Michael Lucas James

Michael Lucas James

Associate Professor of Anesthesiology

External Address: 
5619D Hafs Building, Durham, NC 27710
Internal Office Address: 
Box 3094 Med Ctr, Durham, NC 27710


I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.

After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.

While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.

In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.

Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.

Education & Training

  • M.D., Louisiana State University 1999

Selected Grants

Intrepid- BMD-1111 awarded by Bard Medical Division (Principal Investigator). 2017 to 2023

NICO BrainPath Intracerebral Hemorrhage Evacuation Sample Analysis awarded by NICO Corporation (Principal Investigator). 2017 to 2022

HOBIT Trial awarded by Minneapolis Medical Research Foundation (Principal Investigator). 2017 to 2022

Recovery and Outcome from StrokE (ROSE) (ICH Recovery Grant) awarded by University of Cincinnati (Principal Investigator). 2017 to 2022

Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3) awarded by University of Michigan (Principal Investigator). 2019 to 2021

CN-105 Study awarded by AegisCN LLC (Principal Investigator). 2016 to 2021

Genetic and Environmental Risk Factors for Hemorrhagic Stroke awarded by University of Cincinnati (Principal Investigator). 2017 to 2020

Novartis Phase II BAF312 in Stroke ICH awarded by Novartis Pharmaceuticals Corporation (Principal Investigator). 2018 to 2020


Crocco, L., et al. Emerging electromagnetic technologies for brain diseases diagnostics, monitoring and therapy. 2018, pp. 1–241. Scopus, doi:10.1007/978-3-319-75007-1. Full Text

Faulkner, Amanda, and michael James. “Neurosurgery.” Perioperative Medicine Managing for Outcome, 2021.

James, M. L., et al. “Flow Arrest in Cerebrovascular Surgery.” Essentials of Neuroanesthesia, 2017, pp. 367–74. Scopus, doi:10.1016/B978-0-12-805299-0.00021-X. Full Text

Garreta, A., et al. “Preface.” Brouillon Pour Un Dictionnaire Des Amantes, Grasset &n Fasquelle, 2011.

Komisarow, Jordan M., et al. “Epidemiology and Outcomes of Acute Respiratory Distress Syndrome Following Isolated Severe Traumatic Brain Injury.Journal of Intensive Care Medicine, vol. 37, no. 1, Jan. 2022, pp. 68–74. Epmc, doi:10.1177/0885066620972001. Full Text Open Access Copy

Komisarow, Jordan M., et al. “Utilization of Brain Tissue Oxygenation Monitoring and Association with Mortality Following Severe Traumatic Brain Injury.Neurocritical Care, Nov. 2021. Epmc, doi:10.1007/s12028-021-01394-y. Full Text

Wang, Haichen, et al. “Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage.Neurocrit Care, vol. 35, no. 2, Oct. 2021, pp. 441–50. Pubmed, doi:10.1007/s12028-020-01184-y. Full Text

Luu, David, et al. “Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury.Neurocritical Care, vol. 35, no. 2, Oct. 2021, pp. 434–40. Epmc, doi:10.1007/s12028-020-01183-z. Full Text Open Access Copy

Kang, J. H., et al. “Anticoagulation after Spontaneous Intraparenchymal Hemorrhage in Patients with Mechanical Heart Valves and Concomitant Atrial Fibrillation.” Journal of Neuroanaesthesiology and Critical Care, vol. 8, no. 3, Sept. 2021, pp. 203–07. Scopus, doi:10.1055/s-0041-1735653. Full Text

James, Michael L., et al. “CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.Neurocritical Care, Aug. 2021. Epmc, doi:10.1007/s12028-021-01287-0. Full Text Open Access Copy

Kittner, Steven J., et al. “Ethnic and Racial Variation in Intracerebral Hemorrhage Risk Factors and Risk Factor Burden.Jama Netw Open, vol. 4, no. 8, Aug. 2021, p. e2121921. Pubmed, doi:10.1001/jamanetworkopen.2021.21921. Full Text

Claassen, Jan, et al. “Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.Neurocrit Care, vol. 35, no. Suppl 1, July 2021, pp. 4–23. Pubmed, doi:10.1007/s12028-021-01260-x. Full Text


Shah, Shreyansh, et al. “Abstract P527: Temporal Trend of Mechanical Thrombectomy Utilization in Treatment of Perioperative Ischemic Stroke Following Elective Inpatient Surgery in the United States.” Stroke, vol. 52, no. Suppl_1, Ovid Technologies (Wolters Kluwer Health), 2021. Crossref, doi:10.1161/str.52.suppl_1.p527. Full Text

Kittner, Steven J., et al. “Similarities and Differences in Intracerebral Hemorrhage Risk Factors by Race/Ethnicity.” Neurology, vol. 92, no. 15, LIPPINCOTT WILLIAMS & WILKINS, 2019.

Islam, M., et al. “ICHNet: Intracerebral hemorrhage (ICH) segmentation using deep learning.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11383 LNCS, 2019, pp. 456–63. Scopus, doi:10.1007/978-3-030-11723-8_46. Full Text

Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S265–S265.

Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S149–50.


Ormseth, Cora, et al. “Racial Variation in Comfort Measures Only Status in Patients with Intracerebral Hemorrhage.” Neurology, vol. 90, LIPPINCOTT WILLIAMS & WILKINS, 2018.

Marini, Sandro, et al. “Comparison of Genetic Ancestry versus Self-Identified Race and Ethnicity as Risk Factor for Intracerebral Hemorrhage.” Stroke, vol. 49, LIPPINCOTT WILLIAMS & WILKINS, 2018.