Wolfgang Bernhard Liedtke
Adjunct Professor in the Department of Neurology
Overview
Research Interests in the Liedtke-Lab:
- Pain/ nociception
- Sensory transduction and -transmission
- TRP ion channels
- Water and salt equilibrium regulated by the central nervous system
Visit the lab's website, download papers and read Dr. Liedtke's CV here.
Selected Grants
Integrated Training in Anesthesiology Research awarded by National Institutes of Health (Mentor). 1996 to 2026
Neurobiology Training Program awarded by National Institutes of Health (Mentor). 2019 to 2024
Duke Pain Early-phase Research Clinical Center (PERC) awarded by National Institutes of Health (Collaborator). 2019 to 2024
COVID-19 Fast Grant awarded by George Mason University (Principal Investigator). 2020 to 2021
Deconstructing Cartilage Mechanotransduction by Piezo Channels awarded by National Institutes of Health (Principal Investigator). 2020 to 2021
Novel pathways regulating calcium mediated contractility and inflammation in the pregnant uterus awarded by Stanford University (Principal Investigator). 2018 to 2021
Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020
Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020
Not SciFi: How to Get Rid of Trigeminal Neuralgia awarded by The Facial Pain Research Foundation (Principal Investigator). 2018 to 2020
Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences (Mentor). 2013 to 2019
Pages
Simon, S. A., and R. Gutierrez. “TRP channels at the periphery of the taste and trigeminal systems.” Neurobiology of TRP Channels, 2017, pp. 113–24. Scopus, doi:10.4324/9781315152837. Full Text
Liedtke, W. “TRP channels and osmoregulation: TRPV4-mediated signaling.” TRP Channels in Health and Disease: Implications for Diagnosis and Therapy, 2011, pp. 153–70.
Chen, Yong, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology, Apr. 2021. Pubmed, doi:10.1053/j.gastro.2021.03.049. Full Text
Lee, Whasil, et al. “Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.” Proc Natl Acad Sci U S A, vol. 118, no. 13, Mar. 2021. Pubmed, doi:10.1073/pnas.2001611118. Full Text Open Access Copy
Kanugula, A. K., et al. “Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity.” Angiogenesis, Jan. 2021. Scopus, doi:10.1007/s10456-021-09775-9. Full Text
Nims, Robert J., et al. “A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues.” Sci Adv, vol. 7, no. 5, Jan. 2021. Pubmed, doi:10.1126/sciadv.abd9858. Full Text
Rosenkranz, S. C., et al. “TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation.” Frontiers in Cell and Developmental Biology, vol. 8, Aug. 2020. Scopus, doi:10.3389/fcell.2020.00849. Full Text
Kuebler, Wolfgang M., et al. “Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach.” Am J Physiol Lung Cell Mol Physiol, vol. 318, no. 6, June 2020, pp. L1239–43. Pubmed, doi:10.1152/ajplung.00161.2020. Full Text
Swain, Sandip M., et al. “TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.” J Clin Invest, vol. 130, no. 5, May 2020, pp. 2527–41. Pubmed, doi:10.1172/JCI134111. Full Text
Ottolini, Matteo, et al. “Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.” Circulation, vol. 141, no. 16, Apr. 2020, pp. 1318–33. Pubmed, doi:10.1161/CIRCULATIONAHA.119.043385. Full Text
Xu, Biao, et al. “The multifunctional peptide DN-9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ- and κ-opioid receptors.” Br J Pharmacol, vol. 177, no. 1, Jan. 2020, pp. 93–109. Pubmed, doi:10.1111/bph.14848. Full Text
Gilchrist, Christopher L., et al. “TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension.” Proc Natl Acad Sci U S A, vol. 116, no. 6, Feb. 2019, pp. 1992–97. Pubmed, doi:10.1073/pnas.1811095116. Full Text
Pages
Seth, Ratanesh K., et al. “TRPV4 prevents tissue injury in diseased fatty liver by blocking CYP2E1-mediated redox-toxicity via Kupffer cell-induced nitric oxide production.” Hepatology, vol. 64, WILEY, 2016, pp. 793A-794A.
Seth, Ratanesh Kumar, et al. “TRPV4 Modulates CYP2E1 Function in Nonalcoholic Steatohepatitis Progression.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.
Seth, Ratanesh K., et al. “TRPV4 regulates inflammation and Kupffer cell activation in nonalcoholic steatohepatitis by attenuation of CYP2E1-mediated oxidative stress.” Hepatology, vol. 62, WILEY-BLACKWELL, 2015, pp. 1248A-1248A.
Das, Suvarthi, et al. “TRPV4 deficiency enhances TLR4 recruitment to lipid rafts exhibiting exacerbated stellate cell activation and fibrosis in experimental nonalcoholic steatohepatitis.” Hepatology, vol. 62, WILEY-BLACKWELL, 2015, pp. 682A-682A.
Bauer, W., et al. “Topical Anti-Inflammatory Therapy in the Treatment of Acute Migraine; Role of Trigeminal Nerve Peripheral Fibers.” Headache, vol. 55, WILEY-BLACKWELL, 2015, pp. 140–140.
Klein, R. C., et al. “Static magnetic field modulates excitatory activity in layer II/III pyramidal neurons of the rat motor cortex.” International Ieee/Embs Conference on Neural Engineering, Ner, 2013, pp. 1190–93. Scopus, doi:10.1109/NER.2013.6696152. Full Text
Sham, James S. K., et al. “UPREGULATION OF TRPV4 CHANNELS IN PULMONARY ARTERIES CONTRIBUTES TO CHRONIC HYPOXIA INDUCED MYOGENIC TONE AND PULMONARY HYPERTENSION.” Journal of Physiological Sciences, vol. 59, SPRINGER TOKYO, 2009, pp. 264–264.
Liedtke, W., et al. “Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans.” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 24, 2003, pp. 14531–36. Scopus, doi:10.1073/pnas.2235619100. Full Text
Kuebler, Wolfgang, et al. COVID-19: Urgent Reconsideration of Lung Edema as a Preventable Outcome: Inhibition of TRPV4 As a Promising and Feasible Approach. 23 Mar. 2020. Pubmed, doi:10.2139/ssrn.3558887. Full Text