Rachel Alison Adcock
Associate Professor of Psychiatry and Behavioral Sciences
Links
Overview
Dr. Adcock received her undergraduate degree in psychology from Emory University and her MD and PhD in Neurobiology from Yale University. She completed her psychiatry residency training at Langley Porter Psychiatric Institute at UC-San Francisco and did neurosciences research as a postdoctoral fellow at UC-SF, the San Francisco VA Medical Center, and Stanford before joining the Duke faculty in 2007. Her work has been funded by NIDA, NIMH, NSF and Alfred P. Sloan and Klingenstein Fellowships in the Neurosciences, and the Brain & Behavior Research Foundation, and honored by NARSAD awards, the 2012 National Academy of Sciences Seymour Benzer Lectureship, and the 2015 ABAI BF Skinner Lectureship. The overall goals of her research program are to understand how brain systems for motivation support learning and to use mechanistic understanding of how behavior changes biology to meet the challenge of developing new therapies appropriate for early interventions for mental illness.
Selected Grants
Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024
Duke CTSA (TL1) awarded by National Institutes of Health (Mentor). 2018 to 2023
Medical Scientist Training Program awarded by National Institutes of Health (Steering Committee Member). 1997 to 2022
A High-Performance 3T MRI for Brain Imaging awarded by National Institutes of Health (Minor User). 2021 to 2022
Targeting reward dysfunction as a mechanism to improve smoking cessation awarded by National Institutes of Health (Co-Mentor). 2016 to 2022
Instructed Activation of the Human Dopaminergic Midbrain Using Real-Time fMRI in Nicotine-Dependent Individuals awarded by Brain and Behavior Research Foundation (Principal Investigator). 2016 to 2021
Longitudinal Investigation of the Neurobiological Underpinnings of Risk Behavior in ADHD throughout the Adolescent Transition: The Key Role of Cognitive Control and Motivation Network Development awarded by University of North Carolina - Chapel Hill (Principal Investigator). 2019 to 2021
Increasing Motivation in ADHD Via Self-activation of VTA awarded by National Institutes of Health (Principal Investigator). 2016 to 2021
Smoking/Nicotine Dependence in Attention Deficit Hyperactivity Disorder (ADHD) awarded by National Institutes of Health (Collaborator). 2017 to 2020
Modeling the Neurobehavioral Basis of Extrinsic and Volitional Motivation in ADHD awarded by National Institutes of Health (Principal Investigator). 2017 to 2020
Pages
Murty, V. P., and R. A. Adcock. “Distinct medial temporal lobe network states as neural contexts for motivated memory formation.” The Hippocampus from Cells to Systems: Structure, Connectivity, and Functional Contributions to Memory and Flexible Cognition, 2017, pp. 467–501. Scopus, doi:10.1007/978-3-319-50406-3_15. Full Text
Haugg, Amelie, et al. “Can we predict real-time fMRI neurofeedback learning success from pretraining brain activity?” Hum Brain Mapp, vol. 41, no. 14, Oct. 2020, pp. 3839–54. Pubmed, doi:10.1002/hbm.25089. Full Text
Botvinik-Nezer, Rotem, et al. “Variability in the analysis of a single neuroimaging dataset by many teams.” Nature, vol. 582, no. 7810, June 2020, pp. 84–88. Pubmed, doi:10.1038/s41586-020-2314-9. Full Text
MacInnes, Jeff J., et al. “Pyneal: Open Source Real-Time fMRI Software.” Front Neurosci, vol. 14, 2020, p. 900. Pubmed, doi:10.3389/fnins.2020.00900. Full Text
Ho, New Fei, et al. “Correction: Progressive decline in hippocampal CA1 volume in individuals at ultra-high-risk for psychosis who do not remit: findings from the longitudinal youth at risk study.” Neuropsychopharmacology, vol. 44, no. 12, Nov. 2019, p. 2144. Pubmed, doi:10.1038/s41386-019-0477-6. Full Text Open Access Copy
