David Samuel Warner

David Samuel Warner

Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine

External Address: 
303 Research Dr., 134 Sands Buildign, Durham, NC 27710
Internal Office Address: 
Box 3094 Med Ctr, Durham, NC 27710
Phone: 
919.684.6633

Overview

Humans may sustain a variety of forms of acute central nervous system injury including ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection Laboratories is dedicated to examining the pathophysiology of acute brain and spinal cord injury with particular reference to disease states managed in the perioperative or neurointensive care environments. Rodent recovery models of cerebral ischemia, traumatic brain injury, cardiopulmonary bypass, subarachnoid hemorrhage, spinal cord ischemia, and perinatal hypoxia have been established with requisite control of relevant physiologic variables. Experimental protocols examine the response of brain to these insults and seek to define appropriate therapeutic interventions. Our work examines the role reactive oxygen species in CNS injury with emphasis on how pharmacologic or genetic variants modulate these processes. Effects of altered synthesis of superoxide dismutase and apolipoprotein E are investigated in transgenic/knock out mice. Outcome studies allow definition of efficacy of pharmacologic agents including superoxide dismutase mimetics, PARP-1 inhibitors, hepatocyte growth factor mimetics, recombinant apolipoprotein E and its peptide fragments, SNO-hemoglobin, and anesthetics on histologic and behavioral recovery from ischemic/traumatic insults. Recent focus has been on SUMOylation responses of neural tissue to ischemic stress. Neurochemical, immunohistochemical, molecular biologic, genomic, and proteomic techniques are used to define the mechanistic basis of observations made in outcome studies. Primary neuronal/glial cultures, organotypic hippocampal slices and immortalized transfected human cell lines are used investigate mechanistic interactions between pharmacologic agents and metabolic stresses.

Education & Training

  • M.D., University of Wisconsin - Madison 1980

Sheng, Huaxin, et al. “Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.Free Radic Biol Med, vol. 47, no. 7, Oct. 2009, pp. 917–23. Pubmed, doi:10.1016/j.freeradbiomed.2009.05.039. Full Text

Takata, Ken, et al. “Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.J Neurosurg Anesthesiol, vol. 21, no. 4, Oct. 2009, pp. 326–33. Pubmed, doi:10.1097/ANA.0b013e3181acfde7. Full Text

Wise-Faberowski, Lisa, et al. “Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition.Anesth Analg, vol. 109, no. 1, July 2009, pp. 205–10. Pubmed, doi:10.1213/ane.0b013e3181a27e37. Full Text

Warner, David S., et al. “Drowning: a cry for help.Anesthesiology, vol. 110, no. 6, June 2009, pp. 1211–13. Pubmed, doi:10.1097/ALN.0b013e3181a4c3d3. Full Text

Todd, Michael M., et al. “Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage.Neurosurgery, vol. 64, no. 5, May 2009, pp. 897–908. Pubmed, doi:10.1227/01.NEU.0000341903.11527.2F. Full Text

Wise-Faberowski, Lisa, et al. “Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.Free Radic Res, vol. 43, no. 4, Apr. 2009, pp. 329–39. Pubmed, doi:10.1080/10715760902736283. Full Text

Mackensen, G. Burkhard, et al. “Perioperative hypothermia: use and therapeutic implications.J Neurotrauma, vol. 26, no. 3, Mar. 2009, pp. 342–58. Pubmed, doi:10.1089/neu.2008.0596. Full Text

Pasternak, Jeffrey J., et al. “Effect of nitrous oxide use on long-term neurologic and neuropsychological outcome in patients who received temporary proximal artery occlusion during cerebral aneurysm clipping surgery.Anesthesiology, vol. 110, no. 3, Mar. 2009, pp. 563–73. Pubmed, doi:10.1097/ALN.0b013e318197ff81. Full Text

Warner, David S. “Filling in the blanks.Anesthesiology, vol. 110, no. 1, Jan. 2009, pp. 10–11. Pubmed, doi:10.1097/ALN.0b013e3181913ddc. Full Text

Eisenach, James C., et al. “2008 in review: advancing medicine in anesthesiology.Anesthesiology, vol. 109, no. 6, Dec. 2008, pp. 962–72. Pubmed, doi:10.1097/ALN.0b013e31818e4149. Full Text

Pages