Wolfgang Bernhard Liedtke

Wolfgang Bernhard Liedtke

Professor of Neurology

External Address: 
201G Bryan Res Bldg, Durham, NC 27710
Internal Office Address: 
Duke Box 2900, Durham, NC 27710


Research Interests in the Liedtke-Lab:

  • Pain/ nociception
  • Sensory transduction and -transmission
  • TRP ion channels
  • Water and salt equilibrium regulated by the central nervous system

Visit the lab's website, download papers and read Dr. Liedtke's CV here.

Education & Training

  • Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994

  • Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993

  • Resident, Neurology, University of Tubingen (Germany) 1989 - 1991

  • Ph.D., Ruhr-Universitat Bochum (Germany) 1990

  • Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris (France) 1988 - 1989

  • M.D., University of Cologne, Faculty of Medicine (Germany) 1989

  • Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich (Switzerland) 1988 - 1988

Selected Grants

Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health (Training Faculty). 2005 to 2016

Commitment of Funds for NCBC Grant (3834531) awarded by Achelios Therapeutics (Principal Investigator). 2012 to 2015

Small Molecule Therapy to Inhibit Osteoarthritis Progression in the Aging awarded by Cytex Therapeutics Inc. (Principal Investigator). 2013 to 2015

TRP and AQP Channels: Modulation of Function, Raft Location by Membrane Lipids awarded by National Institutes of Health (Co Investigator). 1980 to 2015

Mechanical and Osmotic Signaling in Chondrocytes awarded by National Institutes of Health (Co Investigator). 2001 to 2015

Molecular Mechanisms of Regulation of Sodium-Appetite in Mammals awarded by G. Harold & Leila Y. Mathers Foundation (Principal Investigator). 2014 to 2015

Live-Animal Micro-CT System awarded by National Institutes of Health (Major User). 2012 to 2014

Role of trpv4 in trigeminally mediated nociception awarded by National Institutes of Health (Principal Investigator). 2007 to 2012

Sex-specific gene regulation of neuronal chloride co-transporter, kcc2 awarded by National Institutes of Health (Principal Investigator). 2009 to 2012

COPAS BIOSORT Worm Sorter awarded by National Institutes of Health (Principal Investigator). 2009 to 2010


Watanabe, Kentaro, et al. “Isolated Deep Ear Canal Pain: Possible Role of Auricular Branch of Vagus Nerve-Case Illustrations with Cadaveric Correlation.World Neurosurg, vol. 96, Dec. 2016, pp. 293–301. Pubmed, doi:10.1016/j.wneu.2016.08.102. Full Text

Kanju, Patrick, and Wolfgang Liedtke. “Pleiotropic function of TRPV4 ion channels in the central nervous system.Exp Physiol, vol. 101, no. 12, Dec. 2016, pp. 1472–76. Pubmed, doi:10.1113/EP085790. Full Text

O’Conor, Christopher J., et al. “Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.Sci Rep, vol. 6, July 2016, p. 29053. Pubmed, doi:10.1038/srep29053. Full Text

Kanju, Patrick, et al. “Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.Sci Rep, vol. 6, June 2016, p. 26894. Pubmed, doi:10.1038/srep26894. Full Text Open Access Copy

Chen, Yong, et al. “Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.J Biol Chem, vol. 291, no. 19, May 2016, pp. 10252–62. Pubmed, doi:10.1074/jbc.M116.716464. Full Text Open Access Copy

Yin, Jun, et al. “Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury.Am J Respir Cell Mol Biol, vol. 54, no. 3, Mar. 2016, pp. 370–83. Pubmed, doi:10.1165/rcmb.2014-0225OC. Full Text

Lee, W., et al. “Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression.” Biophysical Journal, vol. 110, no. 3, Feb. 2016, pp. 349a-349a.

Fichna, J., et al. “Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission.J Mol Med (Berl), vol. 93, no. 12, Dec. 2015, pp. 1297–309. Pubmed, doi:10.1007/s00109-015-1336-5. Full Text

Zaelzer, Cristian, et al. “ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress.Cell Rep, vol. 13, no. 1, Oct. 2015, pp. 23–30. Pubmed, doi:10.1016/j.celrep.2015.08.061. Full Text

Cenac, Nicolas, et al. “Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.Gastroenterology, vol. 149, no. 2, Aug. 2015, pp. 433-44.e7. Pubmed, doi:10.1053/j.gastro.2015.04.011. Full Text