Wolfgang Bernhard Liedtke

Wolfgang Bernhard Liedtke

Professor of Neurology

External Address: 
201G Bryan Res Bldg, Durham, NC 27710
Internal Office Address: 
Duke Box 2900, Durham, NC 27710


Research Interests in the Liedtke-Lab:

  • Pain/ nociception
  • Sensory transduction and -transmission
  • TRP ion channels
  • Water and salt equilibrium regulated by the central nervous system

Visit the lab's website, download papers and read Dr. Liedtke's CV here.

Education & Training

  • Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994

  • Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993

  • Resident, Neurology, University of Tubingen (Germany) 1989 - 1991

  • Ph.D., Ruhr-Universitat Bochum (Germany) 1990

  • Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris (France) 1988 - 1989

  • M.D., University of Cologne, Faculty of Medicine (Germany) 1989

  • Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich (Switzerland) 1988 - 1988

Selected Grants

Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences (Mentor). 2013 to 2019

Biomedical Researcher Development Scholarship (BRDS) Research Career Development Award (K12) awarded by University of North Carolina - Chapel Hill (Mentor). 2015 to 2018

Basic predoctoral training in neuroscience awarded by National Institutes of Health (Training Faculty). 1992 to 2018

Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health (Minor User). 2016 to 2018

Molecular Mechanisms of Regulation of Sodium-Appetite in Mammals awarded by Texas Biomedical Research Institute (Principal Investigator). 2016 to 2017

Small molecule targeting of dual TRP channels to attenuate inflammation and fibrosis awarded by North Carolina Biotechnology Center (Principal Investigator). 2016 to 2017

Engineering cartilage mechanotransduction for treatment of chondrocyte injury awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

Transdermal pain therapy with ELSM11 (formulated ketoprofen) in a spectrum of pre-clinical pain models awarded by Achelios Therapeutics (Principal Investigator). 2014 to 2016

Masticatory sensitization of trigeminal ganglion sensory neurons awarded by National Institutes of Health (Principal Investigator). 2014 to 2016

Control of trigeminal touch sensory circuit assembly awarded by National Institutes of Health (Collaborating Investigator). 2009 to 2016


Moore, Carlene, et al. “Regulation of Pain and Itch by TRP Channels.Neurosci Bull, vol. 34, no. 1, Feb. 2018, pp. 120–42. Pubmed, doi:10.1007/s12264-017-0200-8. Full Text

Rodriguez, Erica, et al. “A craniofacial-specific monosynaptic circuit enables heightened affective pain.Nat Neurosci, vol. 20, no. 12, Dec. 2017, pp. 1734–43. Pubmed, doi:10.1038/s41593-017-0012-1. Full Text Open Access Copy

Arredondo Zamarripa, David, et al. “Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference.Sci Rep, vol. 7, no. 1, Oct. 2017, p. 13094. Pubmed, doi:10.1038/s41598-017-13621-8. Full Text

Benemei, Silvia, et al. “The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.Br J Pharmacol, vol. 174, no. 17, Sept. 2017, pp. 2897–911. Pubmed, doi:10.1111/bph.13917. Full Text

Chen, Yong, et al. “TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.J Invest Dermatol, vol. 137, no. 4, Apr. 2017, pp. 801–04. Pubmed, doi:10.1016/j.jid.2016.12.013. Full Text

Liedtke, Wolfgang B. “Deconstructing mammalian thermoregulation.Proc Natl Acad Sci U S A, vol. 114, no. 8, Feb. 2017, pp. 1765–67. Pubmed, doi:10.1073/pnas.1620579114. Full Text

Michalick, Laura, et al. “Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo.Anesthesiology, vol. 126, no. 2, Feb. 2017, pp. 300–11. Pubmed, doi:10.1097/ALN.0000000000001443. Full Text

Lee, W., et al. “Role of Piezo Channels in Joint Health and Injury.Curr Top Membr, vol. 79, 2017, pp. 263–73. Pubmed, doi:10.1016/bs.ctm.2016.10.003. Full Text

Seth, Ratanesh K., et al. “TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.Free Radic Biol Med, vol. 102, Jan. 2017, pp. 260–73. Pubmed, doi:10.1016/j.freeradbiomed.2016.11.047. Full Text

Solís-López, A., et al. “Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells.Plos One, vol. 12, no. 2, 2017, p. e0171366. Pubmed, doi:10.1371/journal.pone.0171366. Full Text