Court Alan Hull

Court Alan Hull

Associate Professor of Neurobiology

External Address: 
Bryan Research Building, 311 Research Drive Room 427C, Durham, NC 27710
Internal Office Address: 
Box 3209, Durham, NC 27710
Phone: 
919.613.0927

Overview

We study neural circuits in the rodent cerebellum involved with motor timing, coordination, and learning.  Our approaches include high-speed multiphoton imaging from cerebellar neurons in vivo during behavior, extracellular and intracellular electrophysiology in vivo as well as in acute brain slices, and anatomical techniques such as cell type-specific viral labeling to identify functional circuit pathways that connect the cerebellum with other brain regions. 

Education & Training

  • Ph.D., Oregon Health and Science University 2005

Selected Grants

Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Canonical computations for motor learning by the cerebellar cortex micro-circuit awarded by National Institutes of Health (Co-Principal Investigator). 2019 to 2024

Role of ASTN2 in cerebellar circuit function and ASD-related behaviors awarded by Rockefeller University (Principal Investigator). 2020 to 2022

Circuit mechanisms of reward prediction in the cerebellum awarded by Ruth K. Broad Biomedical Research Foundation (Principal Investigator). 2021 to 2022

Neuromodulatory Control of Cerebellar Synaptic Processing and Sensory Input awarded by National Institutes of Health (Principal Investigator). 2016 to 2021

Evaluating how inhibition shapes granule cell population codes awarded by National Institutes of Health (Principal Investigator). 2021

Re-examining the role of cerebellar climbing fibers in motor learning awarded by National Institutes of Health (Principal Investigator). 2017 to 2019

Basic predoctoral training in neuroscience awarded by National Institutes of Health (Training Faculty). 1992 to 2018

Representation of Time in the Cerebellar Cortex awarded by Whitehall Foundation, Inc. (Principal Investigator). 2014 to 2017

Representation of time in the cerebellar cortex awarded by Alfred P. Sloan Foundation (Principal Investigator). 2014 to 2016

Fore, Taylor R., et al. “Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition.J Neurosci, vol. 40, no. 14, Apr. 2020, pp. 2882–94. Pubmed, doi:10.1523/JNEUROSCI.2148-19.2020. Full Text Open Access Copy

Hull, Court. “Prediction signals in the cerebellum: beyond supervised motor learning.Elife, vol. 9, Mar. 2020. Pubmed, doi:10.7554/eLife.54073. Full Text

Heffley, William, and Court Hull. “Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum.Elife, vol. 8, Sept. 2019. Pubmed, doi:10.7554/eLife.46764. Full Text

Fleming, Elizabeth, and Court Hull. “Serotonin regulates dynamics of cerebellar granule cell activity by modulating tonic inhibition.J Neurophysiol, vol. 121, no. 1, Jan. 2019, pp. 105–14. Pubmed, doi:10.1152/jn.00492.2018. Full Text

Behesti, Hourinaz, et al. “ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins.Proc Natl Acad Sci U S A, vol. 115, no. 41, Oct. 2018, pp. E9717–26. Pubmed, doi:10.1073/pnas.1809382115. Full Text

Heffley, William, et al. “Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.Nat Neurosci, vol. 21, no. 10, Oct. 2018, pp. 1431–41. Pubmed, doi:10.1038/s41593-018-0228-8. Full Text

Hull, Court. “The cerebellum influences vocal timing.Elife, vol. 7, Aug. 2018. Pubmed, doi:10.7554/eLife.40447. Full Text

Hull, Court. “Cellular and Synaptic Properties of Local Inhibitory Circuits.Cold Spring Harb Protoc, vol. 2017, no. 5, May 2017. Pubmed, doi:10.1101/pdb.top095281. Full Text

Pages