Rachel Alison Adcock

Rachel Alison Adcock

Associate Professor of Psychiatry and Behavioral Sciences

External Address: 
Center for Cognitive Neuroscie, Durham, NC 27708
Internal Office Address: 
Box 90999, Durham, NC 27708-0999
Phone: 
919.681.7486

Overview

Dr. Adcock received her undergraduate degree in psychology from Emory University and her MD and PhD in Neurobiology from Yale University.  She completed her psychiatry residency training at Langley Porter Psychiatric Institute at UC-San Francisco and did neurosciences research as a postdoctoral fellow at UC-SF, the San Francisco VA Medical Center, and Stanford before joining the Duke faculty in 2007. Her work has been funded by NIDA, NIMH, NSF and Alfred P. Sloan and Klingenstein Fellowships in the Neurosciences, and the Brain & Behavior Research Foundation, and honored by NARSAD awards, the 2012 National Academy of Sciences Seymour Benzer Lectureship, and the 2015 ABAI BF Skinner Lectureship. The overall goals of her research program are to understand how brain systems for motivation support learning and to use mechanistic understanding of how behavior changes biology to meet the challenge of developing new therapies appropriate for early interventions for mental illness.

Education & Training

  • Ph.D., Yale University 1999

  • M.D., Yale University School of Medicine 1999

Selected Grants

Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Duke CTSA (TL1) awarded by National Institutes of Health (Mentor). 2018 to 2023

Medical Scientist Training Program awarded by National Institutes of Health (Steering Committee Member). 1997 to 2022

Increasing Motivation in ADHD Via Self-activation of VTA awarded by National Institutes of Health (Principal Investigator). 2016 to 2021

Targeting reward dysfunction as a mechanism to improve smoking cessation awarded by National Institutes of Health (Co-Mentor). 2016 to 2021

Instructed Activation of the Human Dopaminergic Midbrain Using Real-Time fMRI in Nicotine-Dependent Individuals awarded by Brain and Behavior Research Foundation (Principal Investigator). 2016 to 2020

Smoking/Nicotine Dependence in Attention Deficit Hyperactivity Disorder (ADHD) awarded by National Institutes of Health (Collaborator). 2017 to 2020

Modeling the Neurobehavioral Basis of Extrinsic and Volitional Motivation in ADHD awarded by National Institutes of Health (Principal Investigator). 2017 to 2020

Environment Cue-Reactivity: Brain, Behavior and Clinical Outcomes in Tobacco Use awarded by National Institutes of Health (Co Investigator). 2014 to 2020

Pages

Murty, V. P., and R. A. Adcock. “Distinct medial temporal lobe network states as neural contexts for motivated memory formation.” The Hippocampus from Cells to Systems: Structure, Connectivity, and Functional Contributions to Memory and Flexible Cognition, 2017, pp. 467–501. Scopus, doi:10.1007/978-3-319-50406-3_15. Full Text

Haugg, Amelie, et al. “Can we predict real-time fMRI neurofeedback learning success from pretraining brain activity?Hum Brain Mapp, July 2020. Pubmed, doi:10.1002/hbm.25089. Full Text

Botvinik-Nezer, Rotem, et al. “Variability in the analysis of a single neuroimaging dataset by many teams.Nature, vol. 582, no. 7810, June 2020, pp. 84–88. Pubmed, doi:10.1038/s41586-020-2314-9. Full Text

Stanek, Jessica K., et al. “Expected Reward Value and Reward Uncertainty Have Temporally Dissociable Effects on Memory Formation.J Cogn Neurosci, vol. 31, no. 10, Oct. 2019, pp. 1443–54. Pubmed, doi:10.1162/jocn_a_01411. Full Text

Wang, Chenhao, et al. “Large-Scale Network Topology Reveals Heterogeneity in Individuals With at Risk Mental State for Psychosis: Findings From the Longitudinal Youth-at-Risk Study.Cereb Cortex, vol. 28, no. 12, Dec. 2018, pp. 4234–43. Pubmed, doi:10.1093/cercor/bhx278. Full Text

