William Christopher Wetsel

William Christopher Wetsel

Associate Professor in Psychiatry and Behavioral Sciences

External Address: 
354 Sands Bldg, Durham, NC 27710
Internal Office Address: 
Box 103203 Med Ctr, Durham, NC 27710
Phone: 
919.684.4574

Overview

RESEARCH INTERESTS
Last Updated: 27 October 2020

My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the presentation of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, the identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology.  The use of genetic technologies has allowed specific genes in selected cells and in neural pathways to be related to certain molecular, biochemical, cellular, physiological, and behavioral dysfunctions. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have phenotyped many different lines of inbred and mutant mice for my own work as well as for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. We are working also with academic medicinal chemists and/or certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in various mutant mouse models. Some of these preclinical studies have formed a basis for clinical trials in humans.

Education & Training

  • Ph.D., Massachusetts Institute of Technology 1983

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Daigle, Tanya L., et al. “Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.Eur J Neurosci, vol. 34, no. 9, Nov. 2011, pp. 1378–89. Pubmed, doi:10.1111/j.1460-9568.2011.07874.x. Full Text

Cohen, Sonia, et al. “Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function.Neuron, vol. 72, no. 1, Oct. 2011, pp. 72–85. Pubmed, doi:10.1016/j.neuron.2011.08.022. Full Text

Bhatia, Kamal S., et al. “Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine.Behavioural Brain Research, vol. 223, no. 1, Sept. 2011, pp. 227–32. Epmc, doi:10.1016/j.bbr.2011.04.045. Full Text

Wang, Xiaoming, et al. “Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.Hum Mol Genet, vol. 20, no. 15, Aug. 2011, pp. 3093–108. Pubmed, doi:10.1093/hmg/ddr212. Full Text

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