Niccolò Terrando
Associate Professor in Anesthesiology
Overview
Selected Grants
Protective role of Clec7a/dectin-1 in CNS autoimmunity awarded by National Institutes of Health (Collaborator). 2020 to 2025
Bioelectronic regulation of CNS lymphatic drainage in delirium and AD. awarded by Alzheimer's Association (Principal Investigator). 2019 to 2022
Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Principal Investigator). 2017 to 2022
Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Collaborator). 2017 to 2022
Therapies to protect the blood-brain barrier after surgery awarded by Reservoir Neuroscience, Inc. (Principal Investigator). 2021
TEST THE EFFICACY OF EXALYS EP4 ANTAGONIST TO PREVENT NEUROINFLAMMATION AND DELIRIUM IN A PRECLINICAL MODEL awarded by Exalys Therapeutics, Inc (Principal Investigator). 2020 to 2021
A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation (Co Investigator). 2018 to 2021
Profiling postoperative neuroinflammation in a mouse model of delirium superimposed on Parkinson's disease. awarded by Harvard University (Mentor). 2020 to 2021
Targeting microbially-derived juvenile protective factors to resolve neuroinflammation and delirium awarded by National Institutes of Health (Principal Investigator). 2019 to 2021
Bioelectronic rescue of cognitive impairment after surgery awarded by National Institutes of Health (Principal Investigator). 2018 to 2021
Pages
Miller-Rhodes, Patrick, et al. “This Is Your Brain on (Low) Glucose.” Trends Neurosci, vol. 43, no. 12, Dec. 2020, pp. 933–35. Pubmed, doi:10.1016/j.tins.2020.09.002. Full Text
Yang, Ting, et al. “Neuroinflammation after surgery: from mechanisms to therapeutic targets.” Nature Immunology, vol. 21, no. 11, Nov. 2020, pp. 1319–26. Epmc, doi:10.1038/s41590-020-00812-1. Full Text
Wang, Dian-Shi, et al. “Targeting microglia to mitigate perioperative neurocognitive disorders.” Br J Anaesth, vol. 125, no. 3, Sept. 2020, pp. 229–32. Pubmed, doi:10.1016/j.bja.2020.06.027. Full Text
Wang, Ping, et al. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association, vol. 16, no. 5, May 2020, pp. 734–49. Epmc, doi:10.1002/alz.12064. Full Text
Bassi, Gabriel S., et al. “Anatomical and clinical implications of vagal modulation of the spleen.” Neurosci Biobehav Rev, vol. 112, May 2020, pp. 363–73. Pubmed, doi:10.1016/j.neubiorev.2020.02.011. Full Text
VanDusen, Keith W., et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis, vol. 75, no. 4, 2020, pp. 1319–28. Pubmed, doi:10.3233/JAD-191185. Full Text Open Access Copy
Eckenhoff, Roderic G., et al. “Perioperative Neurocognitive Disorder: State of the Preclinical Science.” Anesthesiology, vol. 132, no. 1, Jan. 2020, pp. 55–68. Pubmed, doi:10.1097/ALN.0000000000002956. Full Text
Miller-Rhodes, Patrick, et al. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.” J Neuroinflammation, vol. 16, no. 1, Oct. 2019, p. 193. Pubmed, doi:10.1186/s12974-019-1582-5. Full Text
Terrando, Niccolò, and David S. Warner. “Xenon for traumatic brain injury: a noble step forward and a wet blanket.” Br J Anaesth, vol. 123, no. 1, July 2019, pp. 9–11. Pubmed, doi:10.1016/j.bja.2019.04.004. Full Text
Klinger, Rebecca Y., et al. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology, vol. 130, no. 6, June 2019, pp. 958–70. Pubmed, doi:10.1097/ALN.0000000000002668. Full Text