Warren H. Meck

Warren H. Meck

Professor of Psychology and Neuroscience

External Address: 
572 Research Drive - PO 91050, Rm 3010 - GSRB2, Durham, NC 27708
Internal Office Address: 
Duke Box 91050, Durham, NC 27708-1050
Phone: 
919.660.5765

Overview

Research interests include the neuroanatomical and neuropharmacological basis of timing and time perception in the seconds-to-minutes range. This work relates to the striatal beat-frequency theory of interval timing as well as mode-control models of temporal integration and attentional time-sharing in humans and other animals. Current work focuses on the use of genomic and ensemble-recording techniques designed to identify the basic properties of interval timing and decision making in cortical-striatal circuits. Additional work utilizes neuroimaging techniques (e.g., EEG & fMRI) to examine temporal processing deficits in selected clinical populations. Another major focus for our research uses animal models to study developmental periods of dietary choline sensitivity that provide an ontogenetic mechanism for regulating memory capacity and precision in adulthood. This work includes the study of prenatal choline effects on sleep-dependent memory consolidation processes in adult rats and mice as well as inoculation against age-related impairments in spatial and temporal cognition.

Education & Training

  • Ph.D., Brown University 1982

Selected Grants

REU Site: Research Program in Mechanisms of Behavior awarded by National Science Foundation (Principal Investigator). 2004 to 2014

Representation of Temporal Information awarded by National Institutes of Health (Co-Principal Investigator). 2006 to 2010

Attentional Processing of Temporal Information awarded by National Institutes of Health (Co-Principal Investigator). 2002 to 2008

Center for Behavioral Neuroscience and Genomics awarded by National Institutes of Health (Co Investigator). 2002 to 2004

Undergraduate Neurosciences Summer Research Program in Mechanisms of Behavior awarded by National Science Foundation (Principal Investigator). 1999 to 2002

Functional and Neural Mechanisms of Interval Timing awarded by (Principal Investigator). 1997 to 2002

(97-0016) Functional and Neural Mechanisms of Interval Timing in Rats awarded by (Principal Investigator). 1997 to 2001

Nicotines Effect on Interval Timing -- FMRI Assessment awarded by National Institutes of Health (Co-Principal Investigator). 1999 to 2000

Interval Timing Behavior: Ensemble Recording and Stimulants awarded by National Institutes of Health (Principal Investigator). 1997 to 2000

Pages

Meck, W. H. Functional and neural mechanisms of interval timing. 2003, pp. 1–554.

Meck, W. H. Introduction: The persistence of time. 2003, pp. xvii–xli.

Allman, M. J., et al. “Time in the psychopathological mind.” Subjective Time: The Philosophy, Psychology, and Neuroscience of Temporality, 2014, pp. 637–54.

Matell, M. S., et al. “Integration of behavior and timing: Anatomically separate systems or distributed processing?.” Functional and Neural Mechanisms of Interval Timing, 2003, pp. 370–92.

MacDonald, C. J., and W. H. Meck. “Time flies and may also sing: Cortico-striatal mechanisms of interval timing and birdsong.” Functional and Neural Mechanisms of Interval Timing, 2003, pp. 392–418.

Dowd, Jason E., et al. “Student Learning Dispositions: Multidimensional Profiles Highlight Important Differences among Undergraduate STEM Honors Thesis Writers..” Cbe Life Sciences Education, vol. 18, no. 2, June 2019. Epmc, doi:10.1187/cbe.18-07-0141. Full Text

Bareš, Martin, et al. “Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications..” Cerebellum (London, England), vol. 18, no. 2, Apr. 2019, pp. 266–86. Epmc, doi:10.1007/s12311-018-0979-5. Full Text

Petter, Elijah A., et al. “Integrating Models of Interval Timing and Reinforcement Learning..” Trends in Cognitive Sciences, vol. 22, no. 10, Oct. 2018, pp. 911–22. Epmc, doi:10.1016/j.tics.2018.08.004. Full Text

Toda, Koji, et al. “Nigrotectal Stimulation Stops Interval Timing in Mice..” Current Biology : Cb, vol. 27, no. 24, Dec. 2017, pp. 3763-3770.e3. Epmc, doi:10.1016/j.cub.2017.11.003. Full Text

Teki, Sundeep, et al. “The Persistence of Memory: How the Brain Encodes Time in Memory..” Current Opinion in Behavioral Sciences, vol. 17, Oct. 2017, pp. 178–85. Epmc, doi:10.1016/j.cobeha.2017.09.003. Full Text

Petter, Elijah A., et al. “Interactive roles of the cerebellum and striatum in sub-second and supra-second timing: Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing..” Neuroscience and Biobehavioral Reviews, vol. 71, Dec. 2016, pp. 739–55. Epmc, doi:10.1016/j.neubiorev.2016.10.015. Full Text

Schirmer, Annett, et al. “The Socio-Temporal Brain: Connecting People in Time..” Trends in Cognitive Sciences, vol. 20, no. 10, Oct. 2016, pp. 760–72. Epmc, doi:10.1016/j.tics.2016.08.002. Full Text

Matthews, William J., and Warren H. Meck. “Temporal cognition: Connecting subjective time to perception, attention, and memory..” Psychological Bulletin, vol. 142, no. 8, Aug. 2016, pp. 865–907. Epmc, doi:10.1037/bul0000045. Full Text

Lake, Jessica I., et al. “Emotional modulation of interval timing and time perception..” Neuroscience and Biobehavioral Reviews, vol. 64, May 2016, pp. 403–20. Epmc, doi:10.1016/j.neubiorev.2016.03.003. Full Text

Pages