James Michael Provenzale

James Michael Provenzale

Professor of Radiology

External Address: 
1533 Hosp North, Durham, NC 27710
Internal Office Address: 
Box 3808 Med Ctr, Durham, NC 27710
Phone: 
919.684.7218

Overview

I have the following major research areas:
I. Diffusion tensor imaging (an MR technique that measures rate and direction of microscopic water motion) to examine white matter pathways in the brain. This technique is used by many investigators in an attempt to understand white matter microstructure. My recent work has centered on the histological correlation of DTI metrics. In addition, because DTI metrics can vary substantially within a single scanner at multiple time points as well as between scanners, my work is focused on understanding causes of such variability and designing methods to decrease it. 
Since 1998, I have mentored third-year students at Duke University School of Medicine (typically one medical student per year) in both DTI research and perfusion imaging research. Although the research techniques are highly advanced, our implementation of various "user-friendly" software programs allows students with little or no prior experience to analyze data in a productive manner. Our research is also well-suited to individuals with advanced computer skills or an interest in biomedical or electrical engineering. Students work closely with research personnel on a daily basis. They also meet with collaborators from various basic science and clinical departments and me in a laboratory meeting once a week. The focus of these meetings is to plan experiments, refine research methods, discuss experimental results and prepare manuscripts. Students serve as first authors or co-authors on manuscripts based on their specific research project. The results of a number of such projects have been published.

II. Applications of nanotechnology to treatment of cancer (both CNS and non-CNS) and brain disorders. My research involves design and implementation of nanoparticles and fluorescent molecules for cancer diagnosis and therapy. Although I am trained as a neurologist and neuroradiologist, most of my nanotechnology-based research is oriented towards non-CNS tumors such as breast cancer and sarcomas. In the past few years, my Emory and Georgia Tech colleagues and I have conducted research using animals with naturally-occurring tumors at the University of Georgia College of Veterinary Medicine. This work has focused on the use of a handheld device to detect fluorophores that are administered intravenously prior to surgery. We are presently validating the use of this combination of imaging device and contrast agent to guide surgical resection of tumors. I am also interested in development of nanotechnology-based non-invasive and minimally invasive devices that can continuously monitor tumor physiological characteristics and response to therapy. This work is done in conjunction with a number of colleagues in Biomedical Engineering at both Duke and Emory and supported by a number of NIH grants. Finally, I have a strong interest in use of nanotechnology for tissue engineering and regenerative medicine. 

Education & Training

  • M.D., Albany Medical College 1983

Selected Grants

Comparison of Power Injection vs Hand Injection of Contrast Media in MR Perfusion awarded by Bayer Healthcare Pharmaceuticals Inc (Principal Investigator). 2014 to 2018

Measurements of Reproducibility of DTI Metrics on Clinical MR scanners using a DTI Phantom awarded by Radiological Society of North America (Principal Investigator). 2016 to 2018

Research Training In Neuro-Oncology awarded by National Institutes of Health (Mentor). 1998 to 2016

Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health (Co-Mentor). 2007 to 2013

High Resolution Diffusion-Weighted Magnetic Resonance Imaging at 300-Micron Level awarded by National Institutes of Health (Advisor). 2006 to 2012

Genetic Contributions to Alterations in Brain Structure and Function in Depression awarded by National Institutes of Health (Neuro-radiologist). 2008 to 2012

Prevention of Cardiovascular Complications of Pediatric SLE awarded by National Institutes of Health (Co Investigator). 2002 to 2011

Vascular Depression: Longitudinal Changes awarded by National Institutes of Health (Investigator). 2007 to 2011

Bipolar Disorder in Late Life awarded by National Institutes of Health (Co Investigator). 2005 to 2010

Research Training In Neuro-Oncology awarded by National Institutes of Health (Mentor). 2005 to 2010

Pages

Nelson, R. C., et al. Preface. 2012.

Nelson, R. C., et al. Preface. 2012.

Provenzale, J. M. “Neuroradiology: Case 30.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 374–77.

