Professor of Neurosurgery
Dr. Nandan Lad is a neurosurgeon, scientist, and entrepreneur and an Associate Professor at Duke University Medical Center with a focus in Neuromodulation and Neurorestoration. He is Director of the Duke NeuroInnovations Program, a systematic approach to medical device innovation to large unmet clinical needs.
He completed his MD and PhD in Biochemistry at Chicago Medical School and his neurosurgical residency training at Stanford with fellowships in Surgical Innovation and Functional Neurosurgery.
Neuromodulation; Neurorestoration; Bioengineering; Medical Device Design; Clinical Trials; Data Science; Health Outcomes.
ECAP Study: A prospective, multicenter, single-arm study examining ECAP-controlled, closed-loop stimulation with the Evoke Spinal Cord Stimulator (SCS) System to treat patients with chronic pain of the trunk and/or limbs. awarded by Saluda Medical Americas (Principal Investigator). 2021 to 2026
A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation in patients with Subacute Thoracic Spinal Cord Injury to improve Pain and augment Rehabilitation awarded by National Institutes of Health (Principal Investigator). 2020 to 2025
NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health (Mentor). 2009 to 2025
A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Intracerebral Stem Cells (CTX0E03) in Subjects with Disability Following an Ischemic Stroke (PISCES III) awarded by ReNeuron Group plc (Principal Investigator). 2019 to 2024
NEVRO NSRBP awarded by Nevro Corp (Principal Investigator). 2018 to 2023
A Post-Market, Multicenter, Prospective, Randomized Clinical Trial Comparing 10 kHz Spinal Cord Stimulation (HF10¿ Therapy) Combined with Conventional Medical Management to Conventional Medical Management Alone in the Treatment of Chronic, Intractabl awarded by Nevro Corp (Principal Investigator). 2018 to 2023
A Randomized, Controlled, Multicenter Trial of Percutaneous Peripheral Nerve Stimulation (PNS) for the Treatment of Back Pain awarded by SPR Therapeutics, LLC (Investigator). 2020 to 2022
ReActiv8 Implantable Neuro-stimulation system for Chronic Low Back Pain awarded by Mainstay Medical Ltd. (Principal Investigator). 2017 to 2021
Nevro HF10 Outcomes Analysis awarded by Nevro Corp (Principal Investigator). 2020 to 2021
Validation of Novel Therapeutic Approach for Leptomeningeal Metastases awarded by Minnetronix, Inc (Principal Investigator). 2016 to 2021
Adil, Syed M., et al. “Impact of Spinal Cord Stimulation on Opioid Dose Reduction: A Nationwide Analysis.” Neurosurgery, vol. 88, no. 1, Dec. 2020, pp. 193–201. Pubmed, doi:10.1093/neuros/nyaa353. Full Text
Krucoff, Max O., et al. “Spinal cord stimulation and rehabilitation in an individual with chronic complete L1 paraplegia due to a conus medullaris injury: motor and functional outcomes at 18 months.” Spinal Cord Ser Cases, vol. 6, no. 1, Oct. 2020, p. 96. Pubmed, doi:10.1038/s41394-020-00345-7. Full Text
Spears, Charis A., et al. “Health Care Resource Utilization and Management of Chronic, Refractory Low Back Pain in the United States.” Spine (Phila Pa 1976), vol. 45, no. 20, Oct. 2020, pp. E1333–41. Pubmed, doi:10.1097/BRS.0000000000003572. Full Text
Patel, Naresh, et al. “High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Nonsurgical Refractory Back Pain: Design of a Pragmatic, Multicenter, Randomized Controlled Trial.” Pain Practice : The Official Journal of World Institute of Pain, Aug. 2020. Epmc, doi:10.1111/papr.12945. Full Text
Cho, James, et al. “Enhancing Reality: A Systematic Review of Augmented Reality in Neuronavigation and Education.” World Neurosurg, vol. 139, July 2020, pp. 186–95. Pubmed, doi:10.1016/j.wneu.2020.04.043. Full Text
Williamson, Theresa, et al. “Withdrawal of Life-Supporting Treatment in Severe Traumatic Brain Injury.” Jama Surg, June 2020. Pubmed, doi:10.1001/jamasurg.2020.1790. Full Text
Khani, Mohammadreza, et al. “In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy.” Fluids Barriers Cns, vol. 17, no. 1, Mar. 2020, p. 23. Pubmed, doi:10.1186/s12987-020-00185-5. Full Text
Kiyani, Musa, et al. “The longitudinal health economic impact of viral encephalitis in the United States.” J Med Microbiol, vol. 69, no. 2, Feb. 2020, pp. 270–79. Pubmed, doi:10.1099/jmm.0.001153. Full Text
Elsamadicy, Aladine A., et al. “Prevalence and Cost Analysis of Chronic Pain After Hernia Repair: A Potential Alternative Approach With Neurostimulation.” Neuromodulation : Journal of the International Neuromodulation Society, vol. 22, no. 8, Dec. 2019, pp. 960–69. Epmc, doi:10.1111/ner.12871. Full Text
Adil, Syed M., et al. “Healthcare Economics of Hydrocephalus After Aneurysmal Subarachnoid Hemorrhage in the United States.” Transl Stroke Res, vol. 10, no. 6, Dec. 2019, pp. 650–63. Pubmed, doi:10.1007/s12975-019-00697-9. Full Text
Williamson, Theresa, et al. “UNDERSTANDING DECISIONS TO UNDERSTAND OUTCOMES: FACTORS PREDICTING SURGERY FOLLOWING SEVERE TRAUMATIC BRAIN INJURY.” Journal of Neurotrauma, vol. 35, no. 16, MARY ANN LIEBERT, INC, 2018, pp. A279–80.
Elsamadicy, Aladine Abdalla, et al. “Neurosurgery medical profession liability claims in the United States.” Journal of Neurosurgery, vol. 128, no. 4, AMER ASSOC NEUROLOGICAL SURGEONS, 2018, pp. 43–43.
Farber, Samuel Harrison, et al. “Modeling Healthcare Expenditures associated with Implantable Neurostimulation for Headache Disorders.” Journal of Neurosurgery, vol. 124, no. 4, AMER ASSOC NEUROLOGICAL SURGEONS, 2016, pp. A1165–A1165.
Petraglia, Frank William, et al. “Longer Delays from Pain Diagnosis to Spinal Cord Stimulation Result in Higher Post-Implant Healthcare Utilization.” Journal of Neurosurgery, vol. 123, no. 2, AMER ASSOC NEUROLOGICAL SURGEONS, 2015, pp. A511–A511.
Patel, Vipul Vikrambhai, et al. “Impact of Tailoring Spinal Cord Stimulation Therapy on Clinical Outcomes.” Journal of Neurosurgery, vol. 123, no. 2, AMER ASSOC NEUROLOGICAL SURGEONS, 2015, pp. A516–A516.
Lad, Shivanand P., et al. “Neurostimulation for the Treatment of Headache Disorders: A Large, Retrospective Cohort Analysis.” Journal of Neurosurgery, vol. 122, no. 6, AMER ASSOC NEUROLOGICAL SURGEONS, 2015, pp. A1572–A1572.
Bagley, Jacob, et al. “Predictors And Implications Of Facial Nerve Dysfunction After Acoustic Neuroma Resection: A National Study.” Journal of Neurosurgery, vol. 119, no. 2, AMER ASSOC NEUROLOGICAL SURGEONS, 2013, pp. A563–64.
Babu, Ranjith, et al. “Treatment Of Intraspinal Abscess: Comparison Of Outcomes Following Surgical And Conservative Management.” Journal of Neurosurgery, vol. 119, no. 2, AMER ASSOC NEUROLOGICAL SURGEONS, 2013, pp. A575–A575.
Hazzard, Matthew Aaron, et al. “Comparison Of Management Options For Vertebral Compression Fractures And Impact On US Healthcare Resource Utilization.” Journal of Neurosurgery, vol. 119, no. 2, AMER ASSOC NEUROLOGICAL SURGEONS, 2013, pp. A585–86.
Choi, Jonathan, et al. “157 Utilization of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome.” Neurosurgery, vol. 71, no. 2, Oxford University Press (OUP), 2012, pp. E562–63. Crossref, doi:10.1227/01.neu.0000417747.62665.b7. Full Text