Lawrence Gregory Appelbaum

Lawrence Gregory Appelbaum

Associate Professor in Psychiatry and Behavioral Sciences

External Address: 
Duke Hospital South, 5th Floor, Red Zone, Room 54231, Durham, NC 27710
Internal Office Address: 
Box 3620, Durham, NC 27710
Phone: 
919.613.7664

Overview

Greg Appelbaum is an Associate Professor in the Department of Psychiatry and Behavioral Sciences in the Duke University School of Medicine. He is a member of the Brain Stimulation Division of Psychiatry, where he directs the Human Performance Optimization lab (Opti Lab) and the Brain Stimulation Research Center.  Dr. Appelbaum core member of the Center for Cognitive Neuroscience, holds a secondary appointment in the Department of Psychology and Neuroscience, and is a member of the Duke Institute for Brain Sciences where he teaches and advises in the Neuroscience major.

Dr. Appelbaum's research interests primarily concern the brain mechanisms underlying visual cognition, how these capabilities differ among individuals, and how they can be improved through behavioral, neurofeedback, and neuromodulation interventions. Within the field of cognitive neuroscience, his research has addressed visual perception, sensorimotor function, executive function, decision-making, and learning/expertise. In this research, he has utilized a combination of behavioral psychophysics coupled with the neuroscience techniques of electroencephalography (EEG), transcranial magnetic stimulation (TMS), functional magnetic resonance imaging (fMRI), and functional near infrared spectroscopy (fNIRS). 

Education & Training

  • Ph.D., University of California - Irvine 2004

Selected Grants

Using network-guided TMS to ameliorate memory deficits in early Alzheimer's disease awarded by National Institutes of Health (Co Investigator). 2020 to 2022

Identifying the Optimal Neural Target for Misophonia Interventions awarded by The REAM Foundation (Co Investigator). 2019 to 2021

Impact of Timing, Targeting, and Brain State on rTMS of Human and Non-Human Primates awarded by National Institutes of Health (Co Investigator). 2017 to 2021

Transcranial magnetic stimulation with enhanced focality and depth (fdTMS) awarded by National Institutes of Health (Advisor). 2017 to 2021

Quiet TMS: A Low-Acoustic-Noise Transcranial Magnetic Stimulation System awarded by National Institutes of Health (Co Investigator). 2016 to 2021

Using fMRI-guided TMS to increase central executive function in older adults awarded by National Institutes of Health (Principal Investigator). 2015 to 2021

Neurophysiology and Cognitive Neuroscience (8.4): Sensorimotor Function in Elite Soldiers and Athletes awarded by Department of Defense (Principal Investigator). 2015 to 2021

Accurate and reliable computational dosimetry and targeting for transcranial magnetic stimulation awarded by National Institutes of Health (Collaborator). 2019 to 2020

Tracking Neurological Function in Warrior-Athletes: A Multidisciplinary Approach awarded by University of North Carolina - Chapel Hill (Principal Investigator). 2014 to 2015

Pages

Beynel, L., et al. “Neurobiology and neuromodulation of emotion in PTSD.” Emotion in Posttraumatic Stress Disorder: Etiology, Assessment, Neurobiology, and Treatment, 2020, pp. 175–210. Scopus, doi:10.1016/B978-0-12-816022-0.00007-7. Full Text

Jack, J., et al. “Mapping rhetorical topologies in cognitive neuroscience.” Topologies as Techniques for a Post-Critical Rhetoric, 2017, pp. 125–50. Scopus, doi:10.1007/978-3-319-51268-6_7. Full Text

Liu, S., et al. “Dynamic vision training transfers positively to batting practice performance among collegiate baseball batters.” Psychology of Sport and Exercise, vol. 51, Nov. 2020. Scopus, doi:10.1016/j.psychsport.2020.101759. Full Text Open Access Copy

Gamboa Arana, Olga Lucia, et al. “Intensity- and timing-dependent modulation of motion perception with transcranial magnetic stimulation of visual cortex.Neuropsychologia, vol. 147, Oct. 2020, p. 107581. Pubmed, doi:10.1016/j.neuropsychologia.2020.107581. Full Text Open Access Copy

Powers, John P., et al. “Examining the Role of Lateral Parietal Cortex in Emotional Distancing Using TMS.Cognitive, Affective & Behavioral Neuroscience, vol. 20, no. 5, Oct. 2020, pp. 1090–102. Epmc, doi:10.3758/s13415-020-00821-5. Full Text Open Access Copy

Crowell, C. A., et al. “Older adults benefit from more widespread brain network integration during working memory.Neuroimage, vol. 218, Sept. 2020, p. 116959. Pubmed, doi:10.1016/j.neuroimage.2020.116959. Full Text Open Access Copy

Beynel, Lysianne, et al. “Structural Controllability Predicts Functional Patterns and Brain Stimulation Benefits Associated with Working Memory.J Neurosci, vol. 40, no. 35, Aug. 2020, pp. 6770–78. Pubmed, doi:10.1523/JNEUROSCI.0531-20.2020. Full Text

Liu, S., et al. “Visual and oculomotor abilities predict professional baseball batting performance.” International Journal of Performance Analysis in Sport, vol. 20, no. 4, July 2020, pp. 683–700. Scopus, doi:10.1080/24748668.2020.1777819. Full Text Open Access Copy

Gamboa, Olga Lucia, et al. “Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination.Neurosci Lett, vol. 730, June 2020, p. 135022. Pubmed, doi:10.1016/j.neulet.2020.135022. Full Text Open Access Copy

Cox, Morgan L., et al. “Utilizing transcranial direct current stimulation to enhance laparoscopic technical skills training: A randomized controlled trial.Brain Stimul, vol. 13, no. 3, May 2020, pp. 863–72. Pubmed, doi:10.1016/j.brs.2020.03.009. Full Text Open Access Copy

Beynel, Lysianne, et al. “Site-Specific Effects of Online rTMS during a Working Memory Task in Healthy Older Adults.Brain Sci, vol. 10, no. 5, Apr. 2020. Pubmed, doi:10.3390/brainsci10050255. Full Text Open Access Copy

Young, Jonathan R., et al. “Non-invasive brain stimulation modalities for the treatment and prevention of opioid use disorder: a systematic review of the literature.J Addict Dis, vol. 38, no. 2, Apr. 2020, pp. 186–99. Pubmed, doi:10.1080/10550887.2020.1736756. Full Text Open Access Copy

Pages

Clements, J. M., et al. “Neurophysiology of Visual-Motor Learning during a Simulated Marksmanship Task in Immersive Virtual Reality.” 25th Ieee Conference on Virtual Reality and 3d User Interfaces, Vr 2018  Proceedings, 2018, pp. 451–58. Scopus, doi:10.1109/VR.2018.8446068. Full Text Open Access Copy

Zielinski, D. J., et al. “Evaluating the effects of image persistence on dynamic target acquisition in low frame rate virtual environments.” Proceedings  Ieee Virtual Reality, vol. 2016-July, 2016, pp. 319–20. Scopus, doi:10.1109/VR.2016.7504782. Full Text

Donohue, Sarah E., et al. “THE EFFECTS OF RESPONSE NUMBER AND TASK ON THE ELECTROPHYSIOLOGICAL CORRELATES OF CONFLICT PROCESSING.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 102–102.

Martin, Rene San, et al. “NEURAL SIGNATURES OF VALUE-DRIVEN ATTENTIONAL CAPTURE PREDICT INDIVIDUAL DIFFERENCES IN ECONOMIC CHOICE.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 208–208.