Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Gokhale, Sankalp, et al. “Sex differences in incidence, pathophysiology, and outcome of primary intracerebral hemorrhage.” Stroke, vol. 46, no. 3, Mar. 2015, pp. 886–92. Pubmed, doi:10.1161/STROKEAHA.114.007682. Full Text
Battey, Thomas W. K., et al. “Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage.” Stroke, vol. 46, no. 1, Jan. 2015, pp. 285–90. Pubmed, doi:10.1161/STROKEAHA.114.006851. Full Text
Feix, James A., et al. “Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.” Springerplus, vol. 4, 2015, p. 350. Pubmed, doi:10.1186/s40064-015-1126-0. Full Text Open Access Copy
Warner, David S., et al. “Translational research in acute central nervous system injury: lessons learned and the future.” Jama Neurol, vol. 71, no. 10, Oct. 2014, pp. 1311–18. Pubmed, doi:10.1001/jamaneurol.2014.1238. Full Text
Olson, DaiWai M., et al. “Exploring the impact of augmenting sedation assessment with physiologic monitors.” Aust Crit Care, vol. 27, no. 3, Aug. 2014, pp. 145–50. Pubmed, doi:10.1016/j.aucc.2013.09.001. Full Text
Lei, Beilei, et al. “Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage.” J Vis Exp, no. 89, July 2014. Pubmed, doi:10.3791/51439. Full Text Open Access Copy
James, Michael L., et al. “Predictors of electrocerebral inactivity with deep hypothermia.” J Thorac Cardiovasc Surg, vol. 147, no. 3, Mar. 2014, pp. 1002–07. Pubmed, doi:10.1016/j.jtcvs.2013.03.022. Full Text
Wang, Haichen, et al. “pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH.” Neurocrit Care, vol. 20, no. 1, Feb. 2014, pp. 119–31. Pubmed, doi:10.1007/s12028-013-9944-9. Full Text
James, Michael L., et al. “Insurance status and outcome after intracerebral hemorrhage: findings from Get With The Guidelines-stroke.” J Stroke Cerebrovasc Dis, vol. 23, no. 2, Feb. 2014, pp. 283–92. Pubmed, doi:10.1016/j.jstrokecerebrovasdis.2013.02.016. Full Text