Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Engel, C., et al. “Associations between Features of External Ventricular Drain Management, Disposition, and Shunt Dependence.” Journal of Neuroanaesthesiology and Critical Care, vol. 8, no. 1, Mar. 2021, pp. 28–33. Scopus, doi:10.1055/s-0040-1710410. Full Text Open Access Copy
Wang, Haichen, et al. Neuroprotective pentapeptide, CN-105, improves outcomes in translational models of intracerebral hemorrhage. Oct. 2020. Epmc, doi:10.1101/2020.10.15.339184. Full Text
Divani, Afshin A., et al. “The Magnitude of Blood Pressure Reduction Predicts Poor In-Hospital Outcome in Acute Intracerebral Hemorrhage.” Neurocrit Care, vol. 33, no. 2, Oct. 2020, pp. 389–98. Pubmed, doi:10.1007/s12028-020-01016-z. Full Text
Biffi, Alessandro, et al. “Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage.” Stroke, vol. 51, no. 7, July 2020, pp. 2153–60. Pubmed, doi:10.1161/STROKEAHA.120.028310. Full Text
Lei, Beilei, et al. “Author Correction: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.” Sci Rep, vol. 10, no. 1, Apr. 2020, p. 6898. Pubmed, doi:10.1038/s41598-020-63178-2. Full Text
Liu, Li, et al. “Selective Serotonin Reuptake Inhibitors and Intracerebral Hemorrhage Risk and Outcome.” Stroke, vol. 51, no. 4, Apr. 2020, pp. 1135–41. Pubmed, doi:10.1161/STROKEAHA.119.028406. Full Text
James, Michael L., et al. “Therapeutic Development of Apolipoprotein E Mimetics for Acute Brain Injury: Augmenting Endogenous Responses to Reduce Secondary Injury.” Neurotherapeutics, vol. 17, no. 2, Apr. 2020, pp. 475–83. Pubmed, doi:10.1007/s13311-020-00858-x. Full Text
Hemphill, J. Claude, and Michael L. James. “Translational Neurocritical Care Research: Advancing Understanding and Developing Therapeutics.” Neurotherapeutics, vol. 17, no. 2, Apr. 2020, pp. 389–91. Pubmed, doi:10.1007/s13311-020-00867-w. Full Text
Cooter, Mary, et al. “Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis.” Br J Anaesth, vol. 124, no. 1, Jan. 2020, pp. e4–7. Pubmed, doi:10.1016/j.bja.2019.09.036. Full Text
Uniken Venema, Simone M., et al. “Impact of Cerebral Small Vessel Disease on Functional Recovery After Intracerebral Hemorrhage.” Stroke, vol. 50, no. 10, Oct. 2019, pp. 2722–28. Pubmed, doi:10.1161/STROKEAHA.119.025061. Full Text
Dunning, Karl, et al. “Falls After Intracerebral Hemorrhage.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
Osborne, Jennifer, et al. “Venous Thromboembolism Complications In Patients With Intracerebral Hemorrhage.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
Woo, Daniel, et al. “Intraventricular Hemorrhage and Long-term Incontinencea and Dysmobility After Intracerebral Hemorrhage.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
Kidwell, Chelsea S., et al. “Ischemic Lesions in Intracerebral Hemorrhage Associated with Drop in Blood Pressure and Poor Outcomes in the ERICH Study.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
Kidwell, Chelsea S., et al. “Race/Ethnic Differences in Microbleed Characteristics and Association of Microbleeds with Poor Outcomes in the ERICH Study.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
James, Michael L., et al. “Sex-age Interactions and Differences in Outcomes After Intracerebral Hemorrhage.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
El Husseini, Nada, et al. “SNP rs10940495 in the Gp-130 Locus Is Associated with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.” Neurology, vol. 80, LIPPINCOTT WILLIAMS & WILKINS, 2013.
Sheth, Kevin N., et al. “Withdrawal of Care in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.” Stroke, vol. 44, no. 2, LIPPINCOTT WILLIAMS & WILKINS, 2013.
James, Michael, et al. “VENTRICULOSTOMY AND CSF DRAINAGE IN SAH.” Critical Care Medicine, vol. 37, no. 12, LIPPINCOTT WILLIAMS & WILKINS, 2009, pp. A167–A167.
James, Michael, et al. “BRAIN NATRIURETIC PEPTIDE IMPROVES FUNCTIONAL OUTCOME AFTER ACUTE BRAIN INJURY IN MICE.” Critical Care Medicine, vol. 37, no. 12, LIPPINCOTT WILLIAMS & WILKINS, 2009, pp. A16–A16.