David Samuel Warner
Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine
Duke CTSA (TL1) awarded by National Institutes of Health (Mentor). 2018 to 2023
The Unfolded Protein Response and Neuroprotection in Stroke awarded by National Institutes of Health (Significant Contributor). 2016 to 2021
Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Principal Investigator). 1996 to 2021
Pharmacologic Suppression of Reperfusion Injury Following Endovascular Thrombectomy In Stroke awarded by (Principal Investigator). 2019 to 2020
Translating Endogenous Vascular Protective Cascades into Therapy for Aneurysmal Subarachnoid Hemorrhage awarded by Washington University in St. Louis (Principal Investigator). 2015 to 2020
Effect of Aging on Brain Ischemia/Stroke Outcome; Pathways, Mechanisms, and Rescue awarded by National Institutes of Health (Significant Contributor). 2016 to 2020
Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage awarded by National Institutes of Health (Principal Investigator). 2015 to 2018
The trajectory and significance of perioperative changes in AD biomarkers awarded by International Anesthesia Research Society (Significant Contributor). 2014 to 2018
STIM1-dependent calcium signaling in neuronal responses to hypoxia and ischemia awarded by National Institutes of Health (Collaborator). 2015 to 2017
Treatment of Neuropathic Pain after SCI with a Catalytic Oxidoreductant awarded by University of Alabama at Birmingham (Principal Investigator). 2013 to 2016
Li, Litao, et al. “Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5.” Antioxidants (Basel), vol. 9, no. 6, June 2020. Pubmed, doi:10.3390/antiox9060467. Full Text
Ma, Shuang, et al. “Argon Inhalation for 24 Hours After Onset of Permanent Focal Cerebral Ischemia in Rats Provides Neuroprotection and Improves Neurologic Outcome.” Crit Care Med, vol. 47, no. 8, Aug. 2019, pp. e693–99. Pubmed, doi:10.1097/CCM.0000000000003809. Full Text
Terrando, Niccolò, and David S. Warner. “Xenon for traumatic brain injury: a noble step forward and a wet blanket.” Br J Anaesth, vol. 123, no. 1, July 2019, pp. 9–11. Pubmed, doi:10.1016/j.bja.2019.04.004. Full Text
Klinger, Rebecca Y., et al. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology, vol. 130, no. 6, June 2019, pp. 958–70. Pubmed, doi:10.1097/ALN.0000000000002668. Full Text
Xie, Yongqiu, et al. “Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.” Transl Stroke Res, vol. 10, no. 2, Apr. 2019, pp. 231–39. Pubmed, doi:10.1007/s12975-018-0633-z. Full Text
Klinger, Rebecca Y., et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.” Anesthesiology, vol. 128, no. 4, Apr. 2018, pp. 728–44. Pubmed, doi:10.1097/ALN.0000000000002103. Full Text
Liu, Huaqin, et al. “Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.” Aging Dis, vol. 9, no. 1, Feb. 2018, pp. 31–39. Pubmed, doi:10.14336/AD.2017.0221. Full Text
Idris, Ahamed H., et al. “2015 revised Utstein-style recommended guidelines for uniform reporting of data from drowning-related resuscitation: An ILCOR advisory statement.” Resuscitation, vol. 118, Sept. 2017, pp. 147–58. Pubmed, doi:10.1016/j.resuscitation.2017.05.028. Full Text
Idris, Ahamed H., et al. “2015 Revised Utstein-Style Recommended Guidelines for Uniform Reporting of Data From Drowning-Related Resuscitation: An ILCOR Advisory Statement.” Circ Cardiovasc Qual Outcomes, vol. 10, no. 7, July 2017. Pubmed, doi:10.1161/HCQ.0000000000000024. Full Text
Ma, Shuang, et al. “24 HOUR POST-TREATMENT WITH THE NOBLE GAS ARGON PROVIDES ROBUST NEUROPROTECTION AND IMPROVEMENT IN NEUROLOGIC OUTCOME AFTER FOCAL CEREBRAL ISCHEMIA IN RATS.” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 312–312.
Sheng, H., et al. “Xenon as a therapy in experimental intracerebral hemorrhage.” Journal of Cerebral Blood Flow and Metabolism, vol. 37, SAGE PUBLICATIONS INC, 2017, pp. 451–451.
Lei, Beilei, et al. “Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.” Neuroendocrinology, vol. 103, no. 6, 2016, pp. 665–77. Pubmed, doi:10.1159/000442204. Full Text
Weitner, Tin, et al. “Comprehensive Pharmacokinetic Studies and Biodistribution of Two Cationic Mn Porphyrin-Based Catalysts, MnTE-2-PyP5+ and MnTnHex-2-PyP5+: Plasma and Organ Oral Availability, Mitochondrial, Cytosolic, Whole Brain, Hippocampus and Cortex Distribution.” Free Radical Biology and Medicine, vol. 53, Elsevier BV, 2012, pp. S118–S118. Crossref, doi:10.1016/j.freeradbiomed.2012.10.291. Full Text
Rajic, Zrinka, et al. “A Breakthrough in the Development of SOD Mimics/Cellular Redox Modulators: a Superior Mn porphyrin, MnTnBuOE-2-PyP5+ With Finely Tuned Properties.” Free Radical Biology and Medicine, vol. 51, Elsevier BV, 2011, pp. S95–S95. Crossref, doi:10.1016/j.freeradbiomed.2011.10.462. Full Text
Tovmasyan, Artak, et al. “Structural Modification Diminishes Toxicity of Lipophilic Longer Mn(III) N-alkylpyridyl porphyrin-based Powerful SOD Mimics: Synthesis, Characterization and SOD-deficient E. coli and S. cerevisiae studies.” Free Radical Biology and Medicine, vol. 49, Elsevier BV, 2010, pp. S201–S201. Crossref, doi:10.1016/j.freeradbiomed.2010.10.583. Full Text
Kos, Ivan, et al. “Oral Availability of Mnte-2-Pyp(5+), a Potent Antioxidant and Cellular Redox Modulator.” Free Radical Biology and Medicine, vol. 45, ELSEVIER SCIENCE INC, 2008, pp. S86–87.
McAdoo, J. D., et al. “Apolipoprotein E-mimetic peptide reduces brain injury in a neonatal hypoxia-ischemia model.” Pediatric Research, vol. 55, no. 4, INT PEDIATRIC RESEARCH FOUNDATION, INC, 2004, pp. 408A-408A.
Lynch, J. R., et al. “An ApoE-based therapeutic improves outcome and reduces Alzheimer's disease pathology after head injury.” Annals of Neurology, vol. 56, WILEY-LISS, 2004, pp. S42–S42.
Warner, D. S., et al. “Ec-SOD overexpression reduces blood-spinal cord barrier permeability and inflammatory cell infiltration, but does not improve outcome from spinal cord compression injury in the mouse.” Free Radical Biology and Medicine, vol. 37, PERGAMON-ELSEVIER SCIENCE LTD, 2004, pp. S165–S165.
Mackensen, G. B., et al. “Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.” Br J Anaesth, vol. 91, no. 5, Nov. 2003, pp. 656–61. Pubmed, doi:10.1093/bja/aeg234. Full Text
Swaminathan, Madhav, et al. “Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.” Anesth Analg, vol. 95, no. 1, July 2002, pp. 1–8. Pubmed, doi:10.1097/00000539-200207000-00001. Full Text
Grigore, Alina M., et al. “The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.” Anesth Analg, vol. 94, no. 1, Jan. 2002, pp. 4–10. Pubmed, doi:10.1097/00000539-200201000-00002. Full Text