Jeffrey Nicholas Browndyke
Associate Professor of Psychiatry and Behavioral Sciences
Overview
Dr. Browndyke is an Associate Professor of Behavioral Health & Neurosciences in the Department of Psychiatry & Behavioral Sciences. He has a secondary appointment as Assistant Professor of Cardiovascular & Thoracic Surgery.
Dr. Browndyke's research interests involve the use of advanced neurocognitive and neuroimaging techniques for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes. His research also involves novel telehealth methods for remote neurocognitive evaluation and implementation of non-invasive neuromodulatory techniques to assist in postoperative recovery and dementia risk reduction.
Dr. Browndyke's clinical expertise is focused upon geriatric neuropsychology with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders in adults and US veteran patient populations.
Selected Grants
Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF) awarded by National Institutes of Health (Co Investigator). 2021 to 2026
Messé, Steven R., et al. “The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement.” J Thorac Cardiovasc Surg, Mar. 2022. Pubmed, doi:10.1016/j.jtcvs.2022.01.053. Full Text
Berger, Miles, et al. “Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.” Ann Clin Transl Neurol, vol. 9, no. 2, Feb. 2022, pp. 155–70. Pubmed, doi:10.1002/acn3.51499. Full Text
Oyeyemi, Deborah M., et al. “Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.” J Geriatr Psychiatry Neurol, vol. 35, no. 1, Jan. 2022, pp. 145–54. Pubmed, doi:10.1177/0891988720978791. Full Text
Lala, Anuradha, et al. “Risk for non-home discharge following surgery for ischemic mitral valve disease.” J Thorac Cardiovasc Surg, vol. 162, no. 6, Dec. 2021, pp. 1769-1778.e7. Pubmed, doi:10.1016/j.jtcvs.2020.02.084. Full Text
Browndyke, Jeffrey N., et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth, vol. 127, no. 6, Dec. 2021, pp. 917–28. Pubmed, doi:10.1016/j.bja.2021.08.012. Full Text Open Access Copy
Bertrand, Philippe B., et al. “Progression of Tricuspid Regurgitation After Surgery for Ischemic Mitral Regurgitation.” J Am Coll Cardiol, vol. 77, no. 6, Feb. 2021, pp. 713–24. Pubmed, doi:10.1016/j.jacc.2020.11.066. Full Text Open Access Copy
Terrando, Niccolò, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep, vol. 11, no. 1, Feb. 2021, p. 3047. Pubmed, doi:10.1038/s41598-021-82606-5. Full Text Open Access Copy
Berger, Miles, et al. “APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.” J Alzheimers Dis, vol. 79, no. 2, 2021, pp. 511–30. Pubmed, doi:10.3233/JAD-200747. Full Text
VanDusen, Keith W., et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis, vol. 80, no. 3, 2021, pp. 1281–97. Pubmed, doi:10.3233/JAD-201544. Full Text Open Access Copy
Nobuhara, Chloe K., et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol, vol. 267, no. 7, July 2020, pp. 2002–06. Pubmed, doi:10.1007/s00415-020-09797-1. Full Text
Pages
Yang, Rosa O., et al. “Perioperative neurocognitive and neuroimaging trajectories in older APOE4 carriers vs non-carriers: A prospective cohort study.” Anesthesia and Analgesia, vol. 132, no. 5S_SUPPL, 2021, pp. 545–46.
Polascik, Bryce, et al. “COGNITIVE CONSEQUENCES OF COVID-19 IN OLDER ADULTS WITH COGNITIVE IMPAIRMENT.” American Journal of Geriatric Psychiatry, vol. 29, no. 4, 2021, pp. S75–76.
Devinney, Michael, et al. “The SANDMAN Study: Sleep Apnea, Neuroinflammation, and Cognitive Dysfunction Manifesting After Non-cardiac surgery.” Anesthesia and Analgesia, vol. 130, 2020, pp. 514–15.
Ha, Christine, et al. “Cognitive and Cerebrospinal fluid Alzheimer's Disease biomarker changes over time in older surgical patients and matched nonsurgical controls.” Anesthesia and Analgesia, vol. 130, 2020, pp. 502–502.
Devinney, Michael, et al. “THE SANDMAN STUDY: SLEEP APNEA, NEUROINFLAMMATION, AND COGNITIVE DYSFUNCTION MANIFESTING AFTER NON-CARDIAC SURGERY.” Anesthesia and Analgesia, vol. 128, 2019, pp. 918–918.
Bunning, Thomas, et al. “THE INTUIT STUDY: INVESTIGATING NEUROINFLAMMATION UNDERLYING POSTOPERATIVE NEUROCOGNITIVE DYSFUNCTION AND DELIRIUM IN OLDER ADULTS.” Anesthesia and Analgesia, vol. 128, 2019, pp. 432–432.
Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.
Heflin, M., et al. “POSH-DREAM: Mobile Point-of-Contact Delirium Risk Assessment & Identification.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S136–S136.
Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.
Khan, Babar A., et al. “DECONSTRUCTING DELIRIUM: RETHINKING THE ROLE OF BIOMARKERS AND DIAGNOSTIC ANOMALIES.” The American Journal of Geriatric Psychiatry, vol. 27, no. 3, Elsevier BV, 2019, pp. S38–39. Crossref, doi:10.1016/j.jagp.2019.01.188. Full Text