Warren M. Grill

Warren M. Grill

Director, Center for Neural Engineering & Neurotechnology

Professor of Biomedical Engineering

External Address: 
CIEMAS 1139, Durham, NC 27708
Internal Office Address: 
Box 90281, Dept Biomedical Engineering, Durham, NC 27708-0281
Phone: 
919.660.5276

Overview

Our research employs engineering approaches to understand and control neural function. We work on fundamental questions and applied development in electrical stimulation of the nervous system to restore function to individuals with neurological impairment or injury.

Current projects include:
• understanding the mechanisms of and developing advanced approaches to deep brain stimulation to treat movement disorders,
• developing novel approaches to peripheral nerve electrical stimulation for restoration of bladder function, 
• understanding the mechanisms of and developing advanced approaches to spinal cord stimulation to treat chronic pain,
• understanding and controlling the cellular effects of transcranial magnetic stimulation, and
• design of novel electrodes and waveforms for selective stimulation of the nervous system.

Education & Training

  • Ph.D., Case Western Reserve University 1995

  • M.S., Case Western Reserve University 1992

  • B.S., Boston University 1989

Selected Grants

Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024

Duke KURe Program awarded by National Institutes of Health (Mentor). 2013 to 2023

Duke KURe Program awarded by National Institutes of Health (Mentor). 2013 to 2023

Developing a comprehensive model for peripheral nerve stimulation of gastrointestinal function awarded by National Institutes of Health (Co Investigator). 2019 to 2023

Underactive Bladder: Mechanisms and Recovery of Sensation and Function awarded by National Institutes of Health (Mentor). 2019 to 2023

Temporal Patterns of Spinal Cord Stimulation awarded by National Institutes of Health (Principal Investigator). 2019 to 2022

Temporal Patterns of Deep Brain Stimulation awarded by National Institutes of Health (Principal Investigator). 2004 to 2022

Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials awarded by National Institutes of Health (Co Investigator). 2017 to 2022

Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022

Realistic Measurements of tDCS-Modulated Activity and Electric Fields in the Human Brain In Vivo awarded by National Institutes of Health (Collaborator). 2019 to 2021

Pages

Hokanson, J. A., et al. “Neuroprosthetic control of lower urinary tract function.” Neuroprosthetics: Theory and Practice: Second Edition, 2017, pp. 537–65. Scopus, doi:10.1142/9789813207158_0017. Full Text

Howell, B., and W. M. Grill. “Design of electrodes for stimulation and recording.” Implantable Neuroprostheses for Restoring Function, 2015, pp. 59–93. Scopus, doi:10.1016/B978-1-78242-101-6.00004-5. Full Text

Howell, Bryan, and Warren M. Grill. “Computational Models to Optimize the Electrodes and Waveforms for Deep Brain Stimulation..” Encyclopedia of Computational Neuroscience, edited by Dieter Jaeger and Ranu Jung, Springer, 2014.

McGee, Meredith, and Warren M. Grill. “Methodologies for the Restoration of Bladder and Bowel Functions..” Encyclopedia of Computational Neuroscience, edited by Dieter Jaeger and Ranu Jung, Springer, 2014.

Medina, Leonel E., and Warren M. Grill. “Mammalian Motor Nerve Fibers, Models of..” Encyclopedia of Computational Neuroscience, edited by Dieter Jaeger and Ranu Jung, Springer, 2014.

Grill, W. M. “Signal considerations for chronically implanted electrodes for brain interfacing.” Indwelling Neural Implants: Strategies for Contending with the in Vivo Environment, 2007, pp. 41–61.

Lee, D. C., et al. “Extracellular electrical stimulation of central neurons: Quantitative studies.” Handbook of Neuroprosthetic Methods, 2002, pp. 95–125.

McKee, Dana C., et al. “Randomized Controlled Trial to Assess the Impact of High Concentration Intraurethral Lidocaine on Urodynamic Voiding Parameters..” Urology, vol. 133, Nov. 2019, pp. 72–77. Pubmed, doi:10.1016/j.urology.2019.08.020. Full Text

Aberra, Aman S., et al. “Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons..” Brain Stimul, Oct. 2019. Pubmed, doi:10.1016/j.brs.2019.10.002. Full Text

Goetz, Stefan M., et al. “Accuracy of robotic coil positioning during transcranial magnetic stimulation..” J Neural Eng, vol. 16, no. 5, Sept. 2019. Pubmed, doi:10.1088/1741-2552/ab2953. Full Text

