Michael Lucas James

Michael Lucas James

Associate Professor of Anesthesiology

External Address: 
5619D Hafs Building, Durham, NC 27710
Internal Office Address: 
Box 3094 Med Ctr, Durham, NC 27710


I have an extensive background in neuroanesthesia and neurointensive care and a special research interest in translational and clinical research aspects of intracerebral hemorrhage.

After completing residencies in neurology and anesthesiology with fellowships in neurocritical care, neuroanesthesia, and vascular neurology, I developed a murine model of intracerebral hemorrhage in the Multidisciplinary Neuroprotection Laboratories at Duke University. After optimization of the model, I have begun to pursue translatable mechanisms of modifying neuroinflammation after intracerebral hemorrhage to improve long-term functional recovery. In addition, I have used the model to evaluate the potential of several novel therapeutics for translation into human clinical trials.

While maintaining an active and productive laboratory, I am or have been a Principal Investigator on several clinical trials involving patients with intracerebral hemorrhage. As part of the Translational Acute Brain Injury Research Center at Duke University, I am, or have been, the Duke site-PI for large, multicenter trials funded by the NIH, including CLEAR-IVH, MISTIE, ERICH, and HI-Def studies. Further, I am leading smaller industry-sponsored trials and “home grown” projects in this patient population.

In addition to a research focus in intracerebral hemorrhage, I have an active clinical practice in neuroanesthesia. Our center consistently handles a high volume of neurovascular neurosurgical cases, which require neuroanesthesia subspecialization. This small group of neuroanesthesiologists handles patient care and research opportunities during the peri-operative period, as patients move between the emergency department, neurointensive care unit, operative suites, and neurointerventional suites. I am, or have been, Co-PI of several small, industry-sponsored neuroanesthesia device or therapeutic clinical trials.

Finally, I am fortunate to be part of a unique team of highly motivated and productive individuals that comprise a truly translational collaboration. This allows me to propel ideas from bench to bedside and the ability to reverse translate ideas from the bedside back to the bench. In summary, I have a demonstrated record of successful and productive research projects in areas of high relevance to intracerebral hemmorrhage.

Education & Training

  • M.D., Louisiana State University 1999

Hsieh, Justin T., et al. “Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage.Neuroendocrinology, vol. 103, no. 5, 2016, pp. 518–30. Pubmed, doi:10.1159/000440883. Full Text Open Access Copy

Walsh, Kyle B., et al. “Monocyte Count and 30-Day Case Fatality in Intracerebral Hemorrhage.Stroke, vol. 46, no. 8, Aug. 2015, pp. 2302–04. Pubmed, doi:10.1161/STROKEAHA.115.009880. Full Text

Coull, B., et al. “An analysis of cerebral amyloid angiopathy by the Boston Criteria in the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) cohort.” International Journal of Stroke, vol. 10, WILEY-BLACKWELL, Apr. 2015, pp. 290–91.

Gokhale, Sankalp, et al. “Sex differences in incidence, pathophysiology, and outcome of primary intracerebral hemorrhage.Stroke, vol. 46, no. 3, Mar. 2015, pp. 886–92. Pubmed, doi:10.1161/STROKEAHA.114.007682. Full Text

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Guercio, Jason R., et al. “Anesthesia for interventional neuroradiology.Int Anesthesiol Clin, vol. 53, no. 1, 2015, pp. 87–106. Pubmed, doi:10.1097/AIA.0000000000000044. Full Text

Feix, James A., et al. “Intra-operative hydroxyethyl starch is not associated with post-craniotomy hemorrhage.Springerplus, vol. 4, 2015, p. 350. Pubmed, doi:10.1186/s40064-015-1126-0. Full Text Open Access Copy

Warner, David S., et al. “Translational research in acute central nervous system injury: lessons learned and the future.Jama Neurol, vol. 71, no. 10, Oct. 2014, pp. 1311–18. Pubmed, doi:10.1001/jamaneurol.2014.1238. Full Text

Olson, DaiWai M., et al. “Exploring the impact of augmenting sedation assessment with physiologic monitors.Aust Crit Care, vol. 27, no. 3, Aug. 2014, pp. 145–50. Pubmed, doi:10.1016/j.aucc.2013.09.001. Full Text