William Christopher Wetsel

William Christopher Wetsel

Associate Professor in Psychiatry and Behavioral Sciences

External Address: 
354 Sands Bldg, Durham, NC 27710
Internal Office Address: 
Box 103203 Med Ctr, Durham, NC 27710
Phone: 
919.684.4574

Overview

RESEARCH INTERESTS
Last Updated: 27 October 2020

My laboratory uses genetically-modified mice to study the roles that certain genes and gene products play in the presentation of abnormal neuroendocrine, neurological, and psychiatric responses. Traditionally, the identification of neuroendocrine dysfunction has involved biochemical analyses of hormonal responses, those for neurological disorders have relied upon behavioral and postmortem analyses, and those for psychiatric conditions have depended upon phenomenology.  The use of genetic technologies has allowed specific genes in selected cells and in neural pathways to be related to certain molecular, biochemical, cellular, physiological, and behavioral dysfunctions. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University (http://sites.duke.edu/mousebehavioralcore/), we have phenotyped many different lines of inbred and mutant mice for my own work as well as for investigators at Duke and at other research institutions. As a consequence, we have helped to develop many different mouse genetic models of neuroendocrine and neuropsychiatric illness. We are working also with academic medicinal chemists and/or certain pharmacological/biotechnological companies to identify novel compounds that will ameliorate abnormal responses in various mutant mouse models. Some of these preclinical studies have formed a basis for clinical trials in humans.

Education & Training

  • Ph.D., Massachusetts Institute of Technology 1983

Selected Grants

Stress and Behavior in Health and Disease awarded by National Institutes of Health (Mentor). 1989 to 2011

Pharmacometabolomics Research Network awarded by National Institutes of Health (Co Investigator). 2010 to 2011

Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior awarded by National Institutes of Health (Co Investigator). 2007 to 2010

Cocaine Withdrawal: A Window of Treatment Opportunity awarded by National Institutes of Health (Co Investigator). 1999 to 2010

Collaborative & Physiological Experiments to Breed CPE KO Mice awarded by National Institutes of Health (Principal Investigator). 2006 to 2007

The Pathophysiology of CMT2A in Cell and Animal Models awarded by National Institutes of Health (Co Investigator). 2006 to 2007

Collaborative & Physiological Experiments to Breed CPE KO Mice awarded by National Institutes of Health (Principal Investigator). 2005

Collaborative & Physiological Experiments awarded by National Institutes of Health (Principal Investigator). 2004 to 2005

Genetic Rescue Of Pro-Lhrh Processing In Cpefat Mice awarded by National Institutes of Health (Principal Investigator). 1998 to 2004

Collaborative & Physiological Experiments of CPE K/O Mice awarded by National Institutes of Health (Principal Investigator). 2002 to 2003

Pages

Weitzel, Douglas H., et al. “Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.Mol Cancer Ther, vol. 14, no. 1, Jan. 2015, pp. 70–79. Pubmed, doi:10.1158/1535-7163.MCT-14-0343. Full Text

Hunanyan, Arsen S., et al. “Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization.Epilepsia, vol. 56, no. 1, Jan. 2015, pp. 82–93. Pubmed, doi:10.1111/epi.12878. Full Text

Wang, Liangli, et al. “Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.Journal of Psychiatry & Neuroscience : Jpn, vol. 39, no. 4, July 2014, pp. 259–66. Epmc, doi:10.1503/jpn.130148. Full Text

Gaier, E. D., et al. “In vivo and in vitro analyses of amygdalar function reveal a role for copper.J Neurophysiol, vol. 111, no. 10, May 2014, pp. 1927–39. Pubmed, doi:10.1152/jn.00631.2013. Full Text

Deng, Jie V., et al. “MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 34, no. 13, Mar. 2014, pp. 4519–27. Epmc, doi:10.1523/jneurosci.2821-13.2014. Full Text

Sassano, M. F., et al. D2 Functionally Selective Ligands: Novel Therapeutics? Dec. 2013, p. 105. Scopus, doi:10.1016/B978-0-12-800044-1.00091-X. Full Text

Gaier, Eric D., et al. “Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity.J Neurochem, vol. 127, no. 5, Dec. 2013, pp. 605–19. Pubmed, doi:10.1111/jnc.12438. Full Text

Wetsel, William C., et al. “Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.Proc Natl Acad Sci U S A, vol. 110, no. 43, Oct. 2013, pp. 17362–67. Pubmed, doi:10.1073/pnas.1314698110. Full Text

Gomes, Ivone, et al. “GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.Proc Natl Acad Sci U S A, vol. 110, no. 40, Oct. 2013, pp. 16211–16. Pubmed, doi:10.1073/pnas.1312938110. Full Text

Sachs, Benjamin D., et al. “The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.The International Journal of Neuropsychopharmacology, vol. 16, no. 9, Oct. 2013, pp. 2081–94. Epmc, doi:10.1017/s1461145713000321. Full Text

Pages