Swan, Christina Behrend, et al. “Beta Frequency Oscillations in the Subthalamic Nucleus Are Not Sufficient for the Development of Symptoms of Parkinsonian Bradykinesia/Akinesia in Rats..” Eneuro, vol. 6, no. 5, Sept. 2019. Epmc, doi:10.1523/ENEURO.0089-19.2019. Full Text

Cartmell, Samuel Cd, et al. “Multimodal characterization of the human nucleus accumbens..” Neuroimage, vol. 198, Sept. 2019, pp. 137–49. Epmc, doi:10.1016/j.neuroimage.2019.05.019. Full Text

Musselman, Eric D., et al. “Empirically Based Guidelines for Selecting Vagus Nerve Stimulation Parameters in Epilepsy and Heart Failure..” Cold Spring Harbor Perspectives in Medicine, vol. 9, no. 7, July 2019. Epmc, doi:10.1101/cshperspect.a034264. Full Text

Cassar, Isaac R., et al. “Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays..” Biomaterials, vol. 205, June 2019, pp. 120–32. Epmc, doi:10.1016/j.biomaterials.2019.03.017. Full Text

Yi, Guosheng, and Warren M. Grill. “Average firing rate rather than temporal pattern determines metabolic cost of activity in thalamocortical relay neurons..” Scientific Reports, vol. 9, no. 1, May 2019. Epmc, doi:10.1038/s41598-019-43460-8. Full Text

Grill, Warren M., and Jennifer J. DeBerry. “Innovative device illuminates the horizon of bioelectronic medicines..” Nature Reviews. Urology, vol. 16, no. 4, Apr. 2019, pp. 209–10. Epmc, doi:10.1038/s41585-019-0155-9. Full Text

Pelot, Nicole A., et al. “On the parameters used in finite element modeling of compound peripheral nerves..” Journal of Neural Engineering, vol. 16, no. 1, Feb. 2019. Epmc, doi:10.1088/1741-2552/aaeb0c. Full Text

Pages

Jovanov, I., et al. “Platform for Model-Based Design and Testing for Deep Brain Stimulation.” Proceedings  9th Acm/Ieee International Conference on Cyber Physical Systems, Iccps 2018, 2018, pp. 263–74. Scopus, doi:10.1109/ICCPS.2018.00033. Full Text

Jovanov, I., et al. “Learning-Based Control Design for Deep Brain Stimulation.” Proceedings  9th Acm/Ieee International Conference on Cyber Physical Systems, Iccps 2018, 2018, pp. 349–50. Scopus, doi:10.1109/ICCPS.2018.00048. Full Text

Lubba, C., et al. “Real-time decoding of bladder pressure from pelvic nerve activity CP.” International Ieee/Embs Conference on Neural Engineering, Ner, 2017, pp. 617–20. Scopus, doi:10.1109/NER.2017.8008427. Full Text

Behrend, C. E., et al. “Quantification of beta activity with disease progression in EEG recordings in Parkinson's disease patients.” Movement Disorders, vol. 30, WILEY-BLACKWELL, 2015, pp. S31–S31.

Pelot, N. A., et al. “Modeling the response of small myelinated and unmyelinated axons to kilohertz frequency signals.” International Ieee/Embs Conference on Neural Engineering, Ner, vol. 2015-July, 2015, pp. 406–09. Scopus, doi:10.1109/NER.2015.7146645. Full Text

Medina, L. E., and W. M. Grill. “Phantom model of transcutaneous electrical stimulation with kilohertz signals.” International Ieee/Embs Conference on Neural Engineering, Ner, vol. 2015-July, 2015, pp. 430–33. Scopus, doi:10.1109/NER.2015.7146651. Full Text

McConnell, G. C., and W. M. Grill. “Stimulation location within the substantia nigra pars reticulata differentially modulates gait in hemiparkinsonian rats.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 1210–13. Scopus, doi:10.1109/NER.2013.6696157. Full Text

McGee, M. J., and W. M. Grill. “Temporal patterns of pudendal afferent stimulation modulate reflex bladder activation.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 843–46. Scopus, doi:10.1109/NER.2013.6696066. Full Text

Howell, B., and W. M. Grill. “Model-based optimization of electrode designs for deep brain stimulation.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 154–57. Scopus, doi:10.1109/NER.2013.6695895. Full Text

Zhang, T. C., et al. “Network model of the effects of spinal cord stimulation.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 1123–26. Scopus, doi:10.1109/NER.2013.6696135. Full Text

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