimulants.” Drug Alcohol Depend, vol. 225, Aug. 2021, p. 108744. Pubmed, doi:10.1016/j.drugalcdep.2021.108744. Full Text
Pages
Hobkirk, Andrea L., et al. “FOOD INSECURITY IS ASSOCIATED WITH NEUROCOGNITIVE IMPAIRMENT AMONG INDIVIDUALS LIVING WITH HIV.” Annals of Behavioral Medicine, vol. 50, OXFORD UNIV PRESS INC, 2016, pp. S246–S246.