Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Guercio, Jason R., et al. “Spinal cord injury pharmacotherapy: Current research & development and competitive commercial landscape as of 2015.” J Spinal Cord Med, vol. 42, no. 1, Jan. 2019, pp. 102–22. Pubmed, doi:10.1080/10790268.2018.1439803. Full Text
Smith, Patrick J., et al. “Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.” Ann Thorac Surg, vol. 107, no. 1, Jan. 2019, pp. 112–18. Pubmed, doi:10.1016/j.athoracsur.2018.07.056. Full Text Open Access Copy
Ormseth, Cora H., et al. “Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage.” Neurocrit Care, vol. 29, no. 3, Dec. 2018, pp. 419–25. Pubmed, doi:10.1007/s12028-018-0554-4. Full Text
Lee, Lester, et al. “Long-term recovery profile of patients with severe disability or in vegetative states following severe primary intracerebral hemorrhage.” J Crit Care, vol. 48, Dec. 2018, pp. 269–75. Pubmed, doi:10.1016/j.jcrc.2018.09.010. Full Text
Murphy, Meredith P., et al. “Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage.” Stroke, vol. 49, no. 11, Nov. 2018, pp. 2652–58. Pubmed, doi:10.1161/STROKEAHA.118.021799. Full Text
McFarlin, Jessica, et al. “Associations between Patient Characteristics and a New, Early Do-Not-Attempt Resuscitation Order after Intracerebral Hemorrhage.” J Palliat Med, vol. 21, no. 8, Aug. 2018, pp. 1161–65. Pubmed, doi:10.1089/jpm.2017.0519. Full Text
Rodriguez-Torres, Axana, et al. “Hypertension and intracerebral hemorrhage recurrence among white, black, and Hispanic individuals.” Neurology, vol. 91, no. 1, July 2018, pp. e37–44. Pubmed, doi:10.1212/WNL.0000000000005729. Full Text
Anderson, Christopher D., and Michael L. James. “Survival and independence after intracerebral hemorrhage: Trends and opportunities.” Neurology, vol. 90, no. 23, June 2018, pp. 1043–44. Pubmed, doi:10.1212/WNL.0000000000005625. Full Text
Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants, Eike. “Unmet Needs and Challenges in Clinical Research of Intracerebral Hemorrhage.” Stroke, vol. 49, no. 5, May 2018, pp. 1299–307. Pubmed, doi:10.1161/STROKEAHA.117.019541. Full Text
Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants, Alyse. “Basic and Translational Research in Intracerebral Hemorrhage: Limitations, Priorities, and Recommendations.” Stroke, vol. 49, no. 5, May 2018, pp. 1308–14. Pubmed, doi:10.1161/STROKEAHA.117.019539. Full Text