Niccolò Terrando

Niccolò Terrando

Associate Professor of Anesthesiology

External Address: 
3 Genome Ct, Msrbiii Room 6144, Durham, NC 27710
Phone: 
919.684.6121

Overview

Education & Training

  • Ph.D., Imperial College London (United Kingdom) 2007

Selected Grants

Cell and Molecular Biology Training Program awarded by National Institutes of Health (Mentor). 2021 to 2026

Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Mentor). 1996 to 2026

Protective role of Clec7a/dectin-1 in CNS autoimmunity awarded by National Institutes of Health (Collaborator). 2020 to 2025

Bioelectronic regulation of CNS lymphatic drainage in delirium and AD. awarded by Alzheimer's Association (Principal Investigator). 2019 to 2023

The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by National Institutes of Health (Advisor). 2021 to 2023

Immunoprofiling postoperative delirium during aging and neurodegeneration awarded by University of Rochester Medical Center (Principal Investigator). 2021 to 2023

Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Principal Investigator). 2017 to 2022

Targeting microbially-derived juvenile protective factors to resolve neuroinflammation and delirium awarded by National Institutes of Health (Principal Investigator). 2019 to 2022

Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Collaborator). 2017 to 2022

TEST THE EFFICACY OF EXALYS EP4 ANTAGONIST TO PREVENT NEUROINFLAMMATION AND DELIRIUM IN A PRECLINICAL MODEL awarded by Exalys Therapeutics, Inc (Principal Investigator). 2020 to 2021

Pages

Terrando, Niccolò, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.Sci Rep, vol. 11, no. 1, Feb. 2021, p. 3047. Pubmed, doi:10.1038/s41598-021-82606-5. Full Text

VanDusen, Keith W., et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.J Alzheimers Dis, vol. 80, no. 3, 2021, pp. 1281–97. Pubmed, doi:10.3233/JAD-201544. Full Text Open Access Copy

Miller-Rhodes, Patrick, et al. “This Is Your Brain on (Low) Glucose.Trends Neurosci, vol. 43, no. 12, Dec. 2020, pp. 933–35. Pubmed, doi:10.1016/j.tins.2020.09.002. Full Text

Yang, Ting, et al. “Neuroinflammation after surgery: from mechanisms to therapeutic targets.Nat Immunol, vol. 21, no. 11, Nov. 2020, pp. 1319–26. Pubmed, doi:10.1038/s41590-020-00812-1. Full Text

Wang, Dian-Shi, et al. “Targeting microglia to mitigate perioperative neurocognitive disorders.Br J Anaesth, vol. 125, no. 3, Sept. 2020, pp. 229–32. Pubmed, doi:10.1016/j.bja.2020.06.027. Full Text

Wang, Ping, et al. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.Alzheimers Dement, vol. 16, no. 5, May 2020, pp. 734–49. Pubmed, doi:10.1002/alz.12064. Full Text

Bassi, Gabriel S., et al. “Anatomical and clinical implications of vagal modulation of the spleen.Neurosci Biobehav Rev, vol. 112, May 2020, pp. 363–73. Pubmed, doi:10.1016/j.neubiorev.2020.02.011. Full Text

Eckenhoff, Roderic G., et al. “Perioperative Neurocognitive Disorder: State of the Preclinical Science.Anesthesiology, vol. 132, no. 1, Jan. 2020, pp. 55–68. Pubmed, doi:10.1097/ALN.0000000000002956. Full Text

VanDusen, Keith W., et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.J Alzheimers Dis, vol. 75, no. 4, 2020, pp. 1319–28. Pubmed, doi:10.3233/JAD-191185. Full Text Open Access Copy

Miller-Rhodes, Patrick, et al. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.J Neuroinflammation, vol. 16, no. 1, Oct. 2019, p. 193. Pubmed, doi:10.1186/s12974-019-1582-5. Full Text

Pages