Assistant Professor in Anesthesiology
Katherine Martucci Ph.D. is a neuroscientist who specializes in human clinical research of chronic pain, reward and motivation behaviors, sensory and acute pain perception, and opioid use and addiction. Dr. Martucci serves as Director of the Human Affect and Pain Neuroscience Lab which uses a combination of neuroimaging techniques, including functional magnetic resonance imaging (fMRI) of the brain and cervical spinal cord, as well as sensory, behavioral and psychological tests to study acute and chronic pain in humans.
As part of the Center for Translational Pain Medicine (CTPM) at Duke, Dr. Martucci’s lab is in the Department of Anesthesiology and conducts research in collaboration with the Brain Imaging and Analysis Center (BIAC) and Duke Institute for Brain Sciences (DIBS).
Dr. Martucci earned her Ph.D. in Neurobiology and Anatomy at Wake Forest School of Medicine and continued her training in clinical research with a postdoctoral fellowship at Stanford University. While at Stanford Dr. Martucci obtained a prestigious NIH K99 “Pathway to Independence Award” and launched her research program in human neuroscience of pain, reward, opioids, and addiction. At the start of her scientific career at Duke, Dr. Martucci obtained a NIH R00 “Transition to Independence Award” to conduct the first longitudinal neuroimaging clinical research study of how opioid medications affect the central nervous system in individuals with fibromyalgia. Dr. Martucci is passionate about providing new scientific knowledge related to chronic pain and opioid use and how these factors together influence central nervous system function and symptoms in individuals with chronic pain.
Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Mentor). 1996 to 2026
Duke Pain Early-phase Research Clinical Center (PERC) awarded by National Institutes of Health (Collaborator). 2019 to 2024
A High-Performance 3T MRI for Brain Imaging awarded by National Institutes of Health (Minor User). 2021 to 2022
The Impact of Opioids on Chronic Pain: Clinical Research and Career Training in Spinal Cord fMRI and Brain Reward Systems awarded by National Institutes of Health (Principal Investigator). 2018 to 2021
Berger, Miles, et al. “Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.” Ann Clin Transl Neurol, vol. 9, no. 2, Feb. 2022, pp. 155–70. Pubmed, doi:10.1002/acn3.51499. Full Text
Browndyke, Jeffrey N., et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth, vol. 127, no. 6, Dec. 2021, pp. 917–28. Pubmed, doi:10.1016/j.bja.2021.08.012. Full Text Open Access Copy
Karshikoff, Bianka, et al. “Relationship Between Blood Cytokine Levels, Psychological Comorbidity, and Widespreadness of Pain in Chronic Pelvic Pain.” Front Psychiatry, vol. 12, 2021, p. 651083. Pubmed, doi:10.3389/fpsyt.2021.651083. Full Text
Martucci, Katherine T., et al. “Spinal Cord Resting State Activity in Individuals With Fibromyalgia Who Take Opioids.” Front Neurol, vol. 12, 2021, p. 694271. Pubmed, doi:10.3389/fneur.2021.694271. Full Text
Martucci, Katherine T., et al. “Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain.” Sci Rep, vol. 9, no. 1, July 2019, p. 9633. Pubmed, doi:10.1038/s41598-019-45961-y. Full Text
Mackey, Sean, et al. “Neuroimaging-based pain biomarkers: definitions, clinical and research applications, and evaluation frameworks to achieve personalized pain medicine.” Pain Rep, vol. 4, no. 4, July 2019, p. e762. Pubmed, doi:10.1097/PR9.0000000000000762. Full Text
Martucci, Katherine T., et al. “Altered Cervical Spinal Cord Resting-State Activity in Fibromyalgia.” Arthritis Rheumatol, vol. 71, no. 3, Mar. 2019, pp. 441–50. Pubmed, doi:10.1002/art.40746. Full Text
Clemens, J. Quentin, et al. “Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.” Nat Rev Urol, vol. 16, no. 3, Mar. 2019, pp. 187–200. Pubmed, doi:10.1038/s41585-018-0135-5. Full Text
Martucci, Katherine T., et al. “Altered prefrontal correlates of monetary anticipation and outcome in chronic pain.” Pain, vol. 159, no. 8, Aug. 2018, pp. 1494–507. Pubmed, doi:10.1097/j.pain.0000000000001232. Full Text
Martucci, Katherine T., and Sean C. Mackey. “Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation.” Anesthesiology, vol. 128, no. 6, June 2018, pp. 1241–54. Pubmed, doi:10.1097/ALN.0000000000002137. Full Text
Baker, Anne, et al. “Variable Voxel-based Morphometry Observations of Gray Matter Differences in Fibromyalgia: Individual Differences or Methodological Inconsistency?” Journal of Pain, vol. 23, no. 5, 2022, pp. 44–44.
Park, Su Hyoun, et al. “Evidence of Intact Corticostriatal and Altered Subcortical-striatal Resting-state Functional Connectivity in Chronic Pain.” Journal of Pain, vol. 23, no. 5, 2022, pp. 44–44.
Weber, Kenneth A., et al. “Resting State Functional Connectivity Machine Learning Classification of Chronic Back Pain.” Annals of Neurology, vol. 86, WILEY, 2019, pp. S266–S266.
Jarrahi, Behnaz, et al. “Cold Water Pressor Test Differentially Modulates Functional Network Connectivity in Fibromyalgia Patients Compared with Healthy Controls.” Annu Int Conf Ieee Eng Med Biol Soc, vol. 2018, 2018, pp. 578–82. Pubmed, doi:10.1109/EMBC.2018.8512350. Full Text
Jarrahi, Behnaz, et al. “Investigating the BOLD spectral power of the intrinsic connectivity networks in fibromyalgia patients: A resting-state fMRI study.” Annu Int Conf Ieee Eng Med Biol Soc, vol. 2017, 2017, pp. 497–500. Pubmed, doi:10.1109/EMBC.2017.8036870. Full Text
At the Intersection of Affect Regulation, Reward/Value Processes, and Placebo: Altered Human Psychological, Neurobiological, and Opioidergic Systems in Chronic Pain. American Pain Society 2018 Scientific Summit. American Pain Society. 2018