Michael Lucas James

Michael Lucas James

Associate Professor of Anesthesiology

External Address: 
5619D Hafs Building, Durham, NC 27710
Internal Office Address: 
Box 3094 Med Ctr, Durham, NC 27710


I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.

After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.

While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.

In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.

Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.

Education & Training

  • M.D., Louisiana State University 1999

Selected Grants

Intrepid- BMD-1111 awarded by Bard Medical Division (Principal Investigator). 2017 to 2023

Novartis Phase II BAF312 in Stroke ICH awarded by Novartis Pharmaceuticals Corporation (Principal Investigator). 2018 to 2022

HOBIT Trial awarded by Minneapolis Medical Research Foundation (Principal Investigator). 2017 to 2022

Recovery and Outcome from StrokE (ROSE) (ICH Recovery Grant) awarded by University of Cincinnati (Principal Investigator). 2017 to 2022

NICO BrainPath Intracerebral Hemorrhage Evacuation Sample Analysis awarded by NICO Corporation (Principal Investigator). 2017 to 2021

Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3) awarded by University of Michigan (Principal Investigator). 2019 to 2020

CN105 to improve long-term recovery in models of intracerebral hemorrhage awarded by AegisCN LLC (Principal Investigator). 2018 to 2020

CN-105 Study awarded by AegisCN LLC (Principal Investigator). 2016 to 2020

Genetic and Environmental Risk Factors for Hemorrhagic Stroke awarded by University of Cincinnati (Principal Investigator). 2017 to 2020


Crocco, L., et al. Emerging electromagnetic technologies for brain diseases diagnostics, monitoring and therapy. 2018, pp. 1–241. Scopus, doi:10.1007/978-3-319-75007-1. Full Text

Faulkner, Amanda, and michael James. “Neurosurgery.” Perioperative Medicine Managing for Outcome, 2021.

Crocco, L., et al. Preface. 2018, pp. v–ix. Scopus, doi:10.1007/978-3-319-75007-1. Full Text

James, M. L., et al. “Flow Arrest in Cerebrovascular Surgery.” Essentials of Neuroanesthesia, 2017, pp. 367–74. Scopus, doi:10.1016/B978-0-12-805299-0.00021-X. Full Text

Chen, Fangyu, et al. “Echocardiogram Utilization Patterns and Association With Mortality Following Severe Traumatic Brain Injury.Anesth Analg, Aug. 2020. Pubmed, doi:10.1213/ANE.0000000000005110. Full Text Open Access Copy

Biffi, Alessandro, et al. “Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage.Stroke, vol. 51, no. 7, July 2020, pp. 2153–60. Pubmed, doi:10.1161/STROKEAHA.120.028310. Full Text

Divani, Afshin A., et al. “The Magnitude of Blood Pressure Reduction Predicts Poor In-Hospital Outcome in Acute Intracerebral Hemorrhage.Neurocrit Care, June 2020. Pubmed, doi:10.1007/s12028-020-01016-z. Full Text

Lei, Beilei, et al. “Author Correction: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.Sci Rep, vol. 10, no. 1, Apr. 2020, p. 6898. Pubmed, doi:10.1038/s41598-020-63178-2. Full Text

Liu, Li, et al. “Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome.Stroke, vol. 51, no. 4, Apr. 2020, pp. 1135–41. Pubmed, doi:10.1161/STROKEAHA.119.028406. Full Text

James, Michael L., et al. “Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury.Neurotherapeutics, vol. 17, no. 2, Apr. 2020, pp. 475–83. Pubmed, doi:10.1007/s13311-020-00858-x. Full Text

Hemphill, J. Claude, and Michael L. James. “Translational Neurocritical Care Research: Advancing Understanding and Developing Therapeutics.Neurotherapeutics, vol. 17, no. 2, Apr. 2020, pp. 389–91. Pubmed, doi:10.1007/s13311-020-00867-w. Full Text

Cooter, Mary, et al. “Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis.Br J Anaesth, vol. 124, no. 1, Jan. 2020, pp. e4–7. Pubmed, doi:10.1016/j.bja.2019.09.036. Full Text

Uniken Venema, Simone M., et al. “Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage.Stroke, vol. 50, no. 10, Oct. 2019, pp. 2722–28. Pubmed, doi:10.1161/STROKEAHA.119.025061. Full Text

Ni, Katherine, et al. “Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values.Br J Anaesth, vol. 123, no. 3, Sept. 2019, pp. 288–97. Pubmed, doi:10.1016/j.bja.2019.05.040. Full Text


Kittner, Steven J., et al. “Similarities and Differences in Intracerebral Hemorrhage Risk Factors by Race/Ethnicity.” Neurology, vol. 92, no. 15, LIPPINCOTT WILLIAMS & WILKINS, 2019.

Islam, M., et al. “ICHNet: Intracerebral hemorrhage (ICH) segmentation using deep learning.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11383 LNCS, 2019, pp. 456–63. Scopus, doi:10.1007/978-3-030-11723-8_46. Full Text

Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S149–50.


Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S265–S265.

Ormseth, Cora, et al. “Racial Variation in Comfort Measures Only Status in Patients with Intracerebral Hemorrhage.” Neurology, vol. 90, LIPPINCOTT WILLIAMS & WILKINS, 2018.

Marini, Sandro, et al. “Comparison of Genetic Ancestry versus Self-Identified Race and Ethnicity as Risk Factor for Intracerebral Hemorrhage.” Stroke, vol. 49, LIPPINCOTT WILLIAMS & WILKINS, 2018.

Ormseth, Cora H., et al. “Racial Variation in Comfort Measures Only Status in Patients With Intracerebral Hemorrhage.” Stroke, vol. 49, LIPPINCOTT WILLIAMS & WILKINS, 2018.

Ding, Dale, et al. “Venous Thromboembolism Complications in Patients with Spontaneous Intracerebral Hemorrhage: A Multicenter Cohort Study.” Journal of Neurosurgery, vol. 126, no. 4, AMER ASSOC NEUROLOGICAL SURGEONS, 2017, pp. A1434–A1434.