Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Intrepid- BMD-1111 awarded by Bard Medical Division (Principal Investigator). 2017 to 2023
HOBIT Trial awarded by Minneapolis Medical Research Foundation (Principal Investigator). 2017 to 2022
Recovery and Outcome from StrokE (ROSE) (ICH Recovery Grant) awarded by University of Cincinnati (Principal Investigator). 2017 to 2022
NICO BrainPath Intracerebral Hemorrhage Evacuation Sample Analysis awarded by NICO Corporation (Principal Investigator). 2017 to 2021
Novartis Phase II BAF312 in Stroke ICH awarded by Novartis Pharmaceuticals Corporation (Principal Investigator). 2018 to 2020
SETPOINT 2: A pragmatic trial to test the effectiveness of early vs. delayed percutaneous tracheostomy in patients with severe stroke and respiratory failure. awarded by Maine Medical Center Research Institute (Principal Investigator). 2017 to 2020
Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3) awarded by University of Michigan (Principal Investigator). 2019 to 2020
CN105 to improve long-term recovery in models of intracerebral hemorrhage awarded by AegisCN LLC (Principal Investigator). 2018 to 2020
CN-105 Study awarded by AegisCN LLC (Principal Investigator). 2016 to 2020
Genetic and Environmental Risk Factors for Hemorrhagic Stroke awarded by University of Cincinnati (Principal Investigator). 2017 to 2020
Faulkner, Amanda, and michael James. “Neurosurgery.” Perioperative Medicine Managing for Outcome, 2021.
Komisarow, Jordan M., et al. “Epidemiology and Outcomes of Acute Respiratory Distress Syndrome Following Isolated Severe Traumatic Brain Injury.” J Intensive Care Med, Nov. 2020, p. 885066620972001. Pubmed, doi:10.1177/0885066620972001. Full Text
Wang, Haichen, et al. Neuroprotective pentapeptide, CN-105, improves outcomes in translational models of intracerebral hemorrhage. Oct. 2020. Epmc, doi:10.1101/2020.10.15.339184. Full Text
Divani, Afshin A., et al. “The Magnitude of Blood Pressure Reduction Predicts Poor In-Hospital Outcome in Acute Intracerebral Hemorrhage.” Neurocrit Care, vol. 33, no. 2, Oct. 2020, pp. 389–98. Pubmed, doi:10.1007/s12028-020-01016-z. Full Text
Chen, Fangyu, et al. “Echocardiogram Utilization Patterns and Association With Mortality Following Severe Traumatic Brain Injury.” Anesth Analg, Aug. 2020. Pubmed, doi:10.1213/ANE.0000000000005110. Full Text Open Access Copy
Biffi, Alessandro, et al. “Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage.” Stroke, vol. 51, no. 7, July 2020, pp. 2153–60. Pubmed, doi:10.1161/STROKEAHA.120.028310. Full Text
Lei, Beilei, et al. “Author Correction: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.” Sci Rep, vol. 10, no. 1, Apr. 2020, p. 6898. Pubmed, doi:10.1038/s41598-020-63178-2. Full Text
Liu, Li, et al. “Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome.” Stroke, vol. 51, no. 4, Apr. 2020, pp. 1135–41. Pubmed, doi:10.1161/STROKEAHA.119.028406. Full Text
James, Michael L., et al. “Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury.” Neurotherapeutics, vol. 17, no. 2, Apr. 2020, pp. 475–83. Pubmed, doi:10.1007/s13311-020-00858-x. Full Text
Hemphill, J. Claude, and Michael L. James. “Translational Neurocritical Care Research: Advancing Understanding and Developing Therapeutics.” Neurotherapeutics, vol. 17, no. 2, Apr. 2020, pp. 389–91. Pubmed, doi:10.1007/s13311-020-00867-w. Full Text
Cooter, Mary, et al. “Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis.” British Journal of Anaesthesia, vol. 124, no. 1, Jan. 2020, pp. e4–7. Epmc, doi:10.1016/j.bja.2019.09.036. Full Text
Kittner, Steven J., et al. “Similarities and Differences in Intracerebral Hemorrhage Risk Factors by Race/Ethnicity.” Neurology, vol. 92, no. 15, LIPPINCOTT WILLIAMS & WILKINS, 2019.
Woo, Daniel, et al. “Predictors of Poor Outcome After Intracerebral Hemorrhage: Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.” Stroke, vol. 50, LIPPINCOTT WILLIAMS & WILKINS, 2019.
Islam, M., et al. “ICHNet: Intracerebral hemorrhage (ICH) segmentation using deep learning.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11383 LNCS, 2019, pp. 456–63. Scopus, doi:10.1007/978-3-030-11723-8_46. Full Text
Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S265–S265.
Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S149–50.
Ng, Y., et al. “EFFECT OF ANTIHYPERTENSIVE AGENT CHOICE ON BLOOD PRESSURE RESPONSE AND OUTCOME IN ACUTE INTRACEREBRAL HEMORRHAGE.” International Journal of Stroke, vol. 13, SAGE PUBLICATIONS LTD, 2018, pp. 39–39.
Ormseth, Cora, et al. “Racial Variation in Comfort Measures Only Status in Patients with Intracerebral Hemorrhage.” Neurology, vol. 90, LIPPINCOTT WILLIAMS & WILKINS, 2018.
Marini, Sandro, et al. “Comparison of Genetic Ancestry versus Self-Identified Race and Ethnicity as Risk Factor for Intracerebral Hemorrhage.” Stroke, vol. 49, LIPPINCOTT WILLIAMS & WILKINS, 2018.
Ormseth, Cora H., et al. “Racial Variation in Comfort Measures Only Status in Patients With Intracerebral Hemorrhage.” Stroke, vol. 49, LIPPINCOTT WILLIAMS & WILKINS, 2018.
Ding, Dale, et al. “Venous Thromboembolism Complications in Patients with Spontaneous Intracerebral Hemorrhage: A Multicenter Cohort Study.” Journal of Neurosurgery, vol. 126, no. 4, AMER ASSOC NEUROLOGICAL SURGEONS, 2017, pp. A1434–A1434.