Miles Berger
Associate Professor of Anesthesiology
Overview
My research team focuses on understanding the cause of postoperative cognitive dysfunction (POCD) and delirium, and whether these disorders are caused by perioperative changes in Alzheimer's disease pathways. We are also interested in whether delirium or POCD are associated with an increased long term risk of developing Alzheimer's disease. Towards these ends, we use a combination of methods including cognitive testing, CSF and blood sampling, functional neuroimaging, and rigorous biochemical assays. This work has the potential to improve long term outcomes for the more than 16 million Americans over age 60 who undergo anesthesia and surgery each year.
Selected Grants
Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health (Collaborator). 2019 to 2024
Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)" awarded by National Institutes of Health (Preceptor). 2020 to 2023
The Role of MCP1 and monocyte activation within the Central Nervous System in Human Postoperative Cognitive Dysfunction and Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Principal Investigator). 2016 to 2022
Proteomic Determination of APOE4-induced Neuroinflammation in the Pathogenesis of Alzheimer's Disease awarded by Ruth K. Broad Biomedical Research Foundation (Principal Investigator). 2020 to 2022
Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Collaborator). 2017 to 2022
Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Principal Investigator). 2017 to 2022
The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Mentor). 2020 to 2021
Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health (Investigator). 2017 to 2021
A Systems Biology Approach to HIV-associated Neurocognitive Impairment: Role of Drug Abuse and Neuroinflammation awarded by National Institutes of Health (Collaborator). 2016 to 2021
A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation (Principal Investigator). 2018 to 2021
Pages
Doshi, A., et al. “Geriatric anesthesia: Age-dependent changes in the central and peripheral nervous systems.” Geriatric Anesthesiology: Third Edition, 2017, pp. 145–60. Scopus, doi:10.1007/978-3-319-66878-9_10. Full Text
Berger, M., and B. Roth. “Pharmacology of serotonergic and central adrenergic neurotransmission.” Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition, 2012, pp. 481–519.
Balentine, Courtney J., et al. “Using local rather than general anesthesia for inguinal hernia repair is associated with shorter operative time and enhanced postoperative recovery.” American Journal of Surgery, Aug. 2020. Epmc, doi:10.1016/j.amjsurg.2020.08.024. Full Text
Vasunilashorn, Sarinnapha M., et al. “A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM).” J Am Geriatr Soc, vol. 68, no. 8, Aug. 2020, pp. 1874–76. Pubmed, doi:10.1111/jgs.16538. Full Text
Berger, Miles, and Kamrouz Ghadimi. “Necessary Heroes and Ethos, from Fighting Nazis to COVID-19.” Anesthesiology, July 2020. Pubmed, doi:10.1097/ALN.0000000000003488. Full Text
Nobuhara, Chloe K., et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol, vol. 267, no. 7, July 2020, pp. 2002–06. Pubmed, doi:10.1007/s00415-020-09797-1. Full Text
Klinger, Rebecca Y., et al. “A Plague on Both Your Monitors! Are Bispectral Index and Cerebral Oximetry Useful for Reducing Postoperative Cognitive Impairment?” J Cardiothorac Vasc Anesth, vol. 34, no. 5, May 2020, pp. 1182–83. Pubmed, doi:10.1053/j.jvca.2020.01.001. Full Text
Berger, Miles, et al. “Of Parachutes, Speedometers, and EEG: What Evidence Do We Need to Use Devices and Monitors?” Anesth Analg, vol. 130, no. 5, May 2020, pp. 1274–77. Pubmed, doi:10.1213/ANE.0000000000004653. Full Text
Wang, Ping, et al. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimers Dement, vol. 16, no. 5, May 2020, pp. 734–49. Pubmed, doi:10.1002/alz.12064. Full Text
Berger, Miles, et al. “Response to 'Correlation between bispectral index and age-adjusted minimal alveolar concentration' (Br J Anaesth 2020; 124:e8).” Br J Anaesth, vol. 124, no. 3, Mar. 2020, pp. e38–39. Pubmed, doi:10.1016/j.bja.2019.12.005. Full Text
VanDusen, Keith W., et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis, vol. 75, no. 4, 2020, pp. 1319–28. Pubmed, doi:10.3233/JAD-191185. Full Text Open Access Copy
Cooter, Mary, et al. “Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis.” Br J Anaesth, vol. 124, no. 1, Jan. 2020, pp. e4–7. Pubmed, doi:10.1016/j.bja.2019.09.036. Full Text
Pages
Ha, C., et al. “Postoperative Resilience in Older People: An EEG Complexity Measure Predicts Postoperative Attention Deficits.” Journal of the American Geriatrics Society, vol. 68, WILEY, 2020, pp. S179–S179.
Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.
Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.
Devinney, Michael, et al. “IS OBSTRUCTIVE SLEEP APNEA ASSOCIATED WITH POSTOPERATIVE DELIRIUM AND COGNITIVE DECLINE?” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 704–05.
Cheong, Yee Ching Vanessa, et al. “PERIOPERATIVE TRAJECTORY OF ALZHEIMER'S DISEASE BIOMARKERS IN SURGICAL PATIENTS AND MATCHED NON-SURGICAL CONTROLS.” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 353–56.
Berger, M., et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S5–S5.
Bottiger, B., et al. “Posterior Reversible Encephalopathy Syndrome After Lung Transplant: Clinical Characteristics and Outcomes.” Journal of Heart and Lung Transplantation, vol. 37, no. 4, ELSEVIER SCIENCE INC, 2018, pp. S252–S252.
Devinney, M. J., et al. “Comparing CAM-ICU and 3D-CAM as early postoperative delirium screening tools.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S172–73.
Raghunathan, K., et al. “ACUTE KIDNEY INJURY AFTER CARDIAC SURGERY AMONG PATIENTS WITH AND WITHOUT PREEXISTING CHRONIC KIDNEY DISEASE: EFFECTS OF PERIOPERATIVE CRYSTALLOID CHOICE.” Anesthesia and Analgesia, vol. 122, LIPPINCOTT WILLIAMS & WILKINS, 2016.
Berger, M., et al. “AGE DEPENDENT TRENDS IN ANESTHETIC ADMINISTRATION, AND THE AGE DEPENDENT DECREASE IN MAC: A SINGLE CENTER RETROSPECTIVE STUDY AND REGRESSION ANALYSIS OF PUBLISHED STUDIES.” Anesthesia and Analgesia, vol. 122, LIPPINCOTT WILLIAMS & WILKINS, 2016.