Lawrence Gregory Appelbaum
Adjunct Associate Professor in the Department of Psychiatry and Behavioral Sciences
Greg Appelbaum is an Associate Professor in the Department of Psychiatry and Behavioral Sciences in the Duke University School of Medicine. He is a member of the Brain Stimulation Division of Psychiatry, where he directs the Human Performance Optimization lab (Opti Lab) and the Brain Stimulation Research Center. Dr. Appelbaum core member of the Center for Cognitive Neuroscience, holds a secondary appointment in the Department of Psychology and Neuroscience, and is a member of the Duke Institute for Brain Sciences where he teaches and advises in the Neuroscience major.
Dr. Appelbaum's research interests primarily concern the brain mechanisms underlying visual cognition, how these capabilities differ among individuals, and how they can be improved through behavioral, neurofeedback, and neuromodulation interventions. Within the field of cognitive neuroscience, his research has addressed visual perception, sensorimotor function, executive function, decision-making, and learning/expertise. In this research, he has utilized a combination of behavioral psychophysics coupled with the neuroscience techniques of electroencephalography (EEG), transcranial magnetic stimulation (TMS), functional magnetic resonance imaging (fMRI), and functional near infrared spectroscopy (fNIRS).
A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation in patients with Subacute Thoracic Spinal Cord Injury to improve Pain and augment Rehabilitation awarded by National Institutes of Health (Investigator). 2020 to 2026
Using network-guided TMS to ameliorate memory deficits in early Alzheimer's disease awarded by National Institutes of Health (Co Investigator). 2020 to 2022
Identifying the Optimal Neural Target for Misophonia Interventions awarded by The REAM Foundation (Co Investigator). 2019 to 2022
Quiet TMS: A Low-Acoustic-Noise Transcranial Magnetic Stimulation System awarded by National Institutes of Health (Co Investigator). 2016 to 2022
A High-Performance 3T MRI for Brain Imaging awarded by National Institutes of Health (Major User). 2021 to 2022
Neurophysiology and Cognitive Neuroscience (8.4): Sensorimotor Function in Elite Soldiers and Athletes awarded by Department of Defense (Principal Investigator). 2015 to 2021
Impact of Timing, Targeting, and Brain State on rTMS of Human and Non-Human Primates awarded by National Institutes of Health (Co Investigator). 2017 to 2021
Transcranial magnetic stimulation with enhanced focality and depth (fdTMS) awarded by National Institutes of Health (Advisor). 2017 to 2021
Using fMRI-guided TMS to increase central executive function in older adults awarded by National Institutes of Health (Principal Investigator). 2015 to 2021
Accurate and reliable computational dosimetry and targeting for transcranial magnetic stimulation awarded by National Institutes of Health (Collaborator). 2019 to 2020
Beynel, L., et al. “Neurobiology and neuromodulation of emotion in PTSD.” Emotion in Posttraumatic Stress Disorder: Etiology, Assessment, Neurobiology, and Treatment, 2020, pp. 175–210. Scopus, doi:10.1016/B978-0-12-816022-0.00007-7. Full Text
Jack, J., et al. “Mapping rhetorical topologies in cognitive neuroscience.” Topologies as Techniques for a Post-Critical Rhetoric, 2017, pp. 125–50. Scopus, doi:10.1007/978-3-319-51268-6_7. Full Text
Young, Jonathan R., et al. “Transcranial Magnetic Stimulation Treatment for Smoking Cessation: An Introduction for Primary Care Clinicians.” Am J Med, Aug. 2021. Pubmed, doi:10.1016/j.amjmed.2021.06.037. Full Text
Fogt, Nick, et al. “Guest Editorial: Visual Function and Sports Performance.” Optom Vis Sci, vol. 98, no. 7, July 2021, pp. 669–71. Pubmed, doi:10.1097/OPX.0000000000001717. Full Text
Laby, Daniel M., and Lawrence Gregory Appelbaum. “Review: Vision and On-field Performance: A Critical Review of Visual Assessment and Training Studies with Athletes.” Optom Vis Sci, vol. 98, no. 7, July 2021, pp. 723–31. Pubmed, doi:10.1097/OPX.0000000000001729. Full Text
Laby, Daniel M., and Lawrence G. Appelbaum. “Comment on Nascimento et al. Citations Network Analysis of Vision and Sport. Int. J. Environ. Res. Public Health 2020, 17, 7574.” Int J Environ Res Public Health, vol. 18, no. 12, June 2021. Pubmed, doi:10.3390/ijerph18126488. Full Text
Liu, Sicong, et al. “Psychophysiological Markers of Performance and Learning during Simulated Marksmanship in Immersive Virtual Reality.” J Cogn Neurosci, vol. 33, no. 7, June 2021, pp. 1253–70. Pubmed, doi:10.1162/jocn_a_01713. Full Text
Beynel, Lysianne, et al. “The Effects of Functionally Guided, Connectivity-Based rTMS on Amygdala Activation.” Brain Sci, vol. 11, no. 4, Apr. 2021. Pubmed, doi:10.3390/brainsci11040494. Full Text
Neacsiu, Andrada, et al. Enhancing Cognitive Restructuring with Concurrent Repetitive Transcranial Magnetic Stimulation: A Transdiagnostic Randomized Controlled Trial. Jan. 2021. Epmc, doi:10.1101/2021.01.18.21250060. Full Text
Liu, S., et al. “Dynamic vision training transfers positively to batting practice performance among collegiate baseball batters.” Psychology of Sport and Exercise, vol. 51, Nov. 2020. Scopus, doi:10.1016/j.psychsport.2020.101759. Full Text Open Access Copy
Gamboa Arana, Olga Lucia, et al. “Intensity- and timing-dependent modulation of motion perception with transcranial magnetic stimulation of visual cortex.” Neuropsychologia, vol. 147, Oct. 2020, p. 107581. Pubmed, doi:10.1016/j.neuropsychologia.2020.107581. Full Text Open Access Copy
Powers, John P., et al. “Examining the Role of Lateral Parietal Cortex in Emotional Distancing Using TMS.” Cogn Affect Behav Neurosci, vol. 20, no. 5, Oct. 2020, pp. 1090–102. Pubmed, doi:10.3758/s13415-020-00821-5. Full Text Open Access Copy
Clements, J. M., et al. “Neurophysiology of Visual-Motor Learning during a Simulated Marksmanship Task in Immersive Virtual Reality.” 25th Ieee Conference on Virtual Reality and 3d User Interfaces, Vr 2018 Proceedings, 2018, pp. 451–58. Scopus, doi:10.1109/VR.2018.8446068. Full Text Open Access Copy
Zielinski, D. J., et al. “Evaluating the effects of image persistence on dynamic target acquisition in low frame rate virtual environments.” Proceedings Ieee Virtual Reality, vol. 2016-July, 2016, pp. 319–20. Scopus, doi:10.1109/VR.2016.7504782. Full Text
Donohue, Sarah E., et al. “THE EFFECTS OF RESPONSE NUMBER AND TASK ON THE ELECTROPHYSIOLOGICAL CORRELATES OF CONFLICT PROCESSING.” Journal of Cognitive Neuroscience, 2013, pp. 102–102.
Martin, Rene San, et al. “NEURAL SIGNATURES OF VALUE-DRIVEN ATTENTIONAL CAPTURE PREDICT INDIVIDUAL DIFFERENCES IN ECONOMIC CHOICE.” Journal of Cognitive Neuroscience, 2013, pp. 208–208.