Niccolò Terrando
Associate Professor of Anesthesiology
Overview
Selected Grants
Cell and Molecular Biology Training Program awarded by National Institutes of Health (Mentor). 2021 to 2026
Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Mentor). 1996 to 2026
Protective role of Clec7a/dectin-1 in CNS autoimmunity awarded by National Institutes of Health (Collaborator). 2020 to 2025
Bioelectronic regulation of CNS lymphatic drainage in delirium and AD. awarded by Alzheimer's Association (Principal Investigator). 2019 to 2023
The Association of Blood-Brain Barrier Breakdown with Sleep Apnea and Postoperative Delirium awarded by National Institutes of Health (Advisor). 2021 to 2023
Immunoprofiling postoperative delirium during aging and neurodegeneration awarded by University of Rochester Medical Center (Principal Investigator). 2021 to 2023
Neurovascular dysfunction in delirium superimposed on dementia awarded by National Institutes of Health (Principal Investigator). 2017 to 2022
Targeting microbially-derived juvenile protective factors to resolve neuroinflammation and delirium awarded by National Institutes of Health (Principal Investigator). 2019 to 2022
Neuro-inflammation in Postoperative Cognitive Dysfunction: CSF and fMRI Studies awarded by National Institutes of Health (Collaborator). 2017 to 2022
TEST THE EFFICACY OF EXALYS EP4 ANTAGONIST TO PREVENT NEUROINFLAMMATION AND DELIRIUM IN A PRECLINICAL MODEL awarded by Exalys Therapeutics, Inc (Principal Investigator). 2020 to 2021
Pages
Terrando, Niccolò, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep, vol. 11, no. 1, Feb. 2021, p. 3047. Pubmed, doi:10.1038/s41598-021-82606-5. Full Text
VanDusen, Keith W., et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis, vol. 80, no. 3, 2021, pp. 1281–97. Pubmed, doi:10.3233/JAD-201544. Full Text Open Access Copy
Miller-Rhodes, Patrick, et al. “This Is Your Brain on (Low) Glucose.” Trends Neurosci, vol. 43, no. 12, Dec. 2020, pp. 933–35. Pubmed, doi:10.1016/j.tins.2020.09.002. Full Text
Yang, Ting, et al. “Neuroinflammation after surgery: from mechanisms to therapeutic targets.” Nat Immunol, vol. 21, no. 11, Nov. 2020, pp. 1319–26. Pubmed, doi:10.1038/s41590-020-00812-1. Full Text
Wang, Dian-Shi, et al. “Targeting microglia to mitigate perioperative neurocognitive disorders.” Br J Anaesth, vol. 125, no. 3, Sept. 2020, pp. 229–32. Pubmed, doi:10.1016/j.bja.2020.06.027. Full Text
Wang, Ping, et al. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimers Dement, vol. 16, no. 5, May 2020, pp. 734–49. Pubmed, doi:10.1002/alz.12064. Full Text
Bassi, Gabriel S., et al. “Anatomical and clinical implications of vagal modulation of the spleen.” Neurosci Biobehav Rev, vol. 112, May 2020, pp. 363–73. Pubmed, doi:10.1016/j.neubiorev.2020.02.011. Full Text
Eckenhoff, Roderic G., et al. “Perioperative Neurocognitive Disorder: State of the Preclinical Science.” Anesthesiology, vol. 132, no. 1, Jan. 2020, pp. 55–68. Pubmed, doi:10.1097/ALN.0000000000002956. Full Text
VanDusen, Keith W., et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis, vol. 75, no. 4, 2020, pp. 1319–28. Pubmed, doi:10.3233/JAD-191185. Full Text Open Access Copy
Miller-Rhodes, Patrick, et al. “The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.” J Neuroinflammation, vol. 16, no. 1, Oct. 2019, p. 193. Pubmed, doi:10.1186/s12974-019-1582-5. Full Text
Pages
Devinney, Michael, et al. “METABOLIPIDOMIC ANALYSIS OF CEREBROSPINAL FLUID REVEALS INCREASED ARACHIDONIC ACID-DERIVED LIPIDS AND SPECIALIZED PRO-RESOLVING MEDIATORS 24 HRS AND 6-WEEKS FOLLOWING SURGERY AND ANESTHESIA.” Anesthesia and Analgesia, vol. 128, 2019, pp. 485–86.