Niccolò Terrando
Associate Professor of Anesthesiology
Overview
Selected Grants
Cell and Molecular Biology Training Program awarded by National Institutes of Health (Mentor). 2021 to 2026
Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Mentor). 1996 to 2026
Protective role of Clec7a/dectin-1 in CNS autoimmunity awarded by National Institutes of Health (Collaborator). 2020 to 2025
Bioelectronic regulation of CNS lymphatic drainage in delirium and AD. awarded by Alzheimer's Association (Principal Investigator). 2019 to 2023
Immunoprofiling postoperative delirium during aging and neurodegeneration awarded by University of Rochester Medical Center (Principal Investigator). 2021 to 2023
The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by National Institutes of Health (Advisor). 2021 to 2023
Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Principal Investigator). 2017 to 2023
Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Collaborator). 2017 to 2023
A Phase II Study of an ApoE mimetic peptide to reduce Postoperative Delirium, Cognitive Dysfunction after Non-Cardiac Surgery in Older Adults awarded by Alzheimer's Drug Discovery Foundation (Co Investigator). 2018 to 2023
Targeting microbially-derived juvenile protective factors to resolve neuroinflammation and delirium awarded by National Institutes of Health (Principal Investigator). 2019 to 2022
Pages
Miller-Rhodes, Patrick, et al. “URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.” Faseb J, vol. 36, no. 6, June 2022, p. e22343. Pubmed, doi:10.1096/fj.202200184RR. Full Text
Gordon, Marcia N., et al. “Impact of COVID-19 on the Onset and Progression of Alzheimer's Disease and Related Dementias: A Roadmap for Future Research.” Alzheimers Dement, vol. 18, no. 5, May 2022, pp. 1038–46. Pubmed, doi:10.1002/alz.12488. Full Text
Zhang, Zhiquan, et al. “Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.” Front Immunol, vol. 13, 2022, p. 856254. Pubmed, doi:10.3389/fimmu.2022.856254. Full Text
Velagapudi, R., et al. “Percutaneous vagus nerve stimulation modulates glia activity and rescues acute Aβ deposition in a mouse model of delirium superimposed on dementia.” Alzheimer’S &Amp; Dementia : The Journal of the Alzheimer’S Association, vol. 17, Dec. 2021, p. e056571. Scopus, doi:10.1002/alz.056571. Full Text
Miller-Rhodes, Patrick, et al. URMC-099 Prophylaxis Prevents Hippocampal Vascular Vulnerability and Synaptic Damage in an Orthopedic Model of Delirium Superimposed on Dementia. Oct. 2021. Epmc, doi:10.1101/2021.10.04.463042. Full Text
Terrando, Niccolò, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep, vol. 11, no. 1, Feb. 2021, p. 3047. Pubmed, doi:10.1038/s41598-021-82606-5. Full Text Open Access Copy
Maurer, Sara V., et al. “Dietary Choline Protects Against Cognitive Decline After Surgery in Mice.” Front Cell Neurosci, vol. 15, 2021, p. 671506. Pubmed, doi:10.3389/fncel.2021.671506. Full Text
VanDusen, Keith W., et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis, vol. 80, no. 3, 2021, pp. 1281–97. Pubmed, doi:10.3233/JAD-201544. Full Text Open Access Copy
Miller-Rhodes, Patrick, et al. “This Is Your Brain on (Low) Glucose.” Trends Neurosci, vol. 43, no. 12, Dec. 2020, pp. 933–35. Pubmed, doi:10.1016/j.tins.2020.09.002. Full Text
Yang, Ting, et al. “Neuroinflammation after surgery: from mechanisms to therapeutic targets.” Nat Immunol, vol. 21, no. 11, Nov. 2020, pp. 1319–26. Pubmed, doi:10.1038/s41590-020-00812-1. Full Text
Pages
Devinney, Michael, et al. “METABOLIPIDOMIC ANALYSIS OF CEREBROSPINAL FLUID REVEALS INCREASED ARACHIDONIC ACID-DERIVED LIPIDS AND SPECIALIZED PRO-RESOLVING MEDIATORS 24 HRS AND 6-WEEKS FOLLOWING SURGERY AND ANESTHESIA.” Anesthesia and Analgesia, vol. 128, 2019, pp. 485–86.