Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
USE OF THE NON-INVASIVE, TIME-VARYING BRAINSTEM STIMULATOR IN PATIENTS WITH IMPAIRED CONSCIOUSNESS: A SAFETY AND FEASIBILITY STUDY awarded by Scion NeuroStim LLC (Principal Investigator). 2022 to 2023
Intrepid- BMD-1111 awarded by Bard Medical Division (Principal Investigator). 2017 to 2023
NICO BrainPath Intracerebral Hemorrhage Evacuation Sample Analysis awarded by NICO Corporation (Principal Investigator). 2017 to 2022
HOBIT Trial awarded by Minneapolis Medical Research Foundation (Principal Investigator). 2017 to 2022
Recovery and Outcome from StrokE (ROSE) (ICH Recovery Grant) awarded by University of Cincinnati (Principal Investigator). 2017 to 2022
Recovery of StrokE Longitudinal Assessment With Neuroimaging awarded by University of Cincinnati (Principal Investigator). 2020 to 2021
Brain Oxygen Optimization in Severe Traumatic Brain Injury (BOOST-3) awarded by University of Michigan (Principal Investigator). 2019 to 2021
CN-105 Study awarded by AegisCN LLC (Principal Investigator). 2016 to 2021
SETPOINT 2: A pragmatic trial to test the effectiveness of early vs. delayed percutaneous tracheostomy in patients with severe stroke and respiratory failure. awarded by Maine Medical Center Research Institute (Principal Investigator). 2017 to 2021
Genetic and Environmental Risk Factors for Hemorrhagic Stroke awarded by University of Cincinnati (Principal Investigator). 2017 to 2020
Faulkner, Amanda, and michael James. “Neurosurgery.” Perioperative Medicine Managing for Outcome, 2021.
Garreta, A., et al. “Preface.” Brouillon Pour Un Dictionnaire Des Amantes, Grasset &n Fasquelle, 2011.
Lusk, Jay B., et al. “Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.” World Neurosurg, vol. 161, May 2022, pp. 162–68. Pubmed, doi:10.1016/j.wneu.2022.02.062. Full Text
Ng, Yisi, et al. “Initial antihypertensive agent effects on acute blood pressure after intracerebral haemorrhage.” Stroke Vasc Neurol, Apr. 2022. Pubmed, doi:10.1136/svn-2021-001101. Full Text
Krishnamoorthy, Vijay, et al. “Incidence and Clinical Impact of Myocardial Injury Following Traumatic Brain Injury: A Pilot TRACK-TBI Study.” J Neurosurg Anesthesiol, vol. 34, no. 2, Apr. 2022, pp. 233–37. Pubmed, doi:10.1097/ANA.0000000000000772. Full Text
Komisarow, Jordan M., et al. “Utilization of Brain Tissue Oxygenation Monitoring and Association with Mortality Following Severe Traumatic Brain Injury.” Neurocrit Care, vol. 36, no. 2, Apr. 2022, pp. 350–56. Pubmed, doi:10.1007/s12028-021-01394-y. Full Text
Woo, Daniel, et al. “Risk Factors Associated With Mortality and Neurologic Disability After Intracerebral Hemorrhage in a Racially and Ethnically Diverse Cohort.” Jama Netw Open, vol. 5, no. 3, Mar. 2022, p. e221103. Pubmed, doi:10.1001/jamanetworkopen.2022.1103. Full Text
Toro, Camilo, et al. “Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury.” Anesth Analg, Feb. 2022. Pubmed, doi:10.1213/ANE.0000000000005949. Full Text
Rangaraj, Seshasayi, et al. “Identifying risk factors of intracerebral hemorrhage stability using explainable attention model.” Med Biol Eng Comput, vol. 60, no. 2, Feb. 2022, pp. 337–48. Pubmed, doi:10.1007/s11517-021-02459-y. Full Text
James, Michael L., et al. “CN-105 in Participants with Acute Supratentorial Intracerebral Hemorrhage (CATCH) Trial.” Neurocrit Care, vol. 36, no. 1, Feb. 2022, pp. 216–25. Pubmed, doi:10.1007/s12028-021-01287-0. Full Text Open Access Copy
Toro, Camilo, et al. “Association of Vasopressor Choice with Clinical and Functional Outcomes Following Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Study.” Neurocrit Care, vol. 36, no. 1, Feb. 2022, pp. 180–91. Pubmed, doi:10.1007/s12028-021-01280-7. Full Text
Komisarow, Jordan M., et al. “Epidemiology and Outcomes of Acute Respiratory Distress Syndrome Following Isolated Severe Traumatic Brain Injury.” J Intensive Care Med, vol. 37, no. 1, Jan. 2022, pp. 68–74. Pubmed, doi:10.1177/0885066620972001. Full Text Open Access Copy
Toro, Camilo, et al. “Association of Initial Vasopressor Choice with Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: a TRACK-TBI study.” Anesthesia and Analgesia, vol. 132, no. 5S_SUPPL, 2021, pp. 257–59.
Shah, Shreyansh, et al. “Abstract P527: Temporal Trend of Mechanical Thrombectomy Utilization in Treatment of Perioperative Ischemic Stroke Following Elective Inpatient Surgery in the United States.” Stroke, vol. 52, no. Suppl_1, Ovid Technologies (Wolters Kluwer Health), 2021. Crossref, doi:10.1161/str.52.suppl_1.p527. Full Text
Chen, Fangyu, et al. “Echocardiogram Utilization Patterns and Association with Mortality Following Severe Traumatic Brain Injury: A Retrospective Cohort Study.” Anesthesia and Analgesia, vol. 130, 2020, pp. 228–228.
Kittner, Steven J., et al. “Similarities and Differences in Intracerebral Hemorrhage Risk Factors by Race/Ethnicity.” Neurology, vol. 92, no. 15, LIPPINCOTT WILLIAMS & WILKINS, 2019.
Woo, Daniel, et al. “Predictors of Poor Outcome After Intracerebral Hemorrhage: Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.” Stroke, vol. 50, LIPPINCOTT WILLIAMS & WILKINS, 2019.
Islam, M., et al. “ICHNet: Intracerebral hemorrhage (ICH) segmentation using deep learning.” Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11383 LNCS, 2019, pp. 456–63. Scopus, doi:10.1007/978-3-030-11723-8_46. Full Text
Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S265–S265.
Star, Michael, et al. “Racial and Ethnic Differences in Dysphagia Severity and Feeding Tube Placement after Intracerebral Hemorrhage.” Annals of Neurology, vol. 84, WILEY, 2018, pp. S149–50.
Ng, Y., et al. “EFFECT OF ANTIHYPERTENSIVE AGENT CHOICE ON BLOOD PRESSURE RESPONSE AND OUTCOME IN ACUTE INTRACEREBRAL HEMORRHAGE.” International Journal of Stroke, vol. 13, SAGE PUBLICATIONS LTD, 2018, pp. 39–39.
Ormseth, Cora, et al. “Racial Variation in Comfort Measures Only Status in Patients with Intracerebral Hemorrhage.” Neurology, vol. 90, LIPPINCOTT WILLIAMS & WILKINS, 2018.