Michael Lucas James

Michael Lucas James

Associate Professor of Anesthesiology

External Address: 
5619D Hafs Building, Durham, NC 27710
Internal Office Address: 
Box 3094 Med Ctr, Durham, NC 27710


I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.

After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.

While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.

In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.

Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.

Education & Training

  • M.D., Louisiana State University 1999

Anderson, Christopher D., and Michael L. James. “Survival and independence after intracerebral hemorrhage: Trends and opportunities.Neurology, vol. 90, no. 23, June 2018, pp. 1043–44. Pubmed, doi:10.1212/WNL.0000000000005625. Full Text

Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants, Eike. “Unmet Needs and Challenges in Clinical Research of Intracerebral Hemorrhage.Stroke, vol. 49, no. 5, May 2018, pp. 1299–307. Pubmed, doi:10.1161/STROKEAHA.117.019541. Full Text

Hemorrhagic Stroke Academia Industry (HEADS) Roundtable Participants, Hemorrhagic Stroke Acad Ind. “Basic and Translational Research in Intracerebral Hemorrhage: Limitations, Priorities, and Recommendations.Stroke, vol. 49, no. 5, May 2018, pp. 1308–14. Pubmed, doi:10.1161/STROKEAHA.117.019539. Full Text

Boehme, Amelia K., et al. “Systemic inflammatory response syndrome, infection, and outcome in intracerebral hemorrhage.Neurol Neuroimmunol Neuroinflamm, vol. 5, no. 2, Mar. 2018, p. e428. Pubmed, doi:10.1212/NXI.0000000000000428. Full Text

El Husseini, Nada, et al. “Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.J Stroke Cerebrovasc Dis, vol. 27, no. 1, Jan. 2018, pp. 125–31. Pubmed, doi:10.1016/j.jstrokecerebrovasdis.2017.08.017. Full Text

Marini, Sandro, et al. “Comparison of Genetic and Self-Identified Ancestry in Modeling Intracerebral Hemorrhage Risk.Front Neurol, vol. 9, 2018, p. 514. Pubmed, doi:10.3389/fneur.2018.00514. Full Text

Hwang, David Y., et al. “Factors Considered by Clinicians when Prognosticating Intracerebral Hemorrhage Outcomes.Neurocrit Care, vol. 27, no. 3, Dec. 2017, pp. 316–25. Pubmed, doi:10.1007/s12028-017-0430-7. Full Text

Kidwell, Chelsea S., et al. “Author response: Ischemic Lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage.Neurology, vol. 89, no. 16, Oct. 2017, pp. 1755–56. Pubmed, doi:10.1212/WNL.0000000000004509. Full Text

James, Michael L., et al. “Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.Neurology, vol. 89, no. 10, Sept. 2017, pp. 1011–19. Pubmed, doi:10.1212/WNL.0000000000004255. Full Text

James, M. L., et al. “Gonadal hormone regulation as therapeutic strategy after acute intracerebral hemorrhage.” Proceedings of Singapore Healthcare, vol. 26, no. 3, Sept. 2017, pp. 139–43. Scopus, doi:10.1177/2010105817725081. Full Text