Craig S. Henriquez

Craig S. Henriquez

Professor of Biomedical Engineering

External Address: 
274 Hudson Hall Annex, Durham, NC 27708
Internal Office Address: 
Duke Box 90281, Durham, NC 27708-0281
Phone: 
919.660.5168
Email: 

Overview

Dr. Henriquez is also a Professor of Computer Science and Co-Director of the Center for Neuroengineering. Henriquez's research interests include large scale computing, heart modeling, and brain modeling.

A breakdown of the normal electrical activation sequence of the heart can sometimes lead to a state of ventricular fibrillation in which the heart ceases to function as an effective pump. Abnormal rhythms or arrhythmias often result after an episode of ischemia (a localized reduction of blood flow to the heart itself) which affects both the ionic processes necessary to elicit an impulse and the passive electrical properties of the tissue. Identifying the complex mechanisms of arrhythmogenesis will require experimentation as well as mathematical and computer models.

Current projects include the application of the bidomain model to diseased tissue to investigate how changes in tissue structure (both natural and diseased induced) and changes in ionic current flow influences the nature of conduction and the onset of arrhythmia.

Dr. Henriquez's group is also interested in developing realistic models that will enable investigators to better interpret electrophysiological measurements made in the clinic. For example, activation maps at the surface of the heart are typically constructed based on the detection of specific features of the surface extracellular recordings. However, for complex activation, such as might arise during an arrhythmia, the features are difficult to distinguish.

The use of models that simulate both activation and the resulting extracellular potential and the application of signal processing techniques can lead to a tool for constructing more meaningful maps from experimental recordings during abnormal conduction. This works involves direct interaction with experimental research performed in the Experimental Electrophysiology Laboratory under the direction of Dr. Patrick Wolf and the Cardiac Electrophysiology & Tissue Engineering lab under the direction of Dr. Nenad Bursac.

Education & Training

  • Ph.D., Duke University 1988

  • B.S., Duke University 1981

Ferrari, S., et al. “Biologically realizable reward-modulated hebbian training for spiking neural networks.” Proceedings of the International Joint Conference on Neural Networks, Nov. 2008, pp. 1780–86. Scopus, doi:10.1109/IJCNN.2008.4634039. Full Text

Roberts, Sarah F., et al. “Effect of nonuniform interstitial space properties on impulse propagation: a discrete multidomain model.Biophysical Journal, vol. 95, no. 8, Oct. 2008, pp. 3724–37. Epmc, doi:10.1529/biophysj.108.137349. Full Text

Jacquemet, Vincent, and Craig S. Henriquez. “Loading effect of fibroblast-myocyte coupling on resting potential, impulse propagation, and repolarization: insights from a microstructure model.American Journal of Physiology. Heart and Circulatory Physiology, vol. 294, no. 5, May 2008, pp. H2040–52. Epmc, doi:10.1152/ajpheart.01298.2007. Full Text

Jacquemet, Vincent, et al. “Modeling atrial arrhythmias: impact on clinical diagnosis and therapies.Ieee Reviews in Biomedical Engineering, vol. 1, Jan. 2008, pp. 94–114. Epmc, doi:10.1109/rbme.2008.2008242. Full Text

Jacquemet, V., and C. S. Henriquez. “An efficient technique for determining the steady-state membrane potential profile in tissues with multiple cell types.” Computers in Cardiology, vol. 34, Dec. 2007, pp. 113–16. Scopus, doi:10.1109/CIC.2007.4745434. Full Text

Stinstra, J. G., et al. “A model for estimating the anisotropy of the conduction velocity in cardiac tissue based on the tissue morphology.” Computers in Cardiology, vol. 34, Dec. 2007, pp. 129–32. Scopus, doi:10.1109/CIC.2007.4745438. Full Text

Ying, Wenjun, and Craig S. Henriquez. “A Kernel-free Boundary Integral Method for Elliptic Boundary Value Problems.Journal of Computational Physics, vol. 227, no. 2, Dec. 2007, pp. 1046–74. Epmc, doi:10.1016/j.jcp.2007.08.021. Full Text

Hubbard, Marjorie Letitia, et al. “Effect of gap junction distribution on impulse propagation in a monolayer of myocytes: a model study.Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 9 Suppl 6, Nov. 2007, pp. vi20–28. Epmc, doi:10.1093/europace/eum203. Full Text

Jacquemet, Vincent, and Craig S. Henriquez. “Modelling cardiac fibroblasts: interactions with myocytes and their impact on impulse propagation.Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 9 Suppl 6, Nov. 2007, pp. vi29–37. Epmc, doi:10.1093/europace/eum207. Full Text

Won, D. S., et al. “An analytical comparison of the information in sorted and non-sorted cosine-tuned spike activity.Journal of Neural Engineering, vol. 4, no. 3, Sept. 2007, pp. 322–35. Epmc, doi:10.1088/1741-2560/4/3/017. Full Text

Pages