William Christopher Wetsel

William Christopher Wetsel

Associate Professor in Psychiatry and Behavioral Sciences

External Address: 
354 Sands Bldg, Durham, NC 27710
Internal Office Address: 
Box 103203 Med Ctr, Durham, NC 27710
Phone: 
919.684.4574

Overview

RESEARCH INTERESTS
Last Updated: 31 December 1997

My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the expression of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, an identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology. The advent of gene manipulation in mice has permitted specific genes to be targeted for disruption, mutation, and/or overexpression in the whole organism or in selected regions or cells in the nervous and other systems. In this way, primary and secondary effects of a given gene manipulation can be related to various neuroendoctine, neurological, or psychiatric conditions in humans. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have neurobehaviorally phenotyped many different lines of inbred and mutant mice for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. Following the development of mouse models, we have worked with various investigators to identify the molecular and cellular basis of the neuroendocrine and/or behavioral abnormalities. We are working also with medicinal chemists and certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in the mutant mice. Some of these preclinical studies are now forming a basis for clinical trials in humans.

Education & Training

  • Ph.D., Massachusetts Institute of Technology 1983

Selected Grants

In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice awarded by National Institutes of Health (Associate Research Professor). 2016 to 2021

MECHANISTIC INSIGHTS INTO LSD ACTIONS AT 5-HT2A-SEROTONIN RECEPTORS awarded by University of North Carolina - Chapel Hill (Principal Investigator). 2018 to 2021

Akt/GSK-3 Signaling Cascade and the Actions of Dopamine awarded by National Institutes of Health (Co Investigator). 2005 to 2020

Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse models awarded by Yale University (Principal Investigator). 2019 to 2020

Novel Adjuvants and Carriers for Opiod Vaccines awarded by National Institutes of Health (Co Investigator). 2014 to 2020

Behavior and Physiology in Aging awarded by National Institutes of Health (Mentor). 2015 to 2020

Developing a New Therapeutic Agent for Kabuki Syndrome awarded by Rescindo Therapeutics Inc (Principal Investigator). 2019 to 2020

Simultaneous and Bidirectional Chemogenetic Control of Mesolimbic and Nigrostriatal Circuits awarded by National Institutes of Health (Co Investigator). 2018 to 2020

Molecular, Synaptic, and Circuit Basis for Schizophrenia-related Phenotypes awarded by National Institutes of Health (Co Investigator). 2014 to 2020

Developing a new therapeutic agent for Kabuki syndrome awarded by Rescindo Therapeutics Inc (Co Investigator). 2018 to 2019

Pages

McGaughey, Kara D., et al. “Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice.Sci Rep, vol. 9, no. 1, Mar. 2019, p. 3281. Pubmed, doi:10.1038/s41598-019-40140-5. Full Text

Huffman, William J., et al. “Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice.Brain Stimul, vol. 12, no. 1, Jan. 2019, pp. 19–29. Pubmed, doi:10.1016/j.brs.2018.10.005. Full Text

Velagapudi, Ravikanth, et al. “Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model.Front Immunol, vol. 10, 2019, p. 2675. Pubmed, doi:10.3389/fimmu.2019.02675. Full Text

McGaughey, Kara D., et al. “Correction: Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing.Plos One, vol. 14, no. 2, 2019, p. e0212712. Pubmed, doi:10.1371/journal.pone.0212712. Full Text

Helseth, Ashley R., et al. “Novel E815K knock-in mouse model of alternating hemiplegia of childhood.Neurobiol Dis, vol. 119, Nov. 2018, pp. 100–12. Pubmed, doi:10.1016/j.nbd.2018.07.028. Full Text

Bey, Alexandra L., et al. “Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.Transl Psychiatry, vol. 8, no. 1, Apr. 2018, p. 94. Pubmed, doi:10.1038/s41398-018-0142-6. Full Text

Wang, Xiaoting, et al. “Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference.Neuropsychopharmacology, vol. 43, no. 5, Apr. 2018, pp. 953–63. Pubmed, doi:10.1038/npp.2017.178. Full Text

Martyn, Amanda C., et al. “GIT1 regulates synaptic structural plasticity underlying learning.Plos One, vol. 13, no. 3, 2018, p. e0194350. Pubmed, doi:10.1371/journal.pone.0194350. Full Text

McGaughey, Kara D., et al. “Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing.Plos One, vol. 13, no. 8, 2018, p. e0202858. Pubmed, doi:10.1371/journal.pone.0202858. Full Text

Butler, Ryan K., et al. “Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia.Neurosci Lett, vol. 661, Nov. 2017, pp. 11–17. Pubmed, doi:10.1016/j.neulet.2017.09.025. Full Text

Pages