Marc G. Caron

Marc G. Caron

James B. Duke Distinguished Professor of Cell Biology

External Address: 
CARL Building Room 487, Durham, NC 27710
Internal Office Address: 
Duke Box 3287, Durham, NC 27710
Phone: 
919.684.5433

Overview

Studies of the mechanisms of action and regulation of hormones and neurotransmitters at the cellular and molecular levels constitute the main goals our of research activities. G protein-coupled receptors (GPCR) mediate the actions of signaling molecules from unicellular organisms to man. We have used adrenergic and dopamine receptors to characterize the structure/function and regulation mechanisms of these prototypes of G protein-coupled receptors. Another approach has been to characterize the nature of neurotransmitter transporters for dopamine, serotonin and other neurotransmitters in an attempt to understand their function in normal and pathological neurotransmission. Another goal of our laboratory is to define the genes and pathways involved in the reinforcing properties of drugs of abuse using both forward and reverse genetic approaches. Our laboratory uses biochemical, molecular biology and gene targeting approaches to examine these questions.

Education & Training

  • Ph.D., University of Miami 1973

Selected Grants

Cell and Molecular Biology Training Program awarded by National Institutes of Health (Mentor). 2021 to 2026

Pharmacological Sciences Training Grant awarded by National Institutes of Health (Preceptor). 2020 to 2025

Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Functional and Mechanistic Dissection of GPCR Endosomal Signaling Dynamics awarded by National Institutes of Health (Co-Sponsor). 2021 to 2024

Exploiting Biased Agonism at the Ghrelin Receptor (GHSR 1a) for Opioid Addiction awarded by National Institutes of Health (Principal Investigator). 2020 to 2023

Translational Research in Surgical Oncology awarded by National Institutes of Health (Mentor). 2002 to 2022

Duke Training Grant in Nephrology awarded by National Institutes of Health (Preceptor). 1995 to 2022

Leveraging Functional Selectivity in the Neurotensin Receptor 1-Mediated Treatment of Addiction awarded by National Institutes of Health (Mentor). 2019 to 2022

A console for magnetic resonance histology awarded by North Carolina Biotechnology Center (Major User). 2021 to 2022

Pages

Lefkowitz, R. J., et al. Biochemical mechanisms for regulation of β adrenergic receptors by β adrenergic agonists. Vol. No. 402, 1977, pp. 502–06.

Caron, M. G., and R. R. Gainetdinov. “Role of Dopamine Transporters in Neuronal Homeostasis.” Dopamine Handbook, 2010. Scopus, doi:10.1093/acprof:oso/9780195373035.003.0007. Full Text

Laakso, A., and M. G. Caron. “Dopamine Receptors.” Primer on the Autonomic Nervous System: Second Edition, 2004, pp. 39–43. Scopus, doi:10.1016/B978-012589762-4/50010-4. Full Text

Martini, Michael L., et al. “Addition to "Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity".Acs Chem Neurosci, vol. 12, no. 8, Apr. 2021, p. 1464. Pubmed, doi:10.1021/acschemneuro.1c00186. Full Text

Slosky, Lauren M., et al. “Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.Trends Pharmacol Sci, vol. 42, no. 4, Apr. 2021, pp. 283–99. Pubmed, doi:10.1016/j.tips.2020.12.005. Full Text

Smith, Jeffrey S., et al. “Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors.Science, vol. 371, no. 6534, Mar. 2021. Pubmed, doi:10.1126/science.aay1833. Full Text

Turu, Gábor, et al. “Biased Coupling to β-Arrestin of Two Common Variants of the CB2 Cannabinoid Receptor.Front Endocrinol (Lausanne), vol. 12, 2021, p. 714561. Pubmed, doi:10.3389/fendo.2021.714561. Full Text

Favier, Mathieu, et al. “Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating.J Clin Invest, vol. 130, no. 12, Dec. 2020, pp. 6616–30. Pubmed, doi:10.1172/JCI138532. Full Text

Porter-Stransky, Kirsten A., et al. “Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids.Addict Biol, vol. 25, no. 6, Nov. 2020, p. e12823. Pubmed, doi:10.1111/adb.12823. Full Text

Slosky, Lauren M., et al. “β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.Cell, vol. 181, no. 6, June 2020, pp. 1364-1379.e14. Pubmed, doi:10.1016/j.cell.2020.04.053. Full Text

Li, Yan-Chun, et al. “Deletion of Glycogen Synthase Kinase-3β in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.Biol Psychiatry, vol. 87, no. 8, Apr. 2020, pp. 745–55. Pubmed, doi:10.1016/j.biopsych.2019.10.025. Full Text

Boone, Peter G., et al. “A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.Nat Commun, vol. 10, no. 1, Dec. 2019, p. 5490. Pubmed, doi:10.1038/s41467-019-13330-y. Full Text

Jacobsen, Jacob P. R., et al. “Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept.Neuropsychopharmacology, vol. 44, no. 12, Nov. 2019, pp. 2082–90. Pubmed, doi:10.1038/s41386-019-0400-1. Full Text

Pages

Lajiness, M. E., et al. “Signaling mechanisms of D2, D3, and D4 dopamine receptors determined in transfected cell lines.” Clinical Neuropharmacology, vol. 18, no. SUPPL. 1, 1995. Scopus, doi:10.1097/00002826-199501001-00004. Full Text