Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Ni, Katherine, et al. “Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values.” Br J Anaesth, vol. 123, no. 3, Sept. 2019, pp. 288–97. Pubmed, doi:10.1016/j.bja.2019.05.040. Full Text
Divani, Afshin A., et al. “Blood Pressure Variability Predicts Poor In-Hospital Outcome in Spontaneous Intracerebral Hemorrhage.” Stroke, vol. 50, no. 8, Aug. 2019, pp. 2023–29. Pubmed, doi:10.1161/STROKEAHA.119.025514. Full Text
Ding, Dale, et al. “Venous Thromboembolism in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter Study.” Neurosurgery, vol. 84, no. 6, June 2019, pp. E304–10. Pubmed, doi:10.1093/neuros/nyy333. Full Text
Awad, Issam A., et al. “Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.” Neurosurgery, vol. 84, no. 6, June 2019, pp. 1157–68. Pubmed, doi:10.1093/neuros/nyz077. Full Text
Selim, Magdy, et al. “Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial.” Lancet Neurol, vol. 18, no. 5, May 2019, pp. 428–38. Pubmed, doi:10.1016/S1474-4422(19)30069-9. Full Text
Marini, Sandro, et al. “Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity: A Meta-analysis.” Jama Neurol, vol. 76, no. 4, Apr. 2019, pp. 480–91. Pubmed, doi:10.1001/jamaneurol.2018.4519. Full Text
Lim, Jia Xu, et al. “External Validation of Hematoma Expansion Scores in Spontaneous Intracerebral Hemorrhage in an Asian Patient Cohort.” Neurocrit Care, vol. 30, no. 2, Apr. 2019, pp. 394–404. Pubmed, doi:10.1007/s12028-018-0631-8. Full Text
Xie, Yongqiu, et al. “Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice.” Transl Stroke Res, vol. 10, no. 2, Apr. 2019, pp. 231–39. Pubmed, doi:10.1007/s12975-018-0633-z. Full Text
Hanley, Daniel F., et al. “Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial.” Lancet, vol. 393, no. 10175, Mar. 2019, pp. 1021–32. Pubmed, doi:10.1016/S0140-6736(19)30195-3. Full Text
Fierro, Michael A., et al. “Renal Angina Is a Sensitive, but Nonspecific Identifier of Postcardiac Surgery Acute Kidney Injury.” J Cardiothorac Vasc Anesth, vol. 33, no. 2, Feb. 2019, pp. 357–64. Pubmed, doi:10.1053/j.jvca.2018.07.017. Full Text