Michael Lucas James
Associate Professor of Anesthesiology
I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.
After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.
While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.
In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.
Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.
Hsieh, Justin T., et al. “Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage.” Neuroendocrinology, vol. 103, no. 5, 2016, pp. 518–30. Pubmed, doi:10.1159/000440883. Full Text Open Access Copy
Walsh, Kyle B., et al. “Monocyte Count and 30-Day Case Fatality in Intracerebral Hemorrhage.” Stroke, vol. 46, no. 8, Aug. 2015, pp. 2302–04. Pubmed, doi:10.1161/STROKEAHA.115.009880. Full Text
Coull, B., et al. “An analysis of cerebral amyloid angiopathy by the Boston Criteria in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) cohort.” International Journal of Stroke, vol. 10, WILEY-BLACKWELL, Apr. 2015, pp. 290–91.
Gokhale, Sankalp, et al. “Sex differences in incidence, pathophysiology, and outcome of primary intracerebral hemorrhage.” Stroke, vol. 46, no. 3, Mar. 2015, pp. 886–92. Pubmed, doi:10.1161/STROKEAHA.114.007682. Full Text
Battey, Thomas W. K., et al. “Recommendations from the international stroke genetics consortium, part 2: biological sample collection and storage.” Stroke, vol. 46, no. 1, Jan. 2015, pp. 285–90. Pubmed, doi:10.1161/STROKEAHA.114.006851. Full Text
Feix, James A., et al. “Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.” Springerplus, vol. 4, 2015, p. 350. Pubmed, doi:10.1186/s40064-015-1126-0. Full Text Open Access Copy
Warner, David S., et al. “Translational research in acute central nervous system injury: lessons learned and the future.” Jama Neurol, vol. 71, no. 10, Oct. 2014, pp. 1311–18. Pubmed, doi:10.1001/jamaneurol.2014.1238. Full Text
Olson, DaiWai M., et al. “Exploring the impact of augmenting sedation assessment with physiologic monitors.” Aust Crit Care, vol. 27, no. 3, Aug. 2014, pp. 145–50. Pubmed, doi:10.1016/j.aucc.2013.09.001. Full Text
Lei, Beilei, et al. “Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage.” J Vis Exp, no. 89, July 2014. Pubmed, doi:10.3791/51439. Full Text Open Access Copy