David Samuel Warner

David Samuel Warner

Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine

External Address: 
303 Research Dr., 134 Sands Buildign, Durham, NC 27710
Internal Office Address: 
Box 3094 Med Ctr, Durham, NC 27710
Phone: 
919.684.6633

Overview

Humans may sustain a variety of forms of acute central nervous system injury including ischemia, trauma, vasospasm, and perinatal hypoxemia. The Multidisciplinary Neuroprotection Laboratories is dedicated to examining the pathophysiology of acute brain and spinal cord injury with particular reference to disease states managed in the perioperative or neurointensive care environments. Rodent recovery models of cerebral ischemia, traumatic brain injury, cardiopulmonary bypass, subarachnoid hemorrhage, spinal cord ischemia, and perinatal hypoxia have been established with requisite control of relevant physiologic variables. Experimental protocols examine the response of brain to these insults and seek to define appropriate therapeutic interventions. Our work examines the role reactive oxygen species in CNS injury with emphasis on how pharmacologic or genetic variants modulate these processes. Effects of altered synthesis of superoxide dismutase and apolipoprotein E are investigated in transgenic/knock out mice. Outcome studies allow definition of efficacy of pharmacologic agents including superoxide dismutase mimetics, PARP-1 inhibitors, hepatocyte growth factor mimetics, recombinant apolipoprotein E and its peptide fragments, SNO-hemoglobin, and anesthetics on histologic and behavioral recovery from ischemic/traumatic insults. Recent focus has been on SUMOylation responses of neural tissue to ischemic stress. Neurochemical, immunohistochemical, molecular biologic, genomic, and proteomic techniques are used to define the mechanistic basis of observations made in outcome studies. Primary neuronal/glial cultures, organotypic hippocampal slices and immortalized transfected human cell lines are used investigate mechanistic interactions between pharmacologic agents and metabolic stresses.

Education & Training

  • M.D., University of Wisconsin - Madison 1980

Elsersy, Hazem, et al. “Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection.Anesthesiology, vol. 105, no. 1, July 2006, pp. 81–90. Pubmed, doi:10.1097/00000542-200607000-00016. Full Text

McDonagh, David L., et al. “Induction of hypothermia after intraoperative hypoxic brain insult.Anesth Analg, vol. 103, no. 1, July 2006, pp. 180–81. Pubmed, doi:10.1213/01.ane.0000221436.92700.8e. Full Text

Warner, David S., and Daniel T. Laskowitz. “Changing outcome from aneurysmal subarachnoid hemorrhage: another step closer.Anesthesiology, vol. 104, no. 4, Apr. 2006, pp. 629–30. Pubmed, doi:10.1097/00000542-200604000-00002. Full Text

Freiberger, John J., et al. “A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats.Brain Res, vol. 1075, no. 1, Feb. 2006, pp. 213–22. Pubmed, doi:10.1016/j.brainres.2005.12.088. Full Text

Leinenweber, Stephen B., et al. “Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.Eur J Pharmacol, vol. 531, no. 1–3, Feb. 2006, pp. 126–32. Pubmed, doi:10.1016/j.ejphar.2005.12.031. Full Text

Hanks, R. Kyle, et al. “The effect of age on sciatic nerve block duration.Anesth Analg, vol. 102, no. 2, Feb. 2006, pp. 588–92. Pubmed, doi:10.1213/01.ane.0000189552.85175.db. Full Text

Faberowski, L. W., and D. S. Warner. “The effect of hypoxia on the developing brain: a function of age.” Journal of Neurosurgical Anesthesiology, vol. 18, no. 4, Jan. 2006, pp. 25–35.

Gao, Junling, et al. “A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.Neurocrit Care, vol. 4, no. 1, 2006, pp. 25–31. Pubmed, doi:10.1385/NCC:4:1:025. Full Text

Wang, Haichen, et al. “Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.Neurocrit Care, vol. 5, no. 1, 2006, pp. 71–78. Pubmed, doi:10.1385/NCC:5:1:71. Full Text

Takata, K., et al. “A rat model of cerebral vasospasm resulting in chronic motor and neurocognitive deficits following experimental sah.” Journal of Neurosurgical Anesthesiology, vol. 18, no. 4, Jan. 2006, p. 295. Scopus, doi:10.1097/00008506-200610000-00059. Full Text

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