Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Novartis Phase II BAF312 in Stroke ICH awarded by Novartis Pharmaceuticals Corporation (Principal Investigator). 2018 to 2020
CN105 to improve long-term recovery in models of intracerebral hemorrhage awarded by AegisCN LLC (Principal Investigator). 2018 to 2020
Futility study of Deferoxamine Mesylate in Intracerebral Hemorrhage (i-Def) awarded by Beth Israel Deaconess Medical Center (Principal Investigator). 2012 to 2019
Dova Avatrombopag for Thrombocytopenia awarded by DOVA Pharmaceuticals (Principal Investigator). 2018 to 2019
Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage awarded by National Institutes of Health (Co Investigator). 2015 to 2018
Cephalogics DOT 3.0 in Cerebral Vasospasm awarded by Cephalogics, LLC (Principal Investigator). 2016 to 2017
Toro, Camilo, et al. “Association of Vasopressor Choice with Clinical and Functional Outcomes Following Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Study.” Neurocrit Care, vol. 36, no. 1, Feb. 2022, pp. 180–91. Pubmed, doi:10.1007/s12028-021-01280-7. Full Text
Rangaraj, Seshasayi, et al. “Identifying risk factors of intracerebral hemorrhage stability using explainable attention model.” Med Biol Eng Comput, vol. 60, no. 2, Feb. 2022, pp. 337–48. Pubmed, doi:10.1007/s11517-021-02459-y. Full Text
Komisarow, Jordan M., et al. “Epidemiology and Outcomes of Acute Respiratory Distress Syndrome Following Isolated Severe Traumatic Brain Injury.” J Intensive Care Med, vol. 37, no. 1, Jan. 2022, pp. 68–74. Pubmed, doi:10.1177/0885066620972001. Full Text Open Access Copy
Vestal, Mark L., et al. “Andexanet alfa and four-factor prothrombin complex concentrate for reversal of apixaban and rivaroxaban in patients diagnosed with intracranial hemorrhage.” J Thromb Thrombolysis, vol. 53, no. 1, Jan. 2022, pp. 167–75. Pubmed, doi:10.1007/s11239-021-02495-3. Full Text
Toro, Camilo, et al. “Association of Brain Injury Biomarkers and Circulatory Shock Following Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.” J Neurosurg Anesthesiol, Dec. 2021. Pubmed, doi:10.1097/ANA.0000000000000828. Full Text
Wang, Haichen, et al. “Neuroprotective Pentapeptide, CN-105, Improves Outcomes in Translational Models of Intracerebral Hemorrhage.” Neurocrit Care, vol. 35, no. 2, Oct. 2021, pp. 441–50. Pubmed, doi:10.1007/s12028-020-01184-y. Full Text
Luu, David, et al. “Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury.” Neurocrit Care, vol. 35, no. 2, Oct. 2021, pp. 434–40. Pubmed, doi:10.1007/s12028-020-01183-z. Full Text Open Access Copy
Krishnamoorthy, Vijay, et al. “Association of Early Multiple Organ Dysfunction With Clinical and Functional Outcomes Over the Year Following Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study.” Crit Care Med, vol. 49, no. 10, Oct. 2021, pp. 1769–78. Pubmed, doi:10.1097/CCM.0000000000005055. Full Text
Kang, J. H., et al. “Anticoagulation after Spontaneous Intraparenchymal Hemorrhage in Patients with Mechanical Heart Valves and Concomitant Atrial Fibrillation.” Journal of Neuroanaesthesiology and Critical Care, vol. 8, no. 3, Sept. 2021, pp. 203–07. Scopus, doi:10.1055/s-0041-1735653. Full Text
Kittner, Steven J., et al. “Ethnic and Racial Variation in Intracerebral Hemorrhage Risk Factors and Risk Factor Burden.” Jama Netw Open, vol. 4, no. 8, Aug. 2021, p. e2121921. Pubmed, doi:10.1001/jamanetworkopen.2021.21921. Full Text
Ormseth, Cora, et al. “Racial Variation in Comfort Measures Only Status in Patients with Intracerebral Hemorrhage.” Neurology, vol. 90, LIPPINCOTT WILLIAMS & WILKINS, 2018.
Marini, Sandro, et al. “Comparison of Genetic Ancestry versus Self-Identified Race and Ethnicity as Risk Factor for Intracerebral Hemorrhage.” Stroke, vol. 49, LIPPINCOTT WILLIAMS & WILKINS, 2018.
Ormseth, Cora H., et al. “Racial Variation in Comfort Measures Only Status in Patients With Intracerebral Hemorrhage.” Stroke, vol. 49, LIPPINCOTT WILLIAMS & WILKINS, 2018.
Ding, Dale, et al. “Venous Thromboembolism Complications in Patients with Spontaneous Intracerebral Hemorrhage: A Multicenter Cohort Study.” Journal of Neurosurgery, vol. 126, no. 4, AMER ASSOC NEUROLOGICAL SURGEONS, 2017, pp. A1434–A1434.
Hwang, David, et al. “Factors Considered by Physicians Versus Nurses When Prognosticating Acute Intracerebral Hemorrhage Outcomes.” Neurology, vol. 86, LIPPINCOTT WILLIAMS & WILKINS, 2016.
Hwang, David, et al. “Factors Considered by Physicians Versus Nurses When Prognosticating Acute Intracerebral Hemorrhage Outcomes.” Neurology, vol. 86, 2016.
Chaturvedi, Seemant, et al. “Do Women Receive Less Aggressive Care Following Intracerebral Hemorrhage?.” Stroke, vol. 47, LIPPINCOTT WILLIAMS & WILKINS, 2016.
Lei, Beilei, et al. “Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.” Neuroendocrinology, vol. 103, no. 6, 2016, pp. 665–77. Pubmed, doi:10.1159/000442204. Full Text
Hwang, David Y., et al. “Accurate Outcome Predictions for Intracerebral Hemorrhage Patients Are More Likely Than Inaccurate Predictions to Be Influenced by Co-morbidities Not Included in Clinical Scales.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.
Lord, Aaron S., et al. “The Impact of Fever on Presentation in Intracerebral Hemorrhage: The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study.” Stroke, vol. 46, LIPPINCOTT WILLIAMS & WILKINS, 2015.