Stephen Lisberger

Stephen Lisberger

George Barth Geller Distinguished Professor for Research in Neurobiology

External Address: 
Bryan Research Building, 311 Research Drive Room 327D, Durham, NC 27710
Internal Office Address: 
Box 3209, Durham, NC 27710
Phone: 
919.681.7088

Overview

We investigate how the brain learns motor skills, and how we use what we see to guide how we move. Our approaches involve studies of eye movements using behavior, neural recordings, and computational analysis. Our work is done on behaving non-human primates. 

Education & Training

  • Ph.D., University of Washington 1976

Selected Grants

NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health (Mentor). 2009 to 2025

Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Canonical computations for motor learning by the cerebellar cortex micro-circuit awarded by National Institutes of Health (Principal Investigator). 2019 to 2024

Mechanisms underlying rapid adaptation in mouse visual cortex awarded by National Institutes of Health (Co-Sponsor). 2020 to 2023

Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022

Neural Control of Eye Movement awarded by National Institutes of Health (Principal Investigator). 2017 to 2022

Properties of the signals that drive cerebellar motor learning awarded by National Institutes of Health (Mentor). 2020 to 2022

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

Evaluating how inhibition shapes granule cell population codes awarded by National Institutes of Health (Co-Sponsor). 2021

Visual-motor integration in smooth pursuit eye movements awarded by National Institutes of Health (Principal Investigator). 2017 to 2021

Pages

Lee, Joonyeol, et al. “The Neural Basis for Response Latency in a Sensory-Motor Behavior.Cereb Cortex, vol. 30, no. 5, May 2020, pp. 3055–73. Pubmed, doi:10.1093/cercor/bhz294. Full Text

Herzfeld, David J., et al. “Principles of operation of a cerebellar learning circuit.Elife, vol. 9, Apr. 2020. Epmc, doi:10.7554/elife.55217. Full Text

Behling, Stuart, and Stephen G. Lisberger. “Different mechanisms for modulation of the initiation and steady-state of smooth pursuit eye movements.J Neurophysiol, vol. 123, no. 3, Mar. 2020, pp. 1265–76. Pubmed, doi:10.1152/jn.00710.2019. Full Text

Darlington, Timothy R., and Stephen G. Lisberger. “Mechanisms that allow cortical preparatory activity without inappropriate movement.Elife, vol. 9, Feb. 2020. Pubmed, doi:10.7554/eLife.50962. Full Text

Hall, Nathan J., et al. “Multiple components in direction learning in smooth pursuit eye movements of monkeys.J Neurophysiol, vol. 120, no. 4, Oct. 2018, pp. 2020–35. Pubmed, doi:10.1152/jn.00261.2018. Full Text

Darlington, Timothy R., et al. “Neural implementation of Bayesian inference in a sensorimotor behavior.Nat Neurosci, vol. 21, no. 10, Oct. 2018, pp. 1442–51. Pubmed, doi:10.1038/s41593-018-0233-y. Full Text

Raghavan, Ramanujan T., and Stephen G. Lisberger. “Responses of Purkinje cells in the oculomotor vermis of monkeys during smooth pursuit eye movements and saccades: comparison with floccular complex.J Neurophysiol, vol. 118, no. 2, Aug. 2017, pp. 986–1001. Pubmed, doi:10.1152/jn.00209.2017. Full Text

Darlington, Timothy R., et al. “Control of the strength of visual-motor transmission as the mechanism of rapid adaptation of priors for Bayesian inference in smooth pursuit eye movements.J Neurophysiol, vol. 118, no. 2, Aug. 2017, pp. 1173–89. Pubmed, doi:10.1152/jn.00282.2017. Full Text

Yang, Yan, and Stephen G. Lisberger. “Modulation of Complex-Spike Duration and Probability during Cerebellar Motor Learning in Visually Guided Smooth-Pursuit Eye Movements of Monkeys.Eneuro, vol. 4, no. 3, May 2017. Pubmed, doi:10.1523/ENEURO.0115-17.2017. Full Text

Lee, Joonyeol, et al. “Signal, Noise, and Variation in Neural and Sensory-Motor Latency.Neuron, vol. 90, no. 1, Apr. 2016, pp. 165–76. Pubmed, doi:10.1016/j.neuron.2016.02.012. Full Text

Pages

Boxer, A. L., et al. “The eyes have it: Distinct patterns of eye movement abnormalities in FTD relative to AD.” Neurology, vol. 64, no. 6, LIPPINCOTT WILLIAMS & WILKINS, 2005, pp. A100–A100.