Stanek, Jessica K., et al. “Expected Reward Value and Reward Uncertainty Have Temporally Dissociable Effects on Memory Formation.” J Cogn Neurosci, vol. 31, no. 10, Oct. 2019, pp. 1443–54. Pubmed, doi:10.1162/jocn_a_01411. Full Text
Duffy, Korrina A., et al. “Enhancing activation in the right temporoparietal junction using theta-burst stimulation: Disambiguating between two hypotheses of top-down control of behavioral mimicry.” Plos One, vol. 14, no. 1, 2019, p. e0211279. Pubmed, doi:10.1371/journal.pone.0211279. Full Text Open Access Copy
Wang, Chenhao, et al. “Large-Scale Network Topology Reveals Heterogeneity in Individuals With at Risk Mental State for Psychosis: Findings From the Longitudinal Youth-at-Risk Study.” Cereb Cortex, vol. 28, no. 12, Dec. 2018, pp. 4234–43. Pubmed, doi:10.1093/cercor/bhx278. Full Text
MacDuffie, Katherine E., et al. “Single session real-time fMRI neurofeedback has a lasting impact on cognitive behavioral therapy strategies.” Neuroimage Clin, vol. 19, 2018, pp. 868–75. Pubmed, doi:10.1016/j.nicl.2018.06.009. Full Text Open Access Copy
Chiew, Kimberly S., et al. “Motivational valence alters memory formation without altering exploration of a real-life spatial environment.” Plos One, vol. 13, no. 3, 2018, p. e0193506. Pubmed, doi:10.1371/journal.pone.0193506. Full Text
Dickerson, Kathryn, and R. Alison Adcock. “Motivation and Memory.” Stevens’ Handbook of Experimental Psychology and Cognitive Neuroscience, John Wiley & Sons, Inc., 2018. Manual, doi:10.1002/9781119170174.epcn107. Full Text
Pages
Erwin, Savannah R., et al. “2.19 HARNESSING PERFECTIONISM: THE ROLE OF EMOTION REGULATION AND REWARD EXPERIENCE.” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 58, no. 10, Elsevier BV, 2019, pp. S177–S177. Crossref, doi:10.1016/j.jaac.2019.08.111. Full Text
Adcock, Rachel, et al. “144. Cognitive Neurostimulation: Volitional Regulation of Ventral Tegmental Area.” Biological Psychiatry, vol. 85, no. 10, Elsevier BV, 2019, pp. S60–S60. Crossref, doi:10.1016/j.biopsych.2019.03.158. Full Text
Dickerson, Kathryn, et al. “Real-Time fMRI as a CBT Adjunct: Predicting the Behavioral Impact of Neurofeedback.” Neuropsychopharmacology, vol. 43, NATURE PUBLISHING GROUP, 2018, pp. S125–26.
Dickerson, Kathryn, et al. “T157. Using Real-Time fMRI Neurofeedback as a Tool for Demonstrating Therapeutic Efficacy.” Biological Psychiatry, vol. 83, no. 9, Elsevier BV, 2018, pp. S189–S189. Crossref, doi:10.1016/j.biopsych.2018.02.494. Full Text
Liu, Siwei, et al. “LONGITUDINAL WORKING MEMORY FUNCTIONAL DYSCONNECTIVITY REFLECTS HETEROGENEITY IN INDIVIDUALS AT ULTRA HIGH RISK FOR PSYCHOSIS.” Schizophrenia Bulletin, vol. 44, OXFORD UNIV PRESS, 2018, pp. S281–S281.
Dickerson, Kathryn, et al. “Cognitive Neurostimulation of the Dopamine System.” Neuropsychopharmacology, vol. 41, NATURE PUBLISHING GROUP, 2016, pp. S500–01.
Adcock, R. Alison, et al. “DORSOLATERAL PREFRONTAL CORTEX DRIVES MESOLIMBIC DOPAMINERGIC REGIONS DURING MOTIVATED BEHAVIOR: INSIGHTS FROM DYNAMIC CAUSAL MODELING AND FMRI IN AT-RISK ADOLESCENTS.” Schizophrenia Research, vol. 153, ELSEVIER SCIENCE BV, 2014, pp. S38–S38.
Sumner, Elizabeth, et al. “DOPAMINERGIC MODULATION OF REWARD-MOTIVATED MEMORY.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 227–28.
Murty, Vishnu, et al. “THE ACTIVE AVOIDANCE OF THREAT ENHANCES NEURAL SENSITIVITY TO EXPECTANCY VIOLATION.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 183–183.
Clement, Nathan, and R. Alison Adcock. “MOVE FASTER TO LEARN BETTER: EXPLORATION SPEED IMPACTS LEARNING ABOUT OBJECTS AND THEIR LOCATIONS.” Journal of Cognitive Neuroscience, MIT PRESS, 2013, pp. 79–80.