Craig S. Henriquez

Craig S. Henriquez

Professor of Biomedical Engineering

External Address: 
274 Hudson Hall Annex, Durham, NC 27708
Internal Office Address: 
Duke Box 90281, Durham, NC 27708-0281


Dr. Henriquez is also a Professor of Computer Science and Co-Director of the Center for Neuroengineering. Henriquez's research interests include large scale computing, heart modeling, and brain modeling.

A breakdown of the normal electrical activation sequence of the heart can sometimes lead to a state of ventricular fibrillation in which the heart ceases to function as an effective pump. Abnormal rhythms or arrhythmias often result after an episode of ischemia (a localized reduction of blood flow to the heart itself) which affects both the ionic processes necessary to elicit an impulse and the passive electrical properties of the tissue. Identifying the complex mechanisms of arrhythmogenesis will require experimentation as well as mathematical and computer models.

Current projects include the application of the bidomain model to diseased tissue to investigate how changes in tissue structure (both natural and diseased induced) and changes in ionic current flow influences the nature of conduction and the onset of arrhythmia.

Dr. Henriquez's group is also interested in developing realistic models that will enable investigators to better interpret electrophysiological measurements made in the clinic. For example, activation maps at the surface of the heart are typically constructed based on the detection of specific features of the surface extracellular recordings. However, for complex activation, such as might arise during an arrhythmia, the features are difficult to distinguish.

The use of models that simulate both activation and the resulting extracellular potential and the application of signal processing techniques can lead to a tool for constructing more meaningful maps from experimental recordings during abnormal conduction. This works involves direct interaction with experimental research performed in the Experimental Electrophysiology Laboratory under the direction of Dr. Patrick Wolf and the Cardiac Electrophysiology & Tissue Engineering lab under the direction of Dr. Nenad Bursac.

Education & Training

  • Ph.D., Duke University 1988

  • B.S., Duke University 1981

Goodman, Amy M., et al. “A membrane model of electrically remodelled atrial myocardium derived from in vivo measurements.Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, vol. 7 Suppl 2, Sept. 2005, pp. 135–45. Epmc, doi:10.1016/j.eupc.2005.04.010. Full Text

Jacquemet, Vincent, and Craig S. Henriquez. “Finite volume stiffness matrix for solving anisotropic cardiac propagation in 2-D and 3-D unstructured meshes.Ieee Transactions on Bio Medical Engineering, vol. 52, no. 8, Aug. 2005, pp. 1490–92. Epmc, doi:10.1109/tbme.2005.851459. Full Text

Sampson, Kevin J., and Craig S. Henriquez. “Electrotonic influences on action potential duration dispersion in small hearts: a simulation study.American Journal of Physiology. Heart and Circulatory Physiology, vol. 289, no. 1, July 2005, pp. H350–60. Epmc, doi:10.1152/ajpheart.00507.2004. Full Text

Eaton, K. P., and C. S. Henriquez. “Confounded spikes generated by synchrony within neural tissue models.” Neurocomputing, vol. 65–66, no. SPEC. ISS., June 2005, pp. 851–57. Scopus, doi:10.1016/j.neucom.2004.10.082. Full Text

Lebedev, Mikhail A., et al. “Cortical ensemble adaptation to represent velocity of an artificial actuator controlled by a brain-machine interface.J Neurosci, vol. 25, no. 19, May 2005, pp. 4681–93. Pubmed, doi:10.1523/JNEUROSCI.4088-04.2005. Full Text

Oliver, Robert A., et al. “Bistability and correlation with arrhythmogenesis in a model of the right atrium.Annals of Biomedical Engineering, vol. 33, no. 5, May 2005, pp. 577–89. Epmc, doi:10.1007/s10439-005-1473-z. Full Text

Tranquillo, Joseph V., et al. “Analytical model of extracellular potentials in a tissue slab with a finite bath.Ieee Transactions on Bio Medical Engineering, vol. 52, no. 2, Feb. 2005, pp. 334–38. Epmc, doi:10.1109/tbme.2004.840467. Full Text

Tranquillo, Joseph V., et al. “Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients.American Journal of Physiology. Heart and Circulatory Physiology, vol. 286, no. 4, Apr. 2004, pp. H1370–81. Epmc, doi:10.1152/ajpheart.00803.2003. Full Text

Shao, Hai, et al. “A resistor interpretation of general anisotropic cardiac tissue.Mathematical Biosciences, vol. 187, no. 2, Feb. 2004, pp. 155–74. Epmc, doi:10.1016/j.mbs.2003.10.005. Full Text

Henriquez, C. S., et al. Three-dimensional propagation in mathematic models: Integrative model of the mouse heart. Jan. 2004, pp. 273–81. Scopus, doi:10.1016/B0-7216-0323-8/50033-6. Full Text