Stephen Lisberger
George Barth Geller Distinguished Professor for Research in Neurobiology
Overview
We investigate how the brain learns motor skills, and how we use what we see to guide how we move. Our approaches involve studies of eye movements using behavior, neural recordings, and computational analysis. Our work is done on behaving non-human primates.
Selected Grants
NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health (Mentor). 2009 to 2025
Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024
Canonical computations for motor learning by the cerebellar cortex micro-circuit awarded by National Institutes of Health (Principal Investigator). 2019 to 2024
Mechanisms underlying rapid adaptation in mouse visual cortex awarded by National Institutes of Health (Co-Sponsor). 2020 to 2023
Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022
Neural Control of Eye Movement awarded by National Institutes of Health (Principal Investigator). 2017 to 2022
Properties of the signals that drive cerebellar motor learning awarded by National Institutes of Health (Mentor). 2020 to 2022
Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021
Evaluating how inhibition shapes granule cell population codes awarded by National Institutes of Health (Co-Sponsor). 2021
Visual-motor integration in smooth pursuit eye movements awarded by National Institutes of Health (Principal Investigator). 2017 to 2021
Pages
Lee, Joonyeol, et al. “The Neural Basis for Response Latency in a Sensory-Motor Behavior.” Cereb Cortex, vol. 30, no. 5, May 2020, pp. 3055–73. Pubmed, doi:10.1093/cercor/bhz294. Full Text
Herzfeld, David J., et al. “Principles of operation of a cerebellar learning circuit.” Elife, vol. 9, Apr. 2020. Epmc, doi:10.7554/elife.55217. Full Text
Behling, Stuart, and Stephen G. Lisberger. “Different mechanisms for modulation of the initiation and steady-state of smooth pursuit eye movements.” J Neurophysiol, vol. 123, no. 3, Mar. 2020, pp. 1265–76. Pubmed, doi:10.1152/jn.00710.2019. Full Text
Darlington, Timothy R., and Stephen G. Lisberger. “Mechanisms that allow cortical preparatory activity without inappropriate movement.” Elife, vol. 9, Feb. 2020. Pubmed, doi:10.7554/eLife.50962. Full Text
Hall, Nathan J., et al. “Multiple components in direction learning in smooth pursuit eye movements of monkeys.” J Neurophysiol, vol. 120, no. 4, Oct. 2018, pp. 2020–35. Pubmed, doi:10.1152/jn.00261.2018. Full Text
Darlington, Timothy R., et al. “Neural implementation of Bayesian inference in a sensorimotor behavior.” Nat Neurosci, vol. 21, no. 10, Oct. 2018, pp. 1442–51. Pubmed, doi:10.1038/s41593-018-0233-y. Full Text
Raghavan, Ramanujan T., and Stephen G. Lisberger. “Responses of Purkinje cells in the oculomotor vermis of monkeys during smooth pursuit eye movements and saccades: comparison with floccular complex.” J Neurophysiol, vol. 118, no. 2, Aug. 2017, pp. 986–1001. Pubmed, doi:10.1152/jn.00209.2017. Full Text
Darlington, Timothy R., et al. “Control of the strength of visual-motor transmission as the mechanism of rapid adaptation of priors for Bayesian inference in smooth pursuit eye movements.” J Neurophysiol, vol. 118, no. 2, Aug. 2017, pp. 1173–89. Pubmed, doi:10.1152/jn.00282.2017. Full Text
Yang, Yan, and Stephen G. Lisberger. “Modulation of Complex-Spike Duration and Probability during Cerebellar Motor Learning in Visually Guided Smooth-Pursuit Eye Movements of Monkeys.” Eneuro, vol. 4, no. 3, May 2017. Pubmed, doi:10.1523/ENEURO.0115-17.2017. Full Text
Lee, Joonyeol, et al. “Signal, Noise, and Variation in Neural and Sensory-Motor Latency.” Neuron, vol. 90, no. 1, Apr. 2016, pp. 165–76. Pubmed, doi:10.1016/j.neuron.2016.02.012. Full Text
Pages
Boxer, Adam L., et al. “"Slow down, don't look at that, look at me"! Mechanisms of cognitive and social impairment in neurodegenerative disease as revealed by the study of eye movements.” Annals of Neurology, vol. 60, no. 5, WILEY-LISS, 2006, pp. 626–626.
Boxer, A. L., et al. “The eyes have it: Distinct patterns of eye movement abnormalities in FTD relative to AD.” Neurology, vol. 64, no. 6, LIPPINCOTT WILLIAMS & WILKINS, 2005, pp. A100–A100.