Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Guha, Rahul, et al. “Aggressiveness of care following intracerebral hemorrhage in women and men.” Neurology, vol. 89, no. 4, July 2017, pp. 349–54. Pubmed, doi:10.1212/WNL.0000000000004143. Full Text
Fernando, Kryshani T. M., and Michael James. “Early predictors of rapidly evolving multiple sclerosis: A case report.” J Neuroimmunol, vol. 307, June 2017, pp. 42–46. Pubmed, doi:10.1016/j.jneuroim.2017.03.017. Full Text
Umeano, Odera, et al. “Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury.” World J Crit Care Med, vol. 6, no. 2, May 2017, pp. 107–15. Pubmed, doi:10.5492/wjccm.v6.i2.107. Full Text Open Access Copy
James, Michael L., et al. “Sex and Age Interactions and Differences in Outcomes After Intracerebral Hemorrhage.” J Womens Health (Larchmt), vol. 26, no. 4, Apr. 2017, pp. 380–88. Pubmed, doi:10.1089/jwh.2016.5849. Full Text
Kram, Bridgette, et al. “Analgesia and Sedation Requirements in Mechanically Ventilated Trauma Patients With Acute, Preinjury Use of Cocaine and/or Amphetamines.” Anesth Analg, vol. 124, no. 3, Mar. 2017, pp. 782–88. Pubmed, doi:10.1213/ANE.0000000000001740. Full Text
Kidwell, Chelsea S., et al. “Ischemic lesions, blood pressure dysregulation, and poor outcomes in intracerebral hemorrhage.” Neurology, vol. 88, no. 8, Feb. 2017, pp. 782–88. Pubmed, doi:10.1212/WNL.0000000000003630. Full Text
Lei, Beilei, et al. “Erratum: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage.” Sci Rep, vol. 7, Jan. 2017, p. 39580. Pubmed, doi:10.1038/srep39580. Full Text Open Access Copy
Babi, Marc-Alain, and Michael L. James. “Peri-Hemorrhagic Edema and Secondary Hematoma Expansion after Intracerebral Hemorrhage: From Benchwork to Practical Aspects.” Front Neurol, vol. 8, 2017, p. 4. Pubmed, doi:10.3389/fneur.2017.00004. Full Text
Berger, Miles, et al. “The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.” Front Immunol, vol. 8, 2017, p. 1528. Pubmed, doi:10.3389/fimmu.2017.01528. Full Text
Dhar, Rajat, et al. “The State of Neurocritical Care Fellowship Training and Attitudes toward Accreditation and Certification: A Survey of Neurocritical Care Fellowship Program Directors.” Front Neurol, vol. 8, 2017, p. 548. Pubmed, doi:10.3389/fneur.2017.00548. Full Text