Miles Berger

Miles Berger

Assistant Professor of Anesthesiology

External Address: 
201 Trent Drive, 4317 Duke South, Orange Zone, Durham, NC 27710
Internal Office Address: 
DUMC Box 3094, Durham, NC 27710
Phone: 
919.684.8679

Overview

My research team focuses on understanding the cause of postoperative cognitive dysfunction (POCD) and delirium, and whether these disorders are caused by perioperative changes in Alzheimer's disease pathways. We are also interested in whether delirium or POCD are associated with an increased long term risk of developing Alzheimer's disease. Towards these ends, we use a combination of methods including cognitive testing, CSF and blood sampling, functional neuroimaging, and rigorous biochemical assays. This work has the potential to improve long term outcomes  for the more than 16 million Americans over age 60 who undergo anesthesia and surgery each year.

Education & Training

  • Internship and Residency, Anesthesiology, Duke University School of Medicine 2009 - 2013

  • M.D., University of California, San Francisco 2009

  • Ph.D., University of California, San Francisco 2007

Selected Grants

Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health (Collaborator). 2019 to 2024

Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative awarded by National Institutes of Health (Investigator). 2017 to 2022

Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Collaborator). 2017 to 2022

Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Principal Investigator). 2017 to 2022

2015 Dennis W. Jahnigen Career Development/GEMSSTAR Program awarded by (Principal Investigator). 2015 to 2020

Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative awarded by National Institutes of Health (Collaborator). 2017 to 2020

The Role of Obstructive Sleep Apnea in Neuroinflammation and Postoperative Cognitive Dysfunction awarded by Foundation for Anesthesia Education and Research (Mentor). 2019

Pages

Doshi, A., et al. “Geriatric anesthesia: Age-dependent changes in the central and peripheral nervous systems.” Geriatric Anesthesiology: Third Edition, 2017, pp. 145–60. Scopus, doi:10.1007/978-3-319-66878-9_10. Full Text

Berger, M., and B. Roth. “Pharmacology of serotonergic and central adrenergic neurotransmission.” Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition, 2012, pp. 481–519.

Mahanna-Gabrielli, Elizabeth, et al. “State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018..” Br J Anaesth, vol. 123, no. 4, Oct. 2019, pp. 464–78. Pubmed, doi:10.1016/j.bja.2019.07.004. Full Text Open Access Copy

Ni, Katherine, et al. “Paradox of age: older patients receive higher age-adjusted minimum alveolar concentration fractions of volatile anaesthetics yet display higher bispectral index values..” Br J Anaesth, vol. 123, no. 3, Sept. 2019, pp. 288–97. Pubmed, doi:10.1016/j.bja.2019.05.040. Full Text

Berger, Miles, et al. “In Response..” Anesth Analg, vol. 129, no. 3, Sept. 2019, pp. e112–13. Pubmed, doi:10.1213/ANE.0000000000004300. Full Text

Carpenter, Christopher R., et al. “Impact of Cognitive Impairment Across Specialties: Summary of a Report From the U13 Conference Series..” J Am Geriatr Soc, Aug. 2019. Pubmed, doi:10.1111/jgs.16093. Full Text

Berger, Miles, et al. “In Response..” Anesth Analg, July 2019. Pubmed, doi:10.1213/ANE.0000000000004300. Full Text

Klinger, Rebecca Y., et al. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial..” Anesthesiology, vol. 130, no. 6, June 2019, pp. 958–70. Pubmed, doi:10.1097/ALN.0000000000002668. Full Text

Berger, Miles, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction..” J Am Geriatr Soc, vol. 67, no. 4, Apr. 2019, pp. 794–98. Pubmed, doi:10.1111/jgs.15770. Full Text Open Access Copy

Yang, T., et al. “Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders..” Br J Anaesth, vol. 122, no. 3, Mar. 2019, pp. 350–60. Pubmed, doi:10.1016/j.bja.2018.10.062. Full Text

Brinkley, Tina E., et al. “Corrigendum to: Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions..” J Gerontol a Biol Sci Med Sci, vol. 74, no. 3, Feb. 2019. Pubmed, doi:10.1093/gerona/gly156. Full Text

Pages

Devinney, M. J., et al. “The Association of Obstructive Sleep Apnea Risk with Postoperative Cognitive Decline.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S178–S178.

Oyeyemi, D., et al. “Depression, Anxiety and Postoperative Cognition in Older Adults.” Journal of the American Geriatrics Society, vol. 67, WILEY, 2019, pp. S338–S338.

Devinney, Michael, et al. “IS OBSTRUCTIVE SLEEP APNEA ASSOCIATED WITH POSTOPERATIVE DELIRIUM AND COGNITIVE DECLINE?.” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 704–05.

Cheong, Yee Ching Vanessa, et al. “PERIOPERATIVE TRAJECTORY OF ALZHEIMER'S DISEASE BIOMARKERS IN SURGICAL PATIENTS AND MATCHED NON-SURGICAL CONTROLS.” Anesthesia and Analgesia, vol. 126, no. 4, LIPPINCOTT WILLIAMS & WILKINS, 2018, pp. 353–56.

Berger, M., et al. “Postoperative Changes in CSF AD Markers, Cognition, and fMRI activity.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S5–S5.

Bottiger, B., et al. “Posterior Reversible Encephalopathy Syndrome After Lung Transplant: Clinical Characteristics and Outcomes.” Journal of Heart and Lung Transplantation, vol. 37, no. 4, ELSEVIER SCIENCE INC, 2018, pp. S252–S252.

Devinney, M. J., et al. “Comparing CAM-ICU and 3D-CAM as early postoperative delirium screening tools.” Journal of the American Geriatrics Society, vol. 66, WILEY, 2018, pp. S172–73.

Raghunathan, K., et al. “ACUTE KIDNEY INJURY AFTER CARDIAC SURGERY AMONG PATIENTS WITH AND WITHOUT PREEXISTING CHRONIC KIDNEY DISEASE: EFFECTS OF PERIOPERATIVE CRYSTALLOID CHOICE.” Anesthesia and Analgesia, vol. 122, LIPPINCOTT WILLIAMS & WILKINS, 2016.

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