Miles Berger
Associate Professor of Anesthesiology
Overview
My research team focuses on understanding the cause of postoperative cognitive dysfunction (POCD) and delirium, and whether these disorders are caused by perioperative changes in Alzheimer's disease pathways. We are also interested in whether delirium or POCD are associated with an increased long term risk of developing Alzheimer's disease. Towards these ends, we use a combination of methods including cognitive testing, CSF and blood sampling, functional neuroimaging, and rigorous biochemical assays. This work has the potential to improve long term outcomes for the more than 16 million Americans over age 60 who undergo anesthesia and surgery each year.
Selected Grants
Geroscience signaling metabolites NAD+ and beta-hydroxybutyrate modulating acute neuroinflammation in delirium awarded by Buck Institute for Research on Aging (Principal Investigator). 2020 to 2025
Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health (Collaborator). 2019 to 2024
Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)" awarded by National Institutes of Health (Preceptor). 2020 to 2023
The Role of MCP1 and monocyte activation within the Central Nervous System in Human Postoperative Cognitive Dysfunction and Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Principal Investigator). 2016 to 2022
Proteomic Determination of APOE4-induced Neuroinflammation in the Pathogenesis of Alzheimer's Disease awarded by Ruth K. Broad Biomedical Research Foundation (Principal Investigator). 2020 to 2022
Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Collaborator). 2017 to 2022
Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Principal Investigator). 2017 to 2022
The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Mentor). 2020 to 2021
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health (Investigator). 2017 to 2021
A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health (Collaborator). 2016 to 2021
Pages
Doshi, A., et al. “Geriatric anesthesia: Age-dependent changes in the central and peripheral nervous systems.” Geriatric Anesthesiology: Third Edition, 2017, pp. 145–60. Scopus, doi:10.1007/978-3-319-66878-9_10. Full Text
Berger, M., and B. Roth. “Pharmacology of serotonergic and central adrenergic neurotransmission.” Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition, 2012, pp. 481–519.
Balentine, Courtney J., et al. “Using Local Anesthesia for Inguinal Hernia Repair Reduces Complications in Older Patients.” J Surg Res, vol. 258, Feb. 2021, pp. 64–72. Pubmed, doi:10.1016/j.jss.2020.08.054. Full Text
Meier, Jennie, et al. “Using local rather than general anesthesia for inguinal hernia repair may significantly reduce complications for frail Veterans.” American Journal of Surgery, Jan. 2021. Epmc, doi:10.1016/j.amjsurg.2021.01.026. Full Text
Velkers, Clive, et al. “Association Between Exposure to General Versus Regional Anesthesia and Risk of Dementia in Older Adults.” J Am Geriatr Soc, vol. 69, no. 1, Jan. 2021, pp. 58–67. Pubmed, doi:10.1111/jgs.16834. Full Text
Berger, Miles, et al. “APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.” J Alzheimers Dis, vol. 79, no. 2, 2021, pp. 511–30. Pubmed, doi:10.3233/JAD-200747. Full Text
Oyeyemi, Deborah M., et al. “Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.” J Geriatr Psychiatry Neurol, Dec. 2020, p. 891988720978791. Pubmed, doi:10.1177/0891988720978791. Full Text
Berger, Miles, and Kamrouz Ghadimi. “Necessary Heroes and Ethos, from Fighting Nazis to COVID-19.” Anesthesiology, vol. 133, no. 6, Dec. 2020, pp. 1307–10. Epmc, doi:10.1097/aln.0000000000003488. Full Text
Balentine, Courtney J., et al. “Using local rather than general anesthesia for inguinal hernia repair is associated with shorter operative time and enhanced postoperative recovery.” Am J Surg, Aug. 2020. Pubmed, doi:10.1016/j.amjsurg.2020.08.024. Full Text
Vasunilashorn, Sarinnapha M., et al. “A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM).” J Am Geriatr Soc, vol. 68, no. 8, Aug. 2020, pp. 1874–76. Pubmed, doi:10.1111/jgs.16538. Full Text
Nobuhara, Chloe K., et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol, vol. 267, no. 7, July 2020, pp. 2002–06. Pubmed, doi:10.1007/s00415-020-09797-1. Full Text
Berger, Miles, et al. “Of Parachutes, Speedometers, and EEG: What Evidence Do We Need to Use Devices and Monitors?” Anesth Analg, vol. 130, no. 5, May 2020, pp. 1274–77. Pubmed, doi:10.1213/ANE.0000000000004653. Full Text
Pages
Meier, Jennie, et al. “Local Anesthesia Can Reduce Complications in Adults Undergoing Umbilical Hernia Repair.” Journal of the American College of Surgeons, vol. 231, no. 4, 2020, pp. S100–01.
Ha, C., et al. “Postoperative Resilience in Older People: An EEG Complexity Measure Predicts Postoperative Attention Deficits.” Journal of the American Geriatrics Society, vol. 68, WILEY, 2020, pp. S179–S179.
Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.
Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.
Devinney, Michael, et al. “IS OBSTRUCTIVE SLEEP APNEA ASSOCIATED WITH POSTOPERATIVE DELIRIUM AND COGNITIVE DECLINE?” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 704–05.
Cheong, Yee Ching Vanessa, et al. “PERIOPERATIVE TRAJECTORY OF ALZHEIMER'S DISEASE BIOMARKERS IN SURGICAL PATIENTS AND MATCHED NON-SURGICAL CONTROLS.” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 353–56.
Berger, M., et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S5–S5.
Bottiger, B., et al. “Posterior Reversible Encephalopathy Syndrome After Lung Transplant: Clinical Characteristics and Outcomes.” Journal of Heart and Lung Transplantation, vol. 37, no. 4, ELSEVIER SCIENCE INC, 2018, pp. S252–S252.
Devinney, M. J., et al. “Comparing CAM-ICU and 3D-CAM as early postoperative delirium screening tools.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S172–73.
Berger, M., et al. “INTRAVENOUS IMMUNOGLOBULIN ADMINISTRATION IS ASSOCIATED WITH REDUCED DELIRIUM RATE AND DECREASED DELIRIUM DURATION IN LUNG TRANSPLANT RECIPIENTS- A SINGLE CENTER RETROSPECTIVE STUDY.” Anesthesia and Analgesia, vol. 122, LIPPINCOTT WILLIAMS & WILKINS, 2016.