MacDuffie, Katherine E., et al. “Single session real-time fMRI neurofeedback has a lasting impact on cognitive behavioral therapy strategies.Neuroimage Clin, vol. 19, 2018, pp. 868–75. Pubmed, doi:10.1016/j.nicl.2018.06.009. Full Text

Chiew, Kimberly S., et al. “Motivational valence alters memory formation without altering exploration of a real-life spatial environment.Plos One, vol. 13, no. 3, 2018, p. e0193506. Pubmed, doi:10.1371/journal.pone.0193506. Full Text

Dickerson, Kathryn, and R. Alison Adcock. “Motivation and Memory.” Stevens’ Handbook of Experimental Psychology and Cognitive Neuroscience, John Wiley & Sons, Inc., 2018. Manual, doi:10.1002/9781119170174.epcn107. Full Text

Horne, Alexandra J., et al. “Relating Sensory, Cognitive, and Neural Factors to Older Persons' Perceptions about Happiness: An Exploratory Study.J Aging Res, vol. 2018, 2018, p. 4930385. Pubmed, doi:10.1155/2018/4930385. Full Text Open Access Copy

Pages

Erwin, Savannah R., et al. “2.19 HARNESSING PERFECTIONISM: THE ROLE OF EMOTION REGULATION AND REWARD EXPERIENCE.” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 58, no. 10, Elsevier BV, 2019, pp. S177–S177. Crossref, doi:10.1016/j.jaac.2019.08.111. Full Text

Adcock, Rachel, et al. “144. Cognitive Neurostimulation: Volitional Regulation of Ventral Tegmental Area.” Biological Psychiatry, vol. 85, no. 10, Elsevier BV, 2019, pp. S60–S60. Crossref, doi:10.1016/j.biopsych.2019.03.158. Full Text

Dickerson, Kathryn, et al. “Real-Time fMRI as a CBT Adjunct: Predicting the Behavioral Impact of Neurofeedback.” Neuropsychopharmacology, vol. 43, NATURE PUBLISHING GROUP, 2018, pp. S125–26.

Dickerson, Kathryn, et al. “T157. Using Real-Time fMRI Neurofeedback as a Tool for Demonstrating Therapeutic Efficacy.” Biological Psychiatry, vol. 83, no. 9, Elsevier BV, 2018, pp. S189–S189. Crossref, doi:10.1016/j.biopsych.2018.02.494. Full Text

Liu, Siwei, et al. “LONGITUDINAL WORKING MEMORY FUNCTIONAL DYSCONNECTIVITY REFLECTS HETEROGENEITY IN INDIVIDUALS AT ULTRA HIGH RISK FOR PSYCHOSIS.” Schizophrenia Bulletin, vol. 44, OXFORD UNIV PRESS, 2018, pp. S281–S281.

Dickerson, Kathryn, et al. “Cognitive Neurostimulation of the Dopamine System.” Neuropsychopharmacology, vol. 41, NATURE PUBLISHING GROUP, 2016, pp. S500–01.

Adcock, R. Alison, et al. “DORSOLATERAL PREFRONTAL CORTEX DRIVES MESOLIMBIC DOPAMINERGIC REGIONS DURING MOTIVATED BEHAVIOR: INSIGHTS FROM DYNAMIC CAUSAL MODELING AND FMRI IN AT-RISK ADOLESCENTS.” Schizophrenia Research, vol. 153, ELSEVIER SCIENCE BV, 2014, pp. S38–S38.

Sumner, Elizabeth, et al. “DOPAMINERGIC MODULATION OF REWARD-MOTIVATED MEMORY.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 227–28.

Murty, Vishnu, et al. “THE ACTIVE AVOIDANCE OF THREAT ENHANCES NEURAL SENSITIVITY TO EXPECTANCY VIOLATION.Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 183–183.

Clement, Nathan, and R. Alison Adcock. “MOVE FASTER TO LEARN BETTER: EXPLORATION SPEED IMPACTS LEARNING ABOUT OBJECTS AND THEIR LOCATIONS.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 79–80.

Pages