Miles Berger

Miles Berger

Associate Professor of Anesthesiology

External Address: 
201 Trent Drive, 4317 Duke South, Orange Zone, Durham, NC 27710
Internal Office Address: 
DUMC Box 3094, Durham, NC 27710
Phone: 
919.684.8679

Overview

My research team focuses on understanding the cause of postoperative cognitive dysfunction (POCD) and delirium, and whether these disorders are caused by perioperative changes in Alzheimer's disease pathways. We are also interested in whether delirium or POCD are associated with an increased long term risk of developing Alzheimer's disease. Towards these ends, we use a combination of methods including cognitive testing, CSF and blood sampling, functional neuroimaging, and rigorous biochemical assays. This work has the potential to improve long term outcomes  for the more than 16 million Americans over age 60 who undergo anesthesia and surgery each year.

Education & Training

  • Internship and Residency, Anesthesiology, Duke University School of Medicine 2009 - 2013

  • M.D., University of California - San Francisco 2009

  • Ph.D., University of California - San Francisco 2007

Selected Grants

Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Mentor). 1996 to 2026

Geroscience signaling metabolites NAD+ and beta-hydroxybutyrate modulating acute neuroinflammation in delirium awarded by Buck Institute for Research on Aging (Principal Investigator). 2020 to 2025

Pathogenesis of Neuroinflammation and Neurocognitive Impairment In HIV-infected Young Adult Cannabis Users awarded by National Institutes of Health (Collaborator). 2019 to 2025

The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by National Institutes of Health (Mentor). 2021 to 2023

The Role of MCP1 and monocyte activation within the Central Nervous System in Human Postoperative Cognitive Dysfunction and Delirium awarded by Society for Neuroscience in Anesthesiology and Critical Care (Principal Investigator). 2016 to 2022

Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health (Investigator). 2017 to 2022

Proteomic Determination of APOE4-induced Neuroinflammation in the Pathogenesis of Alzheimer's Disease awarded by Ruth K. Broad Biomedical Research Foundation (Principal Investigator). 2020 to 2022

A High-Performance 3T MRI for Brain Imaging awarded by National Institutes of Health (Minor User). 2021 to 2022

Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Collaborator). 2017 to 2022

Pages

Doshi, A., et al. “Geriatric anesthesia: Age-dependent changes in the central and peripheral nervous systems.” Geriatric Anesthesiology: Third Edition, 2017, pp. 145–60. Scopus, doi:10.1007/978-3-319-66878-9_10. Full Text

Berger, M., and B. Roth. “Pharmacology of serotonergic and central adrenergic neurotransmission.” Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy: Third Edition, 2012, pp. 481–519.

Meier, Jennie, et al. “Racial and Ethnic Disparities in Access to Local Anesthesia for Inguinal Hernia Repair.J Surg Res, vol. 266, Oct. 2021, pp. 366–72. Pubmed, doi:10.1016/j.jss.2021.04.026. Full Text

Meier, Jennie, et al. “Local Anesthesia is Associated with Fewer Complications in Umbilical Hernia Repair in Frail Veterans.J Surg Res, vol. 266, Oct. 2021, pp. 88–95. Pubmed, doi:10.1016/j.jss.2021.04.006. Full Text

Meier, Jennie, et al. “Using local rather than general anesthesia for inguinal hernia repair may significantly reduce complications for frail Veterans.Am J Surg, vol. 222, no. 3, Sept. 2021, pp. 619–24. Pubmed, doi:10.1016/j.amjsurg.2021.01.026. Full Text

Devinney, Michael J., and Miles Berger. “Goldilocks and propofol dosage in older adults: Too much, too little, or just right?J Am Geriatr Soc, vol. 69, no. 8, Aug. 2021, pp. 2106–09. Pubmed, doi:10.1111/jgs.17221. Full Text

Whitson, Heather E., et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.J Am Geriatr Soc, July 2021. Pubmed, doi:10.1111/jgs.17384. Full Text

Balentine, Courtney J., et al. “Using local rather than general anesthesia for inguinal hernia repair is associated with shorter operative time and enhanced postoperative recovery.Am J Surg, vol. 221, no. 5, May 2021, pp. 902–07. Pubmed, doi:10.1016/j.amjsurg.2020.08.024. Full Text

Nobuhara, Chloe Kimi, and Miles Berger. “Risk of Spinal Hematoma After Lumbar Puncture.Jama, vol. 325, no. 8, Feb. 2021, pp. 787–88. Pubmed, doi:10.1001/jama.2020.24601. Full Text Open Access Copy

Terrando, Niccolò, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.Sci Rep, vol. 11, no. 1, Feb. 2021, p. 3047. Pubmed, doi:10.1038/s41598-021-82606-5. Full Text

Balentine, Courtney J., et al. “Using Local Anesthesia for Inguinal Hernia Repair Reduces Complications in Older Patients.J Surg Res, vol. 258, Feb. 2021, pp. 64–72. Pubmed, doi:10.1016/j.jss.2020.08.054. Full Text

Pages

Au, S., et al. “Preoperative EEG: A Potential Predictor of Postoperative Delirium in Older Adults.” Journal of the American Geriatrics Society, vol. 69, 2021, pp. S222–23.

Meier, Jennie, et al. “Local Anesthesia Can Reduce Complications in Adults Undergoing Umbilical Hernia Repair.” Journal of the American College of Surgeons, vol. 231, no. 4, 2020, pp. S100–01.

Devinney, Michael, et al. “The SANDMAN Study: Sleep Apnea, Neuroinflammation, and Cognitive Dysfunction Manifesting After Non-cardiac surgery.” Anesthesia and Analgesia, vol. 130, 2020, pp. 514–15.

VanDusen, Keith W., et al. “The MARBLE Study: Modulating ApoE signaling to Reduce Brain inflammation, deLirium, and postopErative Cognitive Dysfunction.” Anesthesia and Analgesia, vol. 130, 2020, pp. 432–33.

Eleswarpu, Sarada, et al. “Developing a Real-time EEG-guided Anesthesia Management curriculum for Educating Residents (DREAMER): A randomized controlled trial.” Anesthesia and Analgesia, vol. 130, 2020, pp. 413–413.

Ha, C., et al. “Postoperative Resilience in Older People: An EEG Complexity Measure Predicts Postoperative Attention Deficits.” Journal of the American Geriatrics Society, vol. 68, WILEY, 2020, pp. S179–S179.

Devinney, Michael, et al. “THE SANDMAN STUDY: SLEEP APNEA, NEUROINFLAMMATION, AND COGNITIVE DYSFUNCTION MANIFESTING AFTER NON-CARDIAC SURGERY.” Anesthesia and Analgesia, vol. 128, 2019, pp. 918–918.

Bunning, Thomas, et al. “THE INTUIT STUDY: INVESTIGATING NEUROINFLAMMATION UNDERLYING POSTOPERATIVE NEUROCOGNITIVE DYSFUNCTION AND DELIRIUM IN OLDER ADULTS.” Anesthesia and Analgesia, vol. 128, 2019, pp. 432–432.

Pages