Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
USE OF THE NON-INVASIVE, TIME-VARYING BRAINSTEM STIMULATOR IN PATIENTS WITH IMPAIRED CONSCIOUSNESS: A SAFETY AND FEASIBILITY STUDY awarded by Scion NeuroStim LLC (Principal Investigator). 2022 to 2023
Intrepid- BMD-1111 awarded by Bard Medical Division (Principal Investigator). 2017 to 2023
NICO BrainPath Intracerebral Hemorrhage Evacuation Sample Analysis awarded by NICO Corporation (Principal Investigator). 2017 to 2022
HOBIT Trial awarded by Minneapolis Medical Research Foundation (Principal Investigator). 2017 to 2022
Recovery and Outcome from StrokE (ROSE) (ICH Recovery Grant) awarded by University of Cincinnati (Principal Investigator). 2017 to 2022
Recovery of StrokE Longitudinal Assessment With Neuroimaging awarded by University of Cincinnati (Principal Investigator). 2020 to 2021
Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3) awarded by University of Michigan (Principal Investigator). 2019 to 2021
CN-105 Study awarded by AegisCN LLC (Principal Investigator). 2016 to 2021
SETPOINT 2: A pragmatic trial to test the effectiveness of early vs. delayed percutaneous tracheostomy in patients with severe stroke and respiratory failure. awarded by Maine Medical Center Research Institute (Principal Investigator). 2017 to 2021
Genetic and Environmental Risk Factors for Hemorrhagic Stroke awarded by University of Cincinnati (Principal Investigator). 2017 to 2020
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Lusk, Jay B., et al. “Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.” World Neurosurg, vol. 161, May 2022, pp. 162–68. Pubmed, doi:10.1016/j.wneu.2022.02.062. Full Text
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