Sidney Arthur Simon

Sidney Arthur Simon

Professor Emeritus of Neurobiology

External Address: 
Bryan Research Building, 311 Research Drive Room 327C, Durham, NC 27710
Internal Office Address: 
Box 3209, Durham, NC 27710


Dr. Simon's laboratory studies the interaction of chemical stimuli with cultured and intact trigeminal ganglion neurons and taste receptor cells both in culture, in anesthetized and in awake behaving animals. We investigate how chemicals that are either bitter and/or irritating ( e.g., nicotine, capsaicin, colloidal particles) interact with particular types of receptors (e.g. nicotinic acetylcholine receptors or vanilloid receptors) to produce a bitter, irritating or painful sensation. We also investigate how these compounds evoke responses in various cortical regions such as the ventral tegmental area, orbitofrontal cortex and gustatory cortex. Our overall goal is to obtain a understanding of the events from the molecular to the behavioral levels that underlie gustatory and irritating sensations produced by chemical stimuli. We collaborate with the Nicolelis and Reinhart laboratories.

Another focus of Dr. Simon's laboratory is to investigate the physical chemical interactions that occur when peptides interact with membranes. To date we have focused on leader sequences. This work is in collaboration with the laboratory of Dr. Tom Mcintosh in the Cell Biology Department.

Education & Training

  • Ph.D., Northwestern University 1973

Selected Grants

Gustatory Processing and Satiety awarded by National Institutes of Health (Principal Investigator). 2000 to 2012

Training in Biomolecular and Tissue Engineering awarded by National Institutes of Health (Mentor). 2003 to 2009

Novel Anesthetic Mechanisms That Desensitize Nociceptors awarded by National Institutes of Health (Consultant). 2002 to 2008

Sensory Irritant Receptors and Particulate Inflammation awarded by National Institutes of Health (Principal Investigator). 2000 to 2006

Multimodal influences on cortical taste procesing awarded by National Institutes of Health (Administrative Assistant). 2002

Single Cell Calcium Recordings Of Mouse Dorsal Root Gan... awarded by Environmental Protection Agency (Principal Investigator). 1997 to 2000

Chemical Responses fo Oral Trigeminal Nerves awarded by National Institutes of Health (Principal Investigator). 1991 to 2000

Chemical Responses Of Oral Trigeminal Nerves awarded by National Institutes of Health (Principal Investigator). 1996 to 1999

(98-0050) Isothermal Titration Calorimetry for Biological Research awarded by (Co-Principal Investigator). 1998 to 1999

Short And Long-Range Forces Between Membrane Surfaces awarded by National Institutes of Health (Co-Principal Investigator). 1980 to 1999


Simon, S. A. Series preface. 2016.

Simon, S. A. Series preface. 2016.

Simon, S. A. Series preface. 2016.

Simon, S. A. Series preface. 2015. Scopus, doi:10.1201/b18126. Full Text

Simon, S. A. Series preface. 2014. Scopus, doi:10.1201/b16511. Full Text

Simon, S. A. Series preface. 2012. Scopus, doi:10.1201/b12215. Full Text

Simon, S. A., and M. A. L. Nicolelis. Series Preface. 2011, pp. xii–xiii.

Simon, S. A., and M. A. L. Nicolelis. Neurobiology of Depression. 2011, pp. 1–481.

Simon, S. A., and M. A. L. Nicolelis. Series preface. 2011.

Simon, S. A., and A. L. N. Miguel. Series Preface. 2010. Scopus, doi:10.1201/9781420007350. Full Text


Simon, S. A., and R. Gutierrez. “TRP channels at the periphery of the taste and trigeminal systems.” Neurobiology of TRP Channels, 2017, pp. 113–24. Scopus, doi:10.4324/9781315152837. Full Text

Anibal Disalvo, E., and S. Simon. “Preface.” Permeability and Stability of Lipid Bilayers, 2017. Scopus, doi:10.1201/9780203743805. Full Text

Kramer, Randall, et al. Preface. Malaria control and elimination programme in the People’s Republic of China.. Vol. 86, 2014, pp. xvii–xxi. Pubmed, doi:10.1016/B978-0-12-800869-0.22001-5. Full Text

Simon, S. A. “Series preface.” Humanoid Robotics and Neuroscience: Science, Engineering and Society, 2014. Scopus, doi:10.1201/b17949. Full Text

Simon, S. A. Series preface. 2013. Scopus, doi:10.1201/b14859. Full Text

Oliveira-Maia, A. J., et al. “Neural ensemble recordings from central gustatory-reward pathways in awake and behaving animals.” Methods for Neural Ensemble Recordings, Second Edition, 2007, pp. 189–218.

