Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Novartis Phase II BAF312 in Stroke ICH awarded by (Principal Investigator). 2018 to 2022
HOBIT Trial awarded by (Principal Investigator). 2017 to 2022
NICO BrainPath Intracerebral Hemorrhage Evacuation Sample Analysis awarded by (Principal Investigator). 2017 to 2021
SETPOINT 2: A pragmatic trial to test the effectiveness of early vs. delayed percutaneous tracheostomy in patients with severe stroke and respiratory failure. awarded by (Principal Investigator). 2017 to 2020
Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3) awarded by University of Michigan (Principal Investigator). 2019 to 2020
CN105 to improve long-term recovery in models of intracerebral hemorrhage awarded by (Principal Investigator). 2018 to 2020
Intrepid- BMD-1111 awarded by (Principal Investigator). 2017 to 2020
ROSE awarded by University of Cincinnati (Principal Investigator). 2017 to 2020
CN-105 Study awarded by (Principal Investigator). 2016 to 2020
Genetic and Environmental Risk Factors for Hemorrhagic Stroke awarded by University of Cincinnati (Principal Investigator). 2017 to 2020
Liu, Li, et al. “Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome.” Stroke, Mar. 2020, p. STROKEAHA119028406. Pubmed, doi:10.1161/STROKEAHA.119.028406. Full Text
Cooter, Mary, et al. “Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis.” Br J Anaesth, vol. 124, no. 1, Jan. 2020, pp. e4–7. Pubmed, doi:10.1016/j.bja.2019.09.036. Full Text
Uniken Venema, Simone M., et al. “Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage.” Stroke, vol. 50, no. 10, Oct. 2019, pp. 2722–28. Pubmed, doi:10.1161/STROKEAHA.119.025061. Full Text
Ni, Katherine, et al. “Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values.” Br J Anaesth, vol. 123, no. 3, Sept. 2019, pp. 288–97. Pubmed, doi:10.1016/j.bja.2019.05.040. Full Text
Divani, Afshin A., et al. “Blood Pressure Variability Predicts Poor In-Hospital Outcome in Spontaneous Intracerebral Hemorrhage.” Stroke, vol. 50, no. 8, Aug. 2019, pp. 2023–29. Pubmed, doi:10.1161/STROKEAHA.119.025514. Full Text
Ding, Dale, et al. “Venous Thromboembolism in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter Study.” Neurosurgery, vol. 84, no. 6, June 2019, pp. E304–10. Pubmed, doi:10.1093/neuros/nyy333. Full Text
Awad, Issam A., et al. “Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.” Neurosurgery, vol. 84, no. 6, June 2019, pp. 1157–68. Pubmed, doi:10.1093/neuros/nyz077. Full Text
Selim, Magdy, et al. “Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial.” Lancet Neurol, vol. 18, no. 5, May 2019, pp. 428–38. Pubmed, doi:10.1016/S1474-4422(19)30069-9. Full Text
Xie, Yongqiu, et al. “Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.” Transl Stroke Res, vol. 10, no. 2, Apr. 2019, pp. 231–39. Pubmed, doi:10.1007/s12975-018-0633-z. Full Text
Marini, Sandro, et al. “Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.” Jama Neurol, vol. 76, no. 4, Apr. 2019, pp. 480–91. Pubmed, doi:10.1001/jamaneurol.2018.4519. Full Text
Kittner, Steven J., et al. “Similarities and Differences in Intracerebral Hemorrhage Risk Factors by Race/Ethnicity.” Neurology, vol. 92, no. 15, LIPPINCOTT WILLIAMS & WILKINS, 2019.
Woo, Daniel, et al. “Predictors of Poor Outcome After Intracerebral Hemorrhage: Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.” Stroke, vol. 50, LIPPINCOTT WILLIAMS & WILKINS, 2019.
Islam, M., et al. “ICHNet: Intracerebral hemorrhage (ICH) segmentation using deep learning.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11383 LNCS, 2019, pp. 456–63. Scopus, doi:10.1007/978-3-030-11723-8_46. Full Text
Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S149–50.
Ng, Y., et al. “EFFECT OF ANTIHYPERTENSIVE AGENT CHOICE ON BLOOD PRESSURE RESPONSE AND OUTCOME IN ACUTE INTRACEREBRAL HEMORRHAGE.” International Journal of Stroke, vol. 13, SAGE PUBLICATIONS LTD, 2018, pp. 39–39.
Lei, Beilei, et al. “Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.” Neuroendocrinology, vol. 103, no. 6, 2016, pp. 665–77. Pubmed, doi:10.1159/000442204. Full Text
James, Michael L., et al. “Sex-age Interactions and Differences in Outcomes After Intracerebral Hemorrhage.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
Sheth, Kevin N., et al. “Withdrawal of Care in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.” Stroke, vol. 44, no. 2, LIPPINCOTT WILLIAMS & WILKINS, 2013.