Wolfgang Bernhard Liedtke

Wolfgang Bernhard Liedtke

Professor of Neurology

External Address: 
201G Bryan Res Bldg, Durham, NC 27710
Internal Office Address: 
Duke Box 2900, Durham, NC 27710


Research Interests in the Liedtke-Lab:

  • Pain/ nociception
  • Sensory transduction and -transmission
  • TRP ion channels
  • Water and salt equilibrium regulated by the central nervous system

Visit the lab's website, download papers and read Dr. Liedtke's CV here.

Education & Training

  • Resident, Psychiatry, University of Duisburg Essen (Germany) 1993 - 1994

  • Resident, Neurology, University of Duisburg Essen (Germany) 1991 - 1993

  • Resident, Neurology, University of Tubingen (Germany) 1989 - 1991

  • Ph.D., Ruhr-Universitat Bochum (Germany) 1990

  • Medicine/Surgery/Neurology Intenship, Surgery, Hôtel-Dieu de Paris (France) 1988 - 1989

  • M.D., University of Cologne, Faculty of Medicine (Germany) 1989

  • Medicine/Surgery/Neurology Intenship, Neurology, University Hospital Zurich (Switzerland) 1988 - 1988

Selected Grants

Molecular studies of osmotic neural sensing awarded by National Institute of Mental Health (Principal Investigator). 2002 to 2006


Goldenberg, Neil M., et al. “TRPV4 Is Required for Hypoxic Pulmonary Vasoconstriction.Anesthesiology, vol. 122, no. 6, June 2015, pp. 1338–48. Pubmed, doi:10.1097/ALN.0000000000000647. Full Text

Lin, M. T., et al. “Functional coupling of TRPV4, IK, and SK channels contributes to Ca2+-dependent endothelial injury in rodent lung.” Pulmonary Circulation, vol. 5, no. 2, June 2015, pp. 279–90. Scopus, doi:10.1086/680166. Full Text

Zhao, Peishen, et al. “Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.J Biol Chem, vol. 290, no. 22, May 2015, pp. 13875–87. Pubmed, doi:10.1074/jbc.M115.642736. Full Text

Zelenski, Nicole A., et al. “Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage.Arthritis Rheumatol, vol. 67, no. 5, May 2015, pp. 1286–94. Pubmed, doi:10.1002/art.39034. Full Text

McNulty, Amy L., et al. “TRPV4 as a therapeutic target for joint diseases.Naunyn Schmiedebergs Arch Pharmacol, vol. 388, no. 4, Apr. 2015, pp. 437–50. Pubmed, doi:10.1007/s00210-014-1078-x. Full Text

Chen, L., et al. “Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature.Acta Physiol (Oxf), vol. 213, no. 2, Feb. 2015, pp. 481–91. Pubmed, doi:10.1111/apha.12355. Full Text

Liedtke, Wolfgang. “A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells.Neuron, vol. 84, no. 5, Dec. 2014, pp. 889–91. Pubmed, doi:10.1016/j.neuron.2014.11.015. Full Text

Chen, Yong, et al. “TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.Pain, vol. 155, no. 12, Dec. 2014, pp. 2662–72. Pubmed, doi:10.1016/j.pain.2014.09.033. Full Text Open Access Copy

Lee, Whasil, et al. “Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage.Proc Natl Acad Sci U S A, vol. 111, no. 47, Nov. 2014, pp. E5114–22. Pubmed, doi:10.1073/pnas.1414298111. Full Text Open Access Copy