Jeffrey Nicholas Browndyke
Associate Professor of Psychiatry and Behavioral Sciences
Overview
Dr. Browndyke is an Associate Professor of Geriatric Behavioral Health in the Department of Psychiatry & Behavioral Sciences. He also holds affiliate faculty appointments with the Duke Brain Imaging & Analysis Center (BIAC), Duke Institute for Brain Science (DIBS), Center for Cognitive Neuroscience (CCN), and the Duke Center for Geriatric Surgery. He has dual appointment to the Duke University Medical Center and the Durham VA Medical Center, the latter of which is where his clinical work is currently conducted.
Dr. Browndyke's research interests include the development and use of functional and structural neuroimaging biomarkers for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes. His research also involves the differential expression of cognitive and behavioral characteristics of late-life postoperative cognitive dysfunction and delirium and their association with later dementia risk.
Dr. Browndyke's clinical expertise is focused upon adult and geriatric populations with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders, as well as forensic/medicolegal evaluation of adults and US veteran patient populations.
Selected Grants
Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Collaborator). 2017 to 2022
A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer’s Drug Discovery Foundation (Co Investigator). 2018 to 2021
Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health (Co Investigator). 2016 to 2021
The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research (Analyst). 2019 to 2021
Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension awarded by National Institutes of Health (Co Investigator). 2014 to 2020
Assessing Large-scale Brain Connectivities in Mild Cognitive Impairment awarded by University of Georgia (Principal Investigator). 2013 to 2020
Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine-Consortium Agreement awarded by Mount Sinai School of Medicine (Co Investigator). 2013 to 2020
The Significance of Perioperative Changes in CSF tau levels in the Elderly awarded by National Institutes of Health (Mentor). 2015 to 2018
Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health (Co Investigator). 2011 to 2018
The trajectory and significance of perioperative changes in AD biomarkers awarded by International Anesthesia Research Society (Significant Contributor). 2014 to 2018
Pages
Nobuhara, Chloe K., et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol, vol. 267, no. 7, July 2020, pp. 2002–06. Pubmed, doi:10.1007/s00415-020-09797-1. Full Text
Ferket, Bart S., et al. “Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation.” J Thorac Cardiovasc Surg, vol. 159, no. 6, June 2020, pp. 2230-2240.e15. Pubmed, doi:10.1016/j.jtcvs.2019.06.040. Full Text
Lala, Anuradha, et al. “Risk for non-home discharge following surgery for ischemic mitral valve disease.” J Thorac Cardiovasc Surg, Mar. 2020. Pubmed, doi:10.1016/j.jtcvs.2020.02.084. Full Text
Blumenthal, James A., et al. “Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.” J Am Geriatr Soc, vol. 68, no. 3, Mar. 2020, pp. 559–68. Pubmed, doi:10.1111/jgs.16252. Full Text
VanDusen, Keith W., et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis, vol. 75, no. 4, 2020, pp. 1319–28. Pubmed, doi:10.3233/JAD-191185. Full Text
Madden, David J., et al. “Neural activation for actual and imagined movement following unilateral hand transplantation: a case study.” Neurocase, vol. 25, no. 6, Dec. 2019, pp. 225–34. Pubmed, doi:10.1080/13554794.2019.1667398. Full Text Open Access Copy
Mahanna-Gabrielli, Elizabeth, et al. “Corrigendum to 'State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018' (Br J Anaesth 2019; 123: 464-478).” Br J Anaesth, vol. 123, no. 6, Dec. 2019, p. 917. Pubmed, doi:10.1016/j.bja.2019.09.014. Full Text
Berger, Miles, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg, vol. 129, no. 5, Nov. 2019, pp. e150–54. Pubmed, doi:10.1213/ANE.0000000000004179. Full Text Open Access Copy
Mahanna-Gabrielli, Elizabeth, et al. “State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018.” Br J Anaesth, vol. 123, no. 4, Oct. 2019, pp. 464–78. Pubmed, doi:10.1016/j.bja.2019.07.004. Full Text Open Access Copy
Browndyke, Jeffrey N., et al. “The Devil Is in the Details: Comparison of Postoperative Delirium and Neurocognitive Dysfunction.” Anesthesiology, vol. 131, no. 3, Sept. 2019, pp. 456–58. Pubmed, doi:10.1097/ALN.0000000000002823. Full Text Open Access Copy
Pages
Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.
Heflin, M., et al. “POSH-DREAM: Mobile Point-of-Contact Delirium Risk Assessment & Identification.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S136–S136.
Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.
Khan, Babar A., et al. “DECONSTRUCTING DELIRIUM: RETHINKING THE ROLE OF BIOMARKERS AND DIAGNOSTIC ANOMALIES.” The American Journal of Geriatric Psychiatry, vol. 27, no. 3, Elsevier BV, 2019, pp. S38–39. Crossref, doi:10.1016/j.jagp.2019.01.188. Full Text
Berger, M., et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S5–S5.
Piccini, Jonathan P., et al. “Neurocognitive Function in Atrial Fibrillation: Catheter Ablation versus Medical Management.” Circulation, vol. 136, LIPPINCOTT WILLIAMS & WILKINS, 2017.
Browndyke, Jeffrey N., et al. “COMING TOGETHER TO FIGHT DELIRIUM: HOW TO DELIVER TEAM-BASED, INTERDISCIPLINARY CARE TO PREVENT, DETECT, AND MANAGE DELIRIUM AND ITS LONG-TERM SEQUELAE.” American Journal of Geriatric Psychiatry, vol. 25, no. 3, ELSEVIER SCIENCE INC, 2017, pp. S25–26.
Wang, Sophia, et al. “Delirium and Post-Operative Cognitive Decline: Who is at Risk for the Long-Term Neurocognitive and Neuropsychiatric Effects?” The American Journal of Geriatric Psychiatry, vol. 24, no. 3, Elsevier BV, 2016, pp. S27–S27. Crossref, doi:10.1016/j.jagp.2016.01.039. Full Text
Kamholz, Barbara, et al. “Frailty, Delirium, and Postoperative Cognitive Decline: What Are the Long-Term Effects of Acute Late-Life Medical and Surgical Events?” The American Journal of Geriatric Psychiatry, vol. 23, no. 3, Elsevier BV, 2015, pp. S5–6. Crossref, doi:10.1016/j.jagp.2014.12.009. Full Text
Foster, Chris, et al. “PREFRONTAL CONTRIBUTIONS TO RELATIONAL ENCODING IN HEALTHY AGING AND MILD COGNITIVE IMPAIRMENT.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 197–197. Open Access Copy