Warren M. Grill
Director, Center for Neural Engineering & Neurotechnology
Professor of Biomedical Engineering
Overview
Our research employs engineering approaches to understand and control neural function. We work on fundamental questions and applied development in electrical stimulation of the nervous system to restore function to individuals with neurological impairment or injury.
Current projects include:
• understanding the mechanisms of and developing advanced approaches to deep brain stimulation to treat movement disorders,
• developing novel approaches to peripheral nerve electrical stimulation for restoration of bladder function,
• understanding the mechanisms of and developing advanced approaches to spinal cord stimulation to treat chronic pain,
• understanding and controlling the cellular effects of transcranial magnetic stimulation, and
• design of novel electrodes and waveforms for selective stimulation of the nervous system.
Selected Grants
Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024
Duke KURe Program awarded by National Institutes of Health (Mentor). 2013 to 2023
Developing a comprehensive model for peripheral nerve stimulation of gastrointestinal function awarded by National Institutes of Health (Co Investigator). 2019 to 2023
Underactive Bladder: Mechanisms and Recovery of Sensation and Function awarded by National Institutes of Health (Mentor). 2019 to 2023
Temporal Patterns of Spinal Cord Stimulation awarded by National Institutes of Health (Principal Investigator). 2019 to 2022
Temporal Patterns of Deep Brain Stimulation awarded by National Institutes of Health (Principal Investigator). 2004 to 2022
Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials awarded by National Institutes of Health (Co Investigator). 2017 to 2022
Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022
Spinal Cord Stimulation for Restoration of Bladder Function awarded by (Principal Investigator). 2020 to 2022
Realistic Measurements of tDCS-Modulated Activity and Electric Fields in the Human Brain In Vivo awarded by National Institutes of Health (Collaborator). 2019 to 2021
Pages
Hokanson, J. A., et al. “Neuroprosthetic control of lower urinary tract function.” Neuroprosthetics: Theory and Practice: Second Edition, 2017, pp. 537–65. Scopus, doi:10.1142/9789813207158_0017. Full Text
Howell, B., and W. M. Grill. “Design of electrodes for stimulation and recording.” Implantable Neuroprostheses for Restoring Function, 2015, pp. 59–93. Scopus, doi:10.1016/B978-1-78242-101-6.00004-5. Full Text
Howell, Bryan, and Warren M. Grill. “Computational Models to Optimize the Electrodes and Waveforms for Deep Brain Stimulation.” Encyclopedia of Computational Neuroscience, edited by Dieter Jaeger and Ranu Jung, Springer, 2014.
McGee, Meredith, and Warren M. Grill. “Methodologies for the Restoration of Bladder and Bowel Functions.” Encyclopedia of Computational Neuroscience, edited by Dieter Jaeger and Ranu Jung, Springer, 2014.
Medina, Leonel E., and Warren M. Grill. “Mammalian Motor Nerve Fibers, Models of.” Encyclopedia of Computational Neuroscience, edited by Dieter Jaeger and Ranu Jung, Springer, 2014.
Grill, W. M. “Signal considerations for chronically implanted electrodes for brain interfacing.” Indwelling Neural Implants: Strategies for Contending with the in Vivo Environment, 2007, pp. 41–61.
Lee, D. C., et al. “Extracellular electrical stimulation of central neurons: Quantitative studies.” Handbook of Neuroprosthetic Methods, 2002, pp. 95–125.