Jones, S., et al. “Nicotinic receptors in the periphery.” Nicotinic Receptors in the Nervous System, 2001, pp. 81–112.

Leijon, Sara C. M., et al. “Oral thermosensing by murine trigeminal neurons: modulation by capsaicin, menthol and mustard oil..” J Physiol, vol. 597, no. 7, Apr. 2019, pp. 2045–61. Pubmed, doi:10.1113/JP277385. Full Text

Fonseca, Esmeralda, et al. “Sucrose intensity coding and decision-making in rat gustatory cortices..” Elife, vol. 7, Nov. 2018. Pubmed, doi:10.7554/eLife.41152. Full Text

Ortíz-Rentería, Miguel, et al. “TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain..” Proc Natl Acad Sci U S A, vol. 115, no. 7, Feb. 2018, pp. E1657–66. Pubmed, doi:10.1073/pnas.1715972115. Full Text

Villavicencio, Miguel, et al. “Encoding of Sucrose's Palatability in the Nucleus Accumbens Shell and Its Modulation by Exteroceptive Auditory Cues..” Front Neurosci, vol. 12, 2018. Pubmed, doi:10.3389/fnins.2018.00265. Full Text

Morales-Lázaro, Sara L., et al. “Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch..” Nat Commun, vol. 7, Oct. 2016. Pubmed, doi:10.1038/ncomms13092. Full Text

Hertz, L., et al. “Editorial: All 3 types of glial cells are important for memory formation.” Frontiers in Integrative Neuroscience, vol. 10, no. SEP2016, Sept. 2016. Scopus, doi:10.3389/fnint.2016.00031. Full Text

Kanju, Patrick, et al. “Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain..” Sci Rep, vol. 6, June 2016. Pubmed, doi:10.1038/srep26894. Full Text Open Access Copy

Kalyanasundar, B., et al. “The efficacy of the appetite suppressant, diethylpropion, is dependent on both when it is given (day vs. night) and under conditions of high fat dietary restriction..” Appetite, vol. 100, May 2016, pp. 152–61. Pubmed, doi:10.1016/j.appet.2016.01.036. Full Text

Gutierrez, Ranier, and Sidney A. Simon. “Why do people living in hot climates like their food spicy?.” Temperature (Austin), vol. 3, no. 1, Jan. 2016, pp. 48–49. Pubmed, doi:10.1080/23328940.2015.1119616. Full Text


Morales-Lázaro, Sara L., et al. “Inhibition of TRPV1 by an Unsaturated Fatty Acid.” Biophysical Journal, vol. 110, no. 3, Elsevier BV, 2016, pp. 284a-285a. Crossref, doi:10.1016/j.bpj.2015.11.1541. Full Text

Morales-Lázaro, Sara L., et al. “Steroidal Molecules as Possible Regulators of TRPV1 Channels.” Biophysical Journal, vol. 106, no. 2, Elsevier BV, 2014, pp. 333a-333a. Crossref, doi:10.1016/j.bpj.2013.11.1911. Full Text

Simon, S. A., et al. “Multisensory Processing of Gustatory Stimuli..” Chemosens Percept, vol. 1, no. 2, 2008, pp. 95–102. Pubmed, doi:10.1007/s12078-008-9014-4. Full Text

Simon, Sidney A. “AGFD 61-Multisensory processing in the gustatory system.” Abstracts of Papers of the American Chemical Society, vol. 234, AMER CHEMICAL SOC, 2007.

Oliveira-Maia, Albino Jorge, et al. “Cortical responses to the post-ingestive effects of sucrose in TRPM5-/- mice.” International Journal of Obesity, vol. 31, NATURE PUBLISHING GROUP, 2007, pp. S102–S102.