Craig S. Henriquez

Craig S. Henriquez

Professor of Biomedical Engineering

External Address: 
274 Hudson Hall Annex, Durham, NC 27708
Internal Office Address: 
Duke Box 90281, Durham, NC 27708-0281


Dr. Henriquez is also a Professor of Computer Science and Co-Director of the Center for Neuroengineering. Henriquez's research interests include large scale computing, heart modeling, and brain modeling.

A breakdown of the normal electrical activation sequence of the heart can sometimes lead to a state of ventricular fibrillation in which the heart ceases to function as an effective pump. Abnormal rhythms or arrhythmias often result after an episode of ischemia (a localized reduction of blood flow to the heart itself) which affects both the ionic processes necessary to elicit an impulse and the passive electrical properties of the tissue. Identifying the complex mechanisms of arrhythmogenesis will require experimentation as well as mathematical and computer models.

Current projects include the application of the bidomain model to diseased tissue to investigate how changes in tissue structure (both natural and diseased induced) and changes in ionic current flow influences the nature of conduction and the onset of arrhythmia.

Dr. Henriquez's group is also interested in developing realistic models that will enable investigators to better interpret electrophysiological measurements made in the clinic. For example, activation maps at the surface of the heart are typically constructed based on the detection of specific features of the surface extracellular recordings. However, for complex activation, such as might arise during an arrhythmia, the features are difficult to distinguish.

The use of models that simulate both activation and the resulting extracellular potential and the application of signal processing techniques can lead to a tool for constructing more meaningful maps from experimental recordings during abnormal conduction. This works involves direct interaction with experimental research performed in the Experimental Electrophysiology Laboratory under the direction of Dr. Patrick Wolf and the Cardiac Electrophysiology & Tissue Engineering lab under the direction of Dr. Nenad Bursac.

Education & Training

  • Ph.D., Duke University 1988

  • B.S., Duke University 1981

Carmena, Jose M., et al. “Learning to control a brain-machine interface for reaching and grasping by primates.Plos Biol, vol. 1, no. 2, Nov. 2003, p. E42. Pubmed, doi:10.1371/journal.pbio.0000042. Full Text

Jacquemet, Vincent, et al. “Study of unipolar electrogram morphology in a computer model of atrial fibrillation.Journal of Cardiovascular Electrophysiology, vol. 14, no. 10 Suppl, Oct. 2003, pp. S172–79. Epmc, doi:10.1046/j.1540.8167.90308.x. Full Text

Cherry, Elizabeth M., et al. “Efficient simulation of three-dimensional anisotropic cardiac tissue using an adaptive mesh refinement method.Chaos (Woodbury, N.Y.), vol. 13, no. 3, Sept. 2003, pp. 853–65. Epmc, doi:10.1063/1.1594685. Full Text

Zozor, Steeve, et al. “A numerical scheme for modeling wavefront propagation on a monolayer of arbitrary geometry.Ieee Transactions on Bio Medical Engineering, vol. 50, no. 4, Apr. 2003, pp. 412–20. Epmc, doi:10.1109/tbme.2003.809505. Full Text

Kappenberger, L., et al. “Proceedings of the Third International Workshop on Computer Simulation and Experimental Assessment of Cardiac Electrical Function: Foreword.” Journal of Cardiovascular Electrophysiology, vol. 14, no. 10 SUPPL., Jan. 2003. Scopus, doi:10.1046/j.1540.8167.90320.x. Full Text

Pormann, J. B., et al. “Large-scale modeling of cardiac electrophysiology.” Computers in Cardiology, vol. 29, Dec. 2002, pp. 259–62.

Tranquillo, J. V., et al. “Monophasic action potentials in murine heart: A model study.” Annual International Conference of the Ieee Engineering in Medicine and Biology  Proceedings, vol. 2, Dec. 2002, pp. 1415–16.

Knollmann, Björn C., et al. “Microelectrode study of the genesis of the monophasic action potential by contact electrode technique.Journal of Cardiovascular Electrophysiology, vol. 13, no. 12, Dec. 2002, pp. 1246–52. Epmc, doi:10.1046/j.1540-8167.2002.01246.x. Full Text

Virag, N., et al. “Study of atrial arrhythmias in a computer model based on magnetic resonance images of human atria.Chaos (Woodbury, N.Y.), vol. 12, no. 3, Sept. 2002, pp. 754–63. Epmc, doi:10.1063/1.1483935. Full Text

Sampson, Kevin J., and Craig S. Henriquez. “Interplay of ionic and structural heterogeneity on functional action potential duration gradients: Implications for arrhythmogenesis.Chaos (Woodbury, N.Y.), vol. 12, no. 3, Sept. 2002, pp. 819–28. Epmc, doi:10.1063/1.1497735. Full Text