Schmidt, Stephen L., et al. “Continuous deep brain stimulation of the subthalamic nucleus may not modulate beta bursts in patients with Parkinson's disease.” Brain Stimul, vol. 13, no. 2, Mar. 2020, pp. 433–43. Pubmed, doi:10.1016/j.brs.2019.12.008. Full Text
Swan, Brandon D., et al. “Effects of ramped-frequency thalamic deep brain stimulation on tremor and activity of modeled neurons.” Clin Neurophysiol, vol. 131, no. 3, Mar. 2020, pp. 625–34. Pubmed, doi:10.1016/j.clinph.2019.11.060. Full Text
Aberra, Aman S., et al. “Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons.” Brain Stimul, vol. 13, no. 1, Jan. 2020, pp. 175–89. Pubmed, doi:10.1016/j.brs.2019.10.002. Full Text
McKee, Dana C., et al. “Randomized Controlled Trial to Assess the Impact of High Concentration Intraurethral Lidocaine on Urodynamic Voiding Parameters.” Urology, vol. 133, Nov. 2019, pp. 72–77. Pubmed, doi:10.1016/j.urology.2019.08.020. Full Text
Goetz, Stefan M., et al. “Accuracy of robotic coil positioning during transcranial magnetic stimulation.” J Neural Eng, vol. 16, no. 5, Sept. 2019, p. 054003. Pubmed, doi:10.1088/1741-2552/ab2953. Full Text
Cartmell, Samuel Cd, et al. “Multimodal characterization of the human nucleus accumbens.” Neuroimage, vol. 198, Sept. 2019, pp. 137–49. Epmc, doi:10.1016/j.neuroimage.2019.05.019. Full Text
Swan, Christina Behrend, et al. “Beta Frequency Oscillations in the Subthalamic Nucleus Are Not Sufficient for the Development of Symptoms of Parkinsonian Bradykinesia/Akinesia in Rats.” Eneuro, vol. 6, no. 5, Sept. 2019. Epmc, doi:10.1523/ENEURO.0089-19.2019. Full Text
Musselman, Eric D., et al. “Empirically Based Guidelines for Selecting Vagus Nerve Stimulation Parameters in Epilepsy and Heart Failure.” Cold Spring Harbor Perspectives in Medicine, vol. 9, no. 7, July 2019. Epmc, doi:10.1101/cshperspect.a034264. Full Text
Cassar, Isaac R., et al. “Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays.” Biomaterials, vol. 205, June 2019, pp. 120–32. Epmc, doi:10.1016/j.biomaterials.2019.03.017. Full Text
Yi, Guosheng, and Warren M. Grill. “Average firing rate rather than temporal pattern determines metabolic cost of activity in thalamocortical relay neurons.” Scientific Reports, vol. 9, no. 1, May 2019, p. 6940. Epmc, doi:10.1038/s41598-019-43460-8. Full Text
Pages
Jovanov, I., et al. “Learning-Based Control Design for Deep Brain Stimulation.” Proceedings 9th Acm/Ieee International Conference on Cyber Physical Systems, Iccps 2018, 2018, pp. 349–50. Scopus, doi:10.1109/ICCPS.2018.00048. Full Text
Jovanov, I., et al. “Platform for Model-Based Design and Testing for Deep Brain Stimulation.” Proceedings 9th Acm/Ieee International Conference on Cyber Physical Systems, Iccps 2018, 2018, pp. 263–74. Scopus, doi:10.1109/ICCPS.2018.00033. Full Text
Lubba, C., et al. “Real-time decoding of bladder pressure from pelvic nerve activity CP.” International Ieee/Embs Conference on Neural Engineering, Ner, 2017, pp. 617–20. Scopus, doi:10.1109/NER.2017.8008427. Full Text
Behrend, C. E., et al. “Quantification of beta activity with disease progression in EEG recordings in Parkinson's disease patients.” Movement Disorders, vol. 30, WILEY-BLACKWELL, 2015, pp. S31–S31.
Pelot, N. A., et al. “Modeling the response of small myelinated and unmyelinated axons to kilohertz frequency signals.” International Ieee/Embs Conference on Neural Engineering, Ner, vol. 2015-July, 2015, pp. 406–09. Scopus, doi:10.1109/NER.2015.7146645. Full Text
Medina, L. E., and W. M. Grill. “Phantom model of transcutaneous electrical stimulation with kilohertz signals.” International Ieee/Embs Conference on Neural Engineering, Ner, vol. 2015-July, 2015, pp. 430–33. Scopus, doi:10.1109/NER.2015.7146651. Full Text
McConnell, G. C., and W. M. Grill. “Stimulation location within the substantia nigra pars reticulata differentially modulates gait in hemiparkinsonian rats.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 1210–13. Scopus, doi:10.1109/NER.2013.6696157. Full Text
McGee, M. J., and W. M. Grill. “Temporal patterns of pudendal afferent stimulation modulate reflex bladder activation.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 843–46. Scopus, doi:10.1109/NER.2013.6696066. Full Text
Howell, B., and W. M. Grill. “Model-based optimization of electrode designs for deep brain stimulation.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 154–57. Scopus, doi:10.1109/NER.2013.6695895. Full Text
Zhang, T. C., et al. “Network model of the effects of spinal cord stimulation.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 1123–26. Scopus, doi:10.1109/NER.2013.6696135. Full Text