Jeffrey Nicholas Browndyke
Associate Professor of Psychiatry and Behavioral Sciences
Overview
Dr. Browndyke is an Associate Professor of Behavioral Health & Neurosciences in the Department of Psychiatry & Behavioral Sciences. He has a secondary appointment as Assistant Professor of Cardiovascular & Thoracic Surgery.
Dr. Browndyke's research interests involve the use of advanced neurocognitive and neuroimaging techniques for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes. His research also involves novel telehealth methods for remote neurocognitive evaluation and implementation of non-invasive neuromodulatory techniques to assist in postoperative recovery and dementia risk reduction.
Dr. Browndyke's clinical expertise is focused upon geriatric neuropsychology with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders in adults and US veteran patient populations.
Selected Grants
Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF) awarded by National Institutes of Health (Co Investigator). 2021 to 2026
Bertrand, Philippe B., et al. “Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation.” J Am Coll Cardiol, vol. 77, no. 6, Feb. 2021, pp. 713–24. Pubmed, doi:10.1016/j.jacc.2020.11.066. Full Text Open Access Copy
Terrando, Niccolò, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep, vol. 11, no. 1, Feb. 2021, p. 3047. Pubmed, doi:10.1038/s41598-021-82606-5. Full Text
Berger, Miles, et al. “APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.” J Alzheimers Dis, vol. 79, no. 2, 2021, pp. 511–30. Pubmed, doi:10.3233/JAD-200747. Full Text
VanDusen, Keith W., et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis, vol. 80, no. 3, 2021, pp. 1281–97. Pubmed, doi:10.3233/JAD-201544. Full Text Open Access Copy
Oyeyemi, Deborah M., et al. “Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.” J Geriatr Psychiatry Neurol, Dec. 2020, p. 891988720978791. Pubmed, doi:10.1177/0891988720978791. Full Text
Nobuhara, Chloe K., et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol, vol. 267, no. 7, July 2020, pp. 2002–06. Pubmed, doi:10.1007/s00415-020-09797-1. Full Text
Ferket, Bart S., et al. “Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation.” J Thorac Cardiovasc Surg, vol. 159, no. 6, June 2020, pp. 2230-2240.e15. Pubmed, doi:10.1016/j.jtcvs.2019.06.040. Full Text
Lala, Anuradha, et al. “Risk for non-home discharge following surgery for ischemic mitral valve disease.” J Thorac Cardiovasc Surg, Mar. 2020. Pubmed, doi:10.1016/j.jtcvs.2020.02.084. Full Text
Blumenthal, James A., et al. “Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.” J Am Geriatr Soc, vol. 68, no. 3, Mar. 2020, pp. 559–68. Pubmed, doi:10.1111/jgs.16252. Full Text
Smith, Patrick J., et al. “Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.” J Alzheimers Dis, vol. 77, no. 4, 2020, pp. 1793–803. Pubmed, doi:10.3233/JAD-200374. Full Text
Pages
Polascik, Bryce, et al. “COGNITIVE CONSEQUENCES OF COVID-19 IN OLDER ADULTS WITH COGNITIVE IMPAIRMENT.” American Journal of Geriatric Psychiatry, vol. 29, no. 4, 2021, pp. S75–76.
Devinney, Michael, et al. “The SANDMAN Study: Sleep Apnea, Neuroinflammation, and Cognitive Dysfunction Manifesting After Non-cardiac surgery.” Anesthesia and Analgesia, vol. 130, 2020, pp. 514–15.
Ha, Christine, et al. “Cognitive and Cerebrospinal fluid Alzheimer's Disease biomarker changes over time in older surgical patients and matched nonsurgical controls.” Anesthesia and Analgesia, vol. 130, 2020, pp. 502–502.
Devinney, Michael, et al. “THE SANDMAN STUDY: SLEEP APNEA, NEUROINFLAMMATION, AND COGNITIVE DYSFUNCTION MANIFESTING AFTER NON-CARDIAC SURGERY.” Anesthesia and Analgesia, vol. 128, 2019, pp. 918–918.
Bunning, Thomas, et al. “THE INTUIT STUDY: INVESTIGATING NEUROINFLAMMATION UNDERLYING POSTOPERATIVE NEUROCOGNITIVE DYSFUNCTION AND DELIRIUM IN OLDER ADULTS.” Anesthesia and Analgesia, vol. 128, 2019, pp. 432–432.
Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.
Heflin, M., et al. “POSH-DREAM: Mobile Point-of-Contact Delirium Risk Assessment & Identification.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S136–S136.
Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.
Khan, Babar A., et al. “DECONSTRUCTING DELIRIUM: RETHINKING THE ROLE OF BIOMARKERS AND DIAGNOSTIC ANOMALIES.” The American Journal of Geriatric Psychiatry, vol. 27, no. 3, Elsevier BV, 2019, pp. S38–39. Crossref, doi:10.1016/j.jagp.2019.01.188. Full Text
Berger, M., et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S5–S5.