Provenzale, J. M. “Neuroradiology: Case 29.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 372–73.

Provenzale, J. M. “Neuroradiology: Case 17.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 342–46.

Provenzale, J. M. “Neuroradiology: Case 28.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 370–71.

Cornett, J. B., and J. M. Provenzale. “Neuroradiology: Case 7.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 310–11.

Provenzale, J. M., and E. R. Heinz. “Neuroradiology: Case 12.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 328–31.

Provenzale, J. M. “Neuroradiology: Case 25.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 364–65.

Provenzale, J. M. “Neuroradiology: Case 27.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 368–69.

Provenzale, J. M. “Neuroradiology: Case 20.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 352–53.

Provenzale, J. M., and D. S. Enterline. “Neuroradiology: Case 19.” Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012, pp. 350–52.

Pages

Provenzale, James M., et al. “Peering Into Peer Review: AJR Neuroradiology Reviewers Discuss Their Approaches to Assessing a Manuscript.Ajr Am J Roentgenol, vol. 214, no. 1, Jan. 2020, pp. 45–49. Pubmed, doi:10.2214/AJR.19.21999. Full Text

Provenzale, James M. “Lessons Learned From AJR Neuroradiology Manuscript Reviews: Informative Advice for Prospective Authors in All Fields of Radiology.Ajr Am J Roentgenol, vol. 214, no. 1, Jan. 2020, pp. 41–44. Pubmed, doi:10.2214/AJR.19.21841. Full Text

Provenzale, James M. “A Shorter Invitation Period for AJR Manuscript Reviewers: Impact on Time to Completion of Reviews.Ajr Am J Roentgenol, vol. 214, no. 1, Jan. 2020, pp. 37–40. Pubmed, doi:10.2214/AJR.19.21358. Full Text

Tranvinh, Eric, et al. “Imaging Evaluation of the Adult Presenting With New-Onset Seizure.Ajr Am J Roentgenol, vol. 212, no. 1, Jan. 2019, pp. 15–25. Pubmed, doi:10.2214/AJR.18.20202. Full Text

Provenzale, James M., et al. “Analysis of variability of fractional anisotropy values at 3T using a novel diffusion tensor imaging phantom.Neuroradiol J, vol. 31, no. 6, Dec. 2018, pp. 581–86. Pubmed, doi:10.1177/1971400918789383. Full Text

Parikh, Asit, et al. “A Programme for Risk Assessment and Minimisation of Progressive Multifocal Leukoencephalopathy Developed for Vedolizumab Clinical Trials.Drug Saf, vol. 41, no. 8, Aug. 2018, pp. 807–16. Pubmed, doi:10.1007/s40264-018-0669-8. Full Text

Li, Jonathan Y., et al. “Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.Neuroradiol J, vol. 31, no. 2, Apr. 2018, pp. 168–76. Pubmed, doi:10.1177/1971400917733431. Full Text

Middleton, Dana M., et al. “Diffusion tensor imaging findings suggestive of white matter alterations in a canine model of mucopolysaccharidosis type I.Neuroradiol J, vol. 31, no. 1, Feb. 2018, pp. 90–94. Pubmed, doi:10.1177/1971400917715792. Full Text

Abrigo, Jill M., et al. “Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation.Cochrane Database Syst Rev, vol. 1, Jan. 2018, p. CD011551. Pubmed, doi:10.1002/14651858.CD011551.pub2. Full Text

Wilde, Elisabeth A., et al. “Assessment of quantitative magnetic resonance imaging metrics in the brain through the use of a novel phantom.Brain Inj, vol. 32, no. 10, 2018, pp. 1266–76. Pubmed, doi:10.1080/02699052.2018.1494855. Full Text

Pages

Lee, V. S., et al. “Post-traumatic epidermoid cyst: CT appearance.J Comput Assist Tomogr, vol. 19, no. 1, Jan. 1995, pp. 153–55. Pubmed, doi:10.1097/00004728-199501000-00032. Full Text