Miles Berger

Miles Berger

Associate Professor of Anesthesiology

External Address: 
201 Trent Drive, 4317 Duke South, Orange Zone, Durham, NC 27710
Internal Office Address: 
DUMC Box 3094, Durham, NC 27710
Phone: 
919.684.8679

Overview

My research team focuses on understanding the cause of postoperative cognitive dysfunction (POCD) and delirium, and whether these disorders are caused by perioperative changes in Alzheimer's disease pathways. We are also interested in whether delirium or POCD are associated with an increased long term risk of developing Alzheimer's disease. Towards these ends, we use a combination of methods including cognitive testing, CSF and blood sampling, functional neuroimaging, and rigorous biochemical assays. This work has the potential to improve long term outcomes  for the more than 16 million Americans over age 60 who undergo anesthesia and surgery each year.

Education & Training

  • Internship and Residency, Anesthesiology, Duke University School of Medicine 2009 - 2013

  • M.D., University of California - San Francisco 2009

  • Ph.D., University of California - San Francisco 2007

Selected Grants

Geroscience signaling metabolites NAD+ and beta-hydroxybutyrate modulating acute neuroinflammation in delirium awarded by Buck Institute for Research on Aging (Principal Investigator). 2020 to 2025

Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health (Collaborator). 2019 to 2024

The Role of MCP1 and monocyte activation within the Central Nervous System in Human Postoperative Cognitive Dysfunction and Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Principal Investigator). 2016 to 2022

Proteomic Determination of APOE4-induced Neuroinflammation in the Pathogenesis of Alzheimer's Disease awarded by Ruth K. Broad Biomedical Research Foundation (Principal Investigator). 2020 to 2022

Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Collaborator). 2017 to 2022

Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Principal Investigator). 2017 to 2022

The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Mentor). 2020 to 2021

Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health (Investigator). 2017 to 2021

Pages

Doshi, A., et al. “Geriatric anesthesia: Age-dependent changes in the central and peripheral nervous systems.” Geriatric Anesthesiology: Third Edition, 2017, pp. 145–60. Scopus, doi:10.1007/978-3-319-66878-9_10. Full Text

Berger, M., and B. Roth. “Pharmacology of serotonergic and central adrenergic neurotransmission.” Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition, 2012, pp. 481–519.

Balentine, Courtney J., et al. “Using Local Anesthesia for Inguinal Hernia Repair Reduces Complications in Older Patients.J Surg Res, vol. 258, Feb. 2021, pp. 64–72. Pubmed, doi:10.1016/j.jss.2020.08.054. Full Text

Meier, Jennie, et al. “Using local rather than general anesthesia for inguinal hernia repair may significantly reduce complications for frail Veterans.American Journal of Surgery, Jan. 2021. Epmc, doi:10.1016/j.amjsurg.2021.01.026. Full Text

Velkers, Clive, et al. “Association Between Exposure to General Versus Regional Anesthesia and Risk of Dementia in Older Adults.J Am Geriatr Soc, vol. 69, no. 1, Jan. 2021, pp. 58–67. Pubmed, doi:10.1111/jgs.16834. Full Text

Berger, Miles, et al. “APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.J Alzheimers Dis, vol. 79, no. 2, 2021, pp. 511–30. Pubmed, doi:10.3233/JAD-200747. Full Text

Oyeyemi, Deborah M., et al. “Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.J Geriatr Psychiatry Neurol, Dec. 2020, p. 891988720978791. Pubmed, doi:10.1177/0891988720978791. Full Text

Berger, Miles, and Kamrouz Ghadimi. “Necessary Heroes and Ethos, from Fighting Nazis to COVID-19.Anesthesiology, vol. 133, no. 6, Dec. 2020, pp. 1307–10. Epmc, doi:10.1097/aln.0000000000003488. Full Text

Vasunilashorn, Sarinnapha M., et al. “A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM).J Am Geriatr Soc, vol. 68, no. 8, Aug. 2020, pp. 1874–76. Pubmed, doi:10.1111/jgs.16538. Full Text

Nobuhara, Chloe K., et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.J Neurol, vol. 267, no. 7, July 2020, pp. 2002–06. Pubmed, doi:10.1007/s00415-020-09797-1. Full Text

Berger, Miles, et al. “Of Parachutes, Speedometers, and EEG: What Evidence Do We Need to Use Devices and Monitors?Anesth Analg, vol. 130, no. 5, May 2020, pp. 1274–77. Pubmed, doi:10.1213/ANE.0000000000004653. Full Text

Pages

Meier, Jennie, et al. “Local Anesthesia Can Reduce Complications in Adults Undergoing Umbilical Hernia Repair.” Journal of the American College of Surgeons, vol. 231, no. 4, 2020, pp. S100–01.

Ha, C., et al. “Postoperative Resilience in Older People: An EEG Complexity Measure Predicts Postoperative Attention Deficits.” Journal of the American Geriatrics Society, vol. 68, WILEY, 2020, pp. S179–S179.

Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.

Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.

Berger, M., et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S5–S5.

Bottiger, B., et al. “Posterior Reversible Encephalopathy Syndrome After Lung Transplant: Clinical Characteristics and Outcomes.” Journal of Heart and Lung Transplantation, vol. 37, no. 4, ELSEVIER SCIENCE INC, 2018, pp. S252–S252.

Devinney, M. J., et al. “Comparing CAM-ICU and 3D-CAM as early postoperative delirium screening tools.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S172–73.

Devinney, Michael, et al. “IS OBSTRUCTIVE SLEEP APNEA ASSOCIATED WITH POSTOPERATIVE DELIRIUM AND COGNITIVE DECLINE?Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 704–05.

Cheong, Yee Ching Vanessa, et al. “PERIOPERATIVE TRAJECTORY OF ALZHEIMER'S DISEASE BIOMARKERS IN SURGICAL PATIENTS AND MATCHED NON-SURGICAL CONTROLS.” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 353–56.

Pages