Associate Professor of Anesthesiology
My research team focuses on understanding the cause of postoperative cognitive dysfunction (POCD) and delirium, and whether these disorders are caused by perioperative changes in Alzheimer's disease pathways. We are also interested in whether delirium or POCD are associated with an increased long term risk of developing Alzheimer's disease. Towards these ends, we use a combination of methods including cognitive testing, CSF and blood sampling, functional neuroimaging, and rigorous biochemical assays. This work has the potential to improve long term outcomes for the more than 16 million Americans over age 60 who undergo anesthesia and surgery each year.
Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Mentor). 1996 to 2026
Geroscience signaling metabolites NAD+ and beta-hydroxybutyrate modulating acute neuroinflammation in delirium awarded by Buck Institute for Research on Aging (Principal Investigator). 2020 to 2025
Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health (Collaborator). 2019 to 2025
Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)" awarded by National Institutes of Health (Preceptor). 2020 to 2023
The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by National Institutes of Health (Mentor). 2021 to 2023
The Role of MCP1 and monocyte activation within the Central Nervous System in Human Postoperative Cognitive Dysfunction and Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Principal Investigator). 2016 to 2022
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health (Investigator). 2017 to 2022
Proteomic Determination of APOE4-induced Neuroinflammation in the Pathogenesis of Alzheimer's Disease awarded by Ruth K. Broad Biomedical Research Foundation (Principal Investigator). 2020 to 2022
A High-Performance 3T MRI for Brain Imaging awarded by National Institutes of Health (Minor User). 2021 to 2022
Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Collaborator). 2017 to 2022
Doshi, A., et al. “Geriatric anesthesia: Age-dependent changes in the central and peripheral nervous systems.” Geriatric Anesthesiology: Third Edition, 2017, pp. 145–60. Scopus, doi:10.1007/978-3-319-66878-9_10. Full Text
Berger, M., and B. Roth. “Pharmacology of serotonergic and central adrenergic neurotransmission.” Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition, 2012, pp. 481–519.
Meier, Jennie, et al. “Racial and Ethnic Disparities in Access to Local Anesthesia for Inguinal Hernia Repair.” J Surg Res, vol. 266, Oct. 2021, pp. 366–72. Pubmed, doi:10.1016/j.jss.2021.04.026. Full Text
Meier, Jennie, et al. “Local Anesthesia is Associated with Fewer Complications in Umbilical Hernia Repair in Frail Veterans.” J Surg Res, vol. 266, Oct. 2021, pp. 88–95. Pubmed, doi:10.1016/j.jss.2021.04.006. Full Text
Meier, Jennie, et al. “Using local rather than general anesthesia for inguinal hernia repair may significantly reduce complications for frail Veterans.” Am J Surg, vol. 222, no. 3, Sept. 2021, pp. 619–24. Pubmed, doi:10.1016/j.amjsurg.2021.01.026. Full Text
Devinney, Michael J., and Miles Berger. “Goldilocks and propofol dosage in older adults: Too much, too little, or just right?” J Am Geriatr Soc, vol. 69, no. 8, Aug. 2021, pp. 2106–09. Pubmed, doi:10.1111/jgs.17221. Full Text
Whitson, Heather E., et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.” J Am Geriatr Soc, July 2021. Pubmed, doi:10.1111/jgs.17384. Full Text
Cooter Wright, Mary, et al. “A Processed Electroencephalogram-Based Brain Anesthetic Resistance Index Is Associated With Postoperative Delirium in Older Adults: A Dual Center Study.” Anesth Analg, July 2021. Pubmed, doi:10.1213/ANE.0000000000005660. Full Text
Balentine, Courtney J., et al. “Using local rather than general anesthesia for inguinal hernia repair is associated with shorter operative time and enhanced postoperative recovery.” Am J Surg, vol. 221, no. 5, May 2021, pp. 902–07. Pubmed, doi:10.1016/j.amjsurg.2020.08.024. Full Text
Terrando, Niccolò, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep, vol. 11, no. 1, Feb. 2021, p. 3047. Pubmed, doi:10.1038/s41598-021-82606-5. Full Text
Balentine, Courtney J., et al. “Using Local Anesthesia for Inguinal Hernia Repair Reduces Complications in Older Patients.” J Surg Res, vol. 258, Feb. 2021, pp. 64–72. Pubmed, doi:10.1016/j.jss.2020.08.054. Full Text
Au, S., et al. “Preoperative EEG: A Potential Predictor of Postoperative Delirium in Older Adults.” Journal of the American Geriatrics Society, vol. 69, 2021, pp. S222–23.
Meier, Jennie, et al. “Local Anesthesia Can Reduce Complications in Adults Undergoing Umbilical Hernia Repair.” Journal of the American College of Surgeons, vol. 231, no. 4, 2020, pp. S100–01.
Ha, Christine, et al. “Cognitive and Cerebrospinal fluid Alzheimer's Disease biomarker changes over time in older surgical patients and matched nonsurgical controls.” Anesthesia and Analgesia, vol. 130, 2020, pp. 502–502.
Devinney, Michael, et al. “The SANDMAN Study: Sleep Apnea, Neuroinflammation, and Cognitive Dysfunction Manifesting After Non-cardiac surgery.” Anesthesia and Analgesia, vol. 130, 2020, pp. 514–15.
VanDusen, Keith W., et al. “The MARBLE Study: Modulating ApoE signaling to Reduce Brain inflammation, deLirium, and postopErative Cognitive Dysfunction.” Anesthesia and Analgesia, vol. 130, 2020, pp. 432–33.
Eleswarpu, Sarada, et al. “Developing a Real-time EEG-guided Anesthesia Management curriculum for Educating Residents (DREAMER): A randomized controlled trial.” Anesthesia and Analgesia, vol. 130, 2020, pp. 413–413.
Ha, C., et al. “Postoperative Resilience in Older People: An EEG Complexity Measure Predicts Postoperative Attention Deficits.” Journal of the American Geriatrics Society, vol. 68, WILEY, 2020, pp. S179–S179.
Devinney, Michael, et al. “THE SANDMAN STUDY: SLEEP APNEA, NEUROINFLAMMATION, AND COGNITIVE DYSFUNCTION MANIFESTING AFTER NON-CARDIAC SURGERY.” Anesthesia and Analgesia, vol. 128, 2019, pp. 918–918.
Bunning, Thomas, et al. “THE INTUIT STUDY: INVESTIGATING NEUROINFLAMMATION UNDERLYING POSTOPERATIVE NEUROCOGNITIVE DYSFUNCTION AND DELIRIUM IN OLDER ADULTS.” Anesthesia and Analgesia, vol. 128, 2019, pp. 432–432.
Devinney, Michael, et al. “METABOLIPIDOMIC ANALYSIS OF CEREBROSPINAL FLUID REVEALS INCREASED ARACHIDONIC ACID-DERIVED LIPIDS AND SPECIALIZED PRO-RESOLVING MEDIATORS 24 HRS AND 6-WEEKS FOLLOWING SURGERY AND ANESTHESIA.” Anesthesia and Analgesia, vol. 128, 2019, pp. 485–86.