Rodger Alan Liddle

Rodger Alan Liddle

Professor of Medicine

External Address: 
1033A GSRB-1 Bldg, Durham, NC 27710
Internal Office Address: 
Duke Box 103859, 1033A GSRB-1, Durham, NC 27710
Phone: 
919.681.6380

Overview

Our laboratory has two major research interests:

Enteroendocrine Cell Biology

Enteroendocrine cells (EECs) are sensory cells of the gut that send signals throughout the body.  They have the ability to sense food and nutrients in the lumen of the intestine and secrete hormones into the blood.  Our laboratory has had a longstanding interest in two types of EECs that regulate satiety and signal the brain to stop eating.   Cholecystokinin (CCK) is secreted from EECs of the upper small intestine and regulates the ingestion and digestion of food through effects on the stomach, gallbladder, pancreas and brain.  Peptide YY (PYY) is secreted from EECs of the small intestine and colon and regulates satiety.  We recently demonstrated that CCK and PYY cells not only secrete hormones but are directly connected to nerves through unique cellular processes called ‘neuropods’.  Our laboratory is devoted to understanding EECs signaling and its role in disease.

Pancreatitis

Pancreatitis is an inflammatory disease of the pancreas compounded by intrapancreaatic activation of digestive enzymes.  Our laboratory is studying the influence of nerves on the development of pancreatitis. Neurogenic inflammation results from the release of bioactive substances from sensory neurons in the pancreas causing vasodilatation, edema, and inflammatory cell infiltration producing tissue necrosis. Our goal is to identify the agents that activate sensory neurons, characterize the receptors on sensory nerves that mediate these actions, and determine the effects of neural stimulation on pancreatic injury with the long-term objective of developing strategies to reduce neurogenic inflammation to treat pancreatitis. 

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Education & Training

  • Gastroenterology Fellowship, Gastroenterology, University of California - San Francisco 1981 - 1984

  • Residency, Generalinternal Medicine, University of California - San Francisco 1979 - 1981

  • Internship, General Internal Medicine, University of California - San Francisco 1978 - 1979

  • M.D., Vanderbilt University 1978

  • B.S., University of Utah 1972

Selected Grants

Neural sensing of gut bacteria awarded by National Institutes of Health (Principal Investigator). 2020 to 2025

Endocrinology and Metabolism Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Metabolic regulation of pancreatitis awarded by National Institutes of Health (Principal Investigator). 2020 to 2024

Mechanisms of mechanically-induced acute pancreatitis awarded by National Institutes of Health (Principal Investigator). 2019 to 2023

A Novel Integrative Pathway Regulating Intestinal Glucose Sensing awarded by Pew Scholars Program (Co Investigator). 2018 to 2021

The role of gut endocrine cells in Parkinson's Disease awarded by National Institutes of Health (Principal Investigator). 2016 to 2021

Medical Student Research Training Supplement awarded by National Institutes of Health (Co-Director). 2020 to 2021

T32-Diversity: NRSA Diversity Supplement Award awarded by National Institutes of Health (Co-Director). 1988 to 2021

Transmission electron microscope (TEM) awarded by National Institutes of Health (Major User). 2019 to 2020

Identifying genes required for digestive physiology and lipid metabolism awarded by Carnegie Institution of Washington (Co Investigator). 2013 to 2020

Pages

Liddle, R. A. “Regulation of Pancreatic Secretion.” Physiology of the Gastrointestinal Tract: Sixth Edition, vol. 2–2, 2018, pp. 895–929. Scopus, doi:10.1016/B978-0-12-809954-4.00040-2. Full Text

Diamond, P., and R. Liddle. “Aftershock: The post-crisis social investment welfare state in Europe.” Towards a Social Investment Welfare State?: Ideas, Policies and Challenges, 2011, pp. 285–308.

Swain, Sandip M., et al. “TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.J Clin Invest, vol. 130, no. 5, May 2020, pp. 2527–41. Pubmed, doi:10.1172/JCI134111. Full Text

Ye, Lihua, et al. “High fat diet induces microbiota-dependent silencing of enteroendocrine cells.Elife, vol. 8, Dec. 2019. Pubmed, doi:10.7554/eLife.48479. Full Text

Liddle, Rodger A. “Neuropods.Cell Mol Gastroenterol Hepatol, vol. 7, no. 4, 2019, pp. 739–47. Pubmed, doi:10.1016/j.jcmgh.2019.01.006. Full Text

Liddle, Rodger A. “Parkinson's disease from the gut.Brain Res, vol. 1693, no. Pt B, Aug. 2018, pp. 201–06. Pubmed, doi:10.1016/j.brainres.2018.01.010. Full Text

Liddle, Rodger A. “Interactions of Gut Endocrine Cells with Epithelium and Neurons.Compr Physiol, vol. 8, no. 3, June 2018, pp. 1019–30. Pubmed, doi:10.1002/cphy.c170044. Full Text

Romac, Joelle M. J., et al. “Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.Nat Commun, vol. 9, no. 1, Apr. 2018, p. 1715. Pubmed, doi:10.1038/s41467-018-04194-9. Full Text

Kalloo, A., and R. Liddle. “Editorial introductions.” Current Opinion in Gastroenterology, vol. 33, no. 5, Sept. 2017, p. v. Scopus, doi:10.1097/MOG.0000000000000391. Full Text

Chandra, Rashmi, et al. “α-Synuclein in gut endocrine cells and its implications for Parkinson's disease.Jci Insight, vol. 2, no. 12, June 2017. Pubmed, doi:10.1172/jci.insight.92295. Full Text

Ye, Lihua, and Rodger A. Liddle. “Gastrointestinal hormones and the gut connectome.Curr Opin Endocrinol Diabetes Obes, vol. 24, no. 1, Feb. 2017, pp. 9–14. Pubmed, doi:10.1097/MED.0000000000000299. Full Text

Liddle, Rodger A. “Location, Location, Location . . . It Is Important in Pancreatitis, Too.Cell Mol Gastroenterol Hepatol, vol. 3, no. 1, Jan. 2017, pp. 6–7. Pubmed, doi:10.1016/j.jcmgh.2016.10.005. Full Text

Pages

Chiang, Ryan S., et al. “1089 Hypophosphatemia in Patients With Alcoholic Hepatitis.” American Journal of Gastroenterology, vol. 114, no. 1, Ovid Technologies (Wolters Kluwer Health), 2019, pp. S615–16. Crossref, doi:10.14309/01.ajg.0000593888.05451.17. Full Text

Himmerkus, N., et al. “Water impermeability of the thick ascending limb of Henle's loop and the collecting duct depends on ILDR1 expression.” Acta Physiologica, vol. 219, WILEY, 2017, pp. 26–28.

Kaelberer, Melanie M., et al. “128 A Gut-Brain Sensory Neuroepithelial Circuit.” Gastroenterology, vol. 150, no. 4, Elsevier BV, 2016, pp. S30–31. Crossref, doi:10.1016/s0016-5085(16)30229-3. Full Text

Shahid, Rafiq A., et al. “Bile Acid-Induced Acute Pancreatitis in Mice Is Caused by Acinar Cell Leukotriene B-4 Secretion Through a Calcium-Independent Pathway.” Gastroenterology, vol. 146, no. 5, W B SAUNDERS CO-ELSEVIER INC, 2014, pp. S297–S297.

Shahid, Rafiq A., et al. “Bile Acid-Induced Acute Pancreatitis Is Mediated by Acinar Cell Leukotriene B-4 Secretion.” Gastroenterology, vol. 144, no. 5, W B SAUNDERS CO-ELSEVIER INC, 2013, pp. S320–S320.

Chandra, Rashmi, et al. “Immunoglobulin-Like Domain Containing Receptor Mediates Fat-Stimulated Cholecystokinin Secretion.” Gastroenterology, vol. 144, no. 5, W B SAUNDERS CO-ELSEVIER INC, 2013, pp. S8–S8.

Shahid, Rafiq A., et al. “Leukotriene B-4 Activation of TRPV1 Mediates Acute Pancreatitis Induced by Pancreatic Duct Infusion of Sodium Taurocholate in Mice.” Gastroenterology, vol. 142, no. 5, W B SAUNDERS CO-ELSEVIER INC, 2012, pp. S316–S316.

Vigna, Steven R., et al. “The Role of TRPV1 in Ethanol Plus Fatty Acid-Induced Acute Pancreatitis in Mice.” Gastroenterology, vol. 142, no. 5, W B SAUNDERS CO-ELSEVIER INC, 2012, pp. S459–60.

Bohorquez, Diego V., et al. “PYY-Secreting L Cells Connect to Enteric Myofibroblasts and Neurites Through Axon-Like Basal Processes.” Gastroenterology, vol. 140, no. 5, W B SAUNDERS CO-ELSEVIER INC, 2011, pp. S148–S148.

Bohorquez, Diego V., et al. “The enteroendocrine PYY cell interacts with neurites of the enteric nervous system through axon-like basal process.” Faseb Journal, vol. 25, FEDERATION AMER SOC EXP BIOL, 2011.

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