Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
James, Michael L., et al. “S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage.” Biomarkers, vol. 14, no. 6, Sept. 2009, pp. 388–94. Pubmed, doi:10.1080/13547500903015784. Full Text
James, Michael L., et al. “Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans.” J Stroke Cerebrovasc Dis, vol. 18, no. 2, Mar. 2009, pp. 144–49. Pubmed, doi:10.1016/j.jstrokecerebrovasdis.2008.09.012. Full Text
James, Michael L., et al. “Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.” Stroke, vol. 40, no. 2, Feb. 2009, pp. 632–39. Pubmed, doi:10.1161/STROKEAHA.108.530402. Full Text
James, Michael Lucas, et al. “Preclinical models of intracerebral hemorrhage: a translational perspective.” Neurocrit Care, vol. 9, no. 1, 2008, pp. 139–52. Pubmed, doi:10.1007/s12028-007-9030-2. Full Text
Bennett, Stacey S., et al. “Use of high frequency oscillatory ventilation (HFOV) in neurocritical care patients.” Neurocrit Care, vol. 7, no. 3, 2007, pp. 221–26. Pubmed, doi:10.1007/s12028-007-0084-y. Full Text
James, Michael L., and Aatif M. Husain. “Brainstem auditory evoked potential monitoring: when is change in wave V significant?” Neurology, vol. 65, no. 10, Nov. 2005, pp. 1551–55. Pubmed, doi:10.1212/01.wnl.0000184481.75412.2b. Full Text
James, M. L., and M. K. Panni. “Extremely prolonged unilateral block (20 hours) with spinal ropivacaine used for cervical cerclage placement.” Anesth Analg, vol. 100, no. 3, Mar. 2005, pp. 897–98. Pubmed, doi:10.1213/01.ANE.0000146651.78258.83. Full Text