Jeffrey Nicholas Browndyke

Jeffrey Nicholas Browndyke

Associate Professor in Psychiatry and Behavioral Sciences

External Address: 
Durham VAMC - Psychology Servi, 508 Fulton Street, Durham, NC 27705
Internal Office Address: 
Box 3503 Med Ctr, Durham, NC 27710


Dr. Browndyke is an Associate Professor of Geriatric Behavioral Health in the Department of Psychiatry & Behavioral Sciences.  He also holds affiliate faculty appointments with the Duke Brain Imaging & Analysis Center (BIAC), Duke Institute for Brain Science (DIBS), Center for Cognitive Neuroscience (CCN), and the Duke Center for Geriatric Surgery.  He has dual appointment to the Duke University Medical Center and the Durham VA Medical Center, the latter of which is where his clinical work is currently conducted. 

Dr. Browndyke's research interests include the development and use of functional and structural neuroimaging biomarkers for perioperative contributions to delirium and later dementia risk, monitoring of late-life neuropathological disease progression, and intervention/treatment outcomes.  His research also involves the differential expression of cognitive and behavioral characteristics of late-life postoperative cognitive dysfunction and delirium and their association with later dementia risk.

Dr. Browndyke's clinical expertise is focused upon adult and geriatric populations with an emphasis in the assessment, diagnosis, and treatment of dementia and related disorders, as well as forensic/medicolegal evaluation of adults and US veteran patient populations.

Education & Training

  • Ph.D., Louisiana State University at Baton Rouge 2001

  • B.S., University of Memphis 1993

Selected Grants

Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Collaborator). 2017 to 2022

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Assessing Large-scale Brain Connectivities in Mild Cognitive Impairment awarded by University of Georgia (Principal Investigator). 2013 to 2020

The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research (Analyst). 2019

Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension awarded by National Institutes of Health (Co Investigator). 2014 to 2019

Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine-Consortium Agreement awarded by Mount Sinai School of Medicine (Co Investigator). 2013 to 2019

The Significance of Perioperative Changes in CSF tau levels in the Elderly awarded by National Institutes of Health (Mentor). 2015 to 2018

Lifestyle, CVD Risk and Cognitive Impairment awarded by National Institutes of Health (Co Investigator). 2011 to 2018

The trajectory and significance of perioperative changes in AD biomarkers awarded by International Anesthesia Research Society (Significant Contributor). 2014 to 2018


Mahanna-Gabrielli, Elizabeth, et al. “State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018..” Br J Anaesth, vol. 123, no. 4, Oct. 2019, pp. 464–78. Pubmed, doi:10.1016/j.bja.2019.07.004. Full Text Open Access Copy

Madden, David J., et al. “Neural activation for actual and imagined movement following unilateral hand transplantation: a case study..” Neurocase, Sept. 2019, pp. 1–10. Pubmed, doi:10.1080/13554794.2019.1667398. Full Text Open Access Copy

Browndyke, Jeffrey N., et al. “The Devil Is in the Details: Comparison of Postoperative Delirium and Neurocognitive Dysfunction..” Anesthesiology, vol. 131, no. 3, Sept. 2019, pp. 456–58. Pubmed, doi:10.1097/ALN.0000000000002823. Full Text Open Access Copy

Klinger, Rebecca Y., et al. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial..” Anesthesiology, vol. 130, no. 6, June 2019, pp. 958–70. Pubmed, doi:10.1097/ALN.0000000000002668. Full Text

Berger, Miles, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction..” J Am Geriatr Soc, vol. 67, no. 4, Apr. 2019, pp. 794–98. Pubmed, doi:10.1111/jgs.15770. Full Text Open Access Copy

Blumenthal, James A., et al. “Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial..” Neurology, vol. 92, no. 3, Jan. 2019, pp. e212–23. Pubmed, doi:10.1212/WNL.0000000000006784. Full Text

Smith, Patrick J., et al. “Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation..” Ann Thorac Surg, vol. 107, no. 1, Jan. 2019, pp. 112–18. Pubmed, doi:10.1016/j.athoracsur.2018.07.056. Full Text Open Access Copy

Evered, L., et al. “Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018..” Br J Anaesth, vol. 121, no. 5, Nov. 2018, pp. 1005–12. Pubmed, doi:10.1016/j.bja.2017.11.087. Full Text


Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.

Heflin, M., et al. “POSH-DREAM: Mobile Point-of-Contact Delirium Risk Assessment & Identification.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S136–S136.

Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.

Khan, Babar A., et al. “DECONSTRUCTING DELIRIUM: RETHINKING THE ROLE OF BIOMARKERS AND DIAGNOSTIC ANOMALIES.” The American Journal of Geriatric Psychiatry, vol. 27, no. 3, Elsevier BV, 2019, pp. S38–39. Crossref, doi:10.1016/j.jagp.2019.01.188. Full Text

Berger, M., et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S5–S5.

Piccini, Jonathan P., et al. “Neurocognitive Function in Atrial Fibrillation: Catheter Ablation versus Medical Management.” Circulation, vol. 136, LIPPINCOTT WILLIAMS & WILKINS, 2017.


Wang, Sophia, et al. “Delirium and Post-Operative Cognitive Decline: Who is at Risk for the Long-Term Neurocognitive and Neuropsychiatric Effects?.” The American Journal of Geriatric Psychiatry, vol. 24, no. 3, Elsevier BV, 2016, pp. S27–S27. Crossref, doi:10.1016/j.jagp.2016.01.039. Full Text

Kamholz, Barbara, et al. “Frailty, Delirium, and Postoperative Cognitive Decline: What Are the Long-Term Effects of Acute Late-Life Medical and Surgical Events?.” The American Journal of Geriatric Psychiatry, vol. 23, no. 3, Elsevier BV, 2015, pp. S5–6. Crossref, doi:10.1016/j.jagp.2014.12.009. Full Text

Foster, Chris, et al. “PREFRONTAL CONTRIBUTIONS TO RELATIONAL ENCODING IN HEALTHY AGING AND MILD COGNITIVE IMPAIRMENT.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 197–197. Open Access Copy