Michael Lucas James

Michael Lucas James

Associate Professor of Anesthesiology

External Address: 
5619D Hafs Building, Durham, NC 27710
Internal Office Address: 
Box 3094 Med Ctr, Durham, NC 27710


I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.

After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.

While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.

In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.

Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.

Education & Training

  • M.D., Louisiana State University 1999

Babi, Marc-Alain, and Michael L. James. “Spontaneous Intracerebral Hemorrhage: Should We Operate?Front Neurol, vol. 8, 2017, p. 645. Pubmed, doi:10.3389/fneur.2017.00645. Full Text

Crespo, Veronica, and Michael L. Luke James. “Neuromuscular Disease in the Neurointensive Care Unit.Anesthesiol Clin, vol. 34, no. 3, Sept. 2016, pp. 601–19. Pubmed, doi:10.1016/j.anclin.2016.04.010. Full Text

Kofke, W. Andrew, et al. “Update in Neuroanesthesia-An Anesthesiology Clinics Issue Affiliated with SNACC.Anesthesiol Clin, vol. 34, no. 3, Sept. 2016, pp. xv–xvii. Pubmed, doi:10.1016/j.anclin.2016.06.013. Full Text

Koch, Sebastian, et al. “Racial-ethnic disparities in acute blood pressure after intracerebral hemorrhage.Neurology, vol. 87, no. 8, Aug. 2016, pp. 786–91. Pubmed, doi:10.1212/WNL.0000000000002962. Full Text

Woo, Daniel, and Michael L. James. “Sex differences exist after intracerebral hemorrhage but may not affect outcome.Neurology, vol. 87, no. 3, July 2016, p. 244. Pubmed, doi:10.1212/WNL.0000000000002794. Full Text

Berger, Miles, et al. “The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.J Alzheimers Dis, vol. 52, no. 4, Apr. 2016, pp. 1299–310. Pubmed, doi:10.3233/JAD-151190. Full Text Open Access Copy

Woo, Daniel, et al. “Incontinence and gait disturbance after intraventricular extension of intracerebral hemorrhage.Neurology, vol. 86, no. 10, Mar. 2016, pp. 905–11. Pubmed, doi:10.1212/WNL.0000000000002449. Full Text Open Access Copy

Hwang, David Y., et al. “Clinician judgment vs formal scales for predicting intracerebral hemorrhage outcomes.Neurology, vol. 86, no. 2, Jan. 2016, pp. 126–33. Pubmed, doi:10.1212/WNL.0000000000002266. Full Text Open Access Copy

Traylor, Matthew, et al. “Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.Neurology, vol. 86, no. 2, Jan. 2016, pp. 146–53. Pubmed, doi:10.1212/WNL.0000000000002263. Full Text Open